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anti-ALB antibody :: Goat albumin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS573594 anti-ALB antibody
Unit / Price
1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

albumin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti Human albumin, conjugated with Biotin

 Product Gene Name   

anti-ALB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (74269972..74287129). Location: 4q13.3
 OMIM    103600
 3D Structure    ModBase 3D Structure for P02768
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Inter-species cross-reactivity is a normal feature of antibodies to mammalian serum proteins, since homologous proteins of different species frequently share antigenic determinants. The degree of crossreactivity is also dependent on the concentrations of
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 Specificity    The defined antibody specificity is directed to albumin as tested against human sera. In immunoelectrophoresis and double radial immunodiffusion (Ouchterlony), using various antiserum concentrations against appropriate concentrations of the immunogen, a single characteristic precipitin line is obtained which shows a reaction of identity with the precipitin lines obtained against human serum and the purified albumin.
 Purity/Purification    Hyperimmune antisera with strong precipitating activity are selected for fractionation by salt-precipitation and purification of the IgG (7S) fraction by DEAE-chromatography.
 Form/Format    Purified hyperimmune goat IgG lyophilized from a solution in phosphate buffered saline (PBS, pH 7.2).
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 Conjugation    Biotin
 Immunogen    Albumin is a stable small polypeptide with a strong antigenicity. Its molecular weight is about 69,000. It has a high mobility in electrophoresis, shows macro-heterogeneity especially under pathological conditions and it can bind a large number of physiological and non-physiologica! molecules. Albumin is isolated from human serum by sequential precipitation and purified by ion exchange chromatography and affinity chromatography. Freund's complete adjuvant is used in the first step of the immunization procedure.
 Adsorption    Immunoaffinity adsorbed using insolubilized antigens as required, to eliminate antibodies reacting with other serum proteins. The use of insolubilized adsorption antigens prevents the presence of excess adsorbent protein or immune complexes in the antiserum.
 Physicochemical characteristics    IgG protein concentration 7.5 mg/ml. Biotin/lgG protein molar ratio (B/P) approximately 5.7. No foreign proteins added.
 Marker    N-Hydroxysuccinimidobiotin
 Handling    The lyophilized immunoconjugate is shipped at ambient temperature and may be stored at +4 degree C; prolonged storage at or below -20 degree C. It is reconstituted by adding 1 ml sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20 degree C. Prior to use, an aliquot is thawed slowly at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at +4 degree C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the product.
 Caution    This immunoconjugate should be handled by qualified persons only and appropriate precautions should be taken in its handling and disposal, and of all associated materials. For in vitro laboratory research purposes only.
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 Preparation and Storage    Lyophilized at +4 Degree C = at least 10 years
reconstituted at or below -20 Degree C = 3-5 years
reconstituted at +4 Degree C = 7 days
 Other Notes    Small volumes of anti-ALB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ALB antibody

   In immunocytochemical and immunohistochemical use for the detection of albumin at the cellular and subcellular level by staining of appropriately treated cell and tissue substrates; in non-isotopic assay methodology (e.g. ELISA) to measure albumin in human serum or other body fluids. As a second step an avidin or streptavidin conjugate of the user's choice has to be used.

This immunoconjugate is not pre-diluted. The optimum working dilution of each conjugate should be established by titration before being used. Excess labelled antibody must be avoided because it may cause high unspecific background staining and interfere with the specific signal.

Working dilutions for histochemical and cytochemical use are usually between 1: 1 00 and 1: 500; in ELISA and comparable non-precipitating antibody-binding assays between 1 :5,000 and 1 :50,000.
 Product Categories/Family for anti-ALB antibody    Conjugated Secondary Antibody
 Applications Tested/Suitable for anti-ALB antibody   

ELISA (EIA), Immunocytochemistry (IHC), Immunohistochemistry (IHC), Dot Blot (DB), Immunoblotting (IB)

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NCBI/Uniprot data below describe general gene information for ALB. It may not necessarily be applicable to this product.
 NCBI GI #    178344
 NCBI GeneID    213
 NCBI Accession #    AAA98797.1 [Other Products]
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 UniProt Primary Accession #    P02768 [Other Products]
 UniProt Secondary Accession #    O95574; P04277; Q13140; Q645G4; Q68DN5; Q6UXK4; Q86YG0; Q9P157; Q9P1I7; Q9UHS3; Q9UJZ0 [Other Products]
 UniProt Related Accession #    P02768 [Other Products]
 Molecular Weight    69,367 Da [Similar Products]
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 NCBI Official Full Name    albumin
 NCBI Official Synonym Full Names    albumin
 NCBI Official Symbol    ALB [Similar Products]
 NCBI Official Synonym Symbols   
PRO0883; PRO0903; PRO1341
[Similar Products]
 NCBI Protein Information    serum albumin; albumin (32 AA); albumin (AA 34); growth-inhibiting protein 20; cell growth inhibiting protein 42
 UniProt Protein Name    Serum albumin
 Protein Family    Albumin
 UniProt Gene Name    ALB [Similar Products]
 UniProt Entry Name    ALBU_HUMAN
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 NCBI Summary for ALB    Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALB    albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Carrier

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; protein complex; extracellular region; basement membrane; nucleus

Molecular Function: antioxidant activity; toxin binding; protein binding; enzyme binding; copper ion binding; DNA binding; zinc ion binding; chaperone binding; drug binding; oxygen binding; fatty acid binding; pyridoxal phosphate binding

Biological Process: platelet activation; receptor-mediated endocytosis; sodium-independent organic anion transport; maintenance of mitochondrion localization; bile acid metabolic process; hemolysis by symbiont of host red blood cells; lipoprotein metabolic process; cellular response to starvation; bile acid and bile salt transport; response to organic substance; response to mercury ion; retinal homeostasis; platelet degranulation; transport; negative regulation of programmed cell death; blood coagulation; transmembrane transport; positive regulation of circadian sleep/wake cycle, non-REM sleep; response to nutrient; negative regulation of apoptosis

Disease: Analbuminemia; Hyperthyroxinemia, Familial Dysalbuminemic
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 Research Articles on ALB    1. the (1)H-NMR relaxometric study of Mn(II) binding to HSA is reported. Mn(II) binding to HSA is modulated by Zn(II), pH, and myristate through competitive inhibition and allosteric mechanisms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ALB antibodyDiseases associated with anti-ALB antibody
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >258 publications with ALB and Kidney Diseases
 Proteinuria Antibodies  >175 publications with ALB and Proteinuria
 Cardiovascular Diseases Antibodies  >172 publications with ALB and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >164 publications with ALB and Disease Models, Animal
 Liver Cirrhosis Antibodies  >137 publications with ALB and Liver Cirrhosis
 Respiratory Tract Diseases Antibodies  >123 publications with ALB and Respiratory Tract Diseases
 Brain Diseases Antibodies  >91 publications with ALB and Brain Diseases
 Kidney Failure, Chronic Antibodies  >69 publications with ALB and Kidney Failure, Chronic
 Hypertension Antibodies  >68 publications with ALB and Hypertension
 Nephritis Antibodies  >48 publications with ALB and Nephritis
Organs/Tissues associated with anti-ALB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1277 publications with ALB and Blood
 Liver Antibodies  >715 publications with ALB and Liver
 Kidney Antibodies  >349 publications with ALB and Kidney
 Lung Antibodies  >123 publications with ALB and Lung
 Heart Antibodies  >112 publications with ALB and Heart
 Muscle Antibodies  >108 publications with ALB and Muscle
 Spleen Antibodies  >50 publications with ALB and Spleen
 Embryonic Tissue Antibodies  >42 publications with ALB and Embryonic Tissue
 Placenta Antibodies  >8 publications with ALB and Placenta
 Uterus Antibodies  >5 publications with ALB and Uterus
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