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anti-ALDH3A2 antibody :: Rabbit aldehyde dehydrogenase 3 family, member A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712656 anti-ALDH3A2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

aldehyde dehydrogenase 3 family, member A2 (ALDH3A2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human aldehyde dehydrogenase 3 family, member A2 polyclonal Antibody

 Product Synonym Names    aldehyde dehydrogenase 3 family; member A2; ALDH3A2; ALDH10; DKFZp686E23276; FALDH; FLJ20851; SLS
 Product Gene Name   

anti-ALDH3A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609523
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ALDH3A2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74315 / sc-74320 / sc-68892
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ALDH3A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALDH3A2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for ALDH3A2. It may not necessarily be applicable to this product.
 NCBI GI #    12803235
 NCBI GeneID    224
 NCBI Accession #    AAH02430.1 [Other Products]
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 UniProt Secondary Accession #    Q6I9T3; Q93011; Q96J37 [Other Products]
 UniProt Related Accession #    P51648 [Other Products]
 Molecular Weight    57,669 Da [Similar Products]
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 NCBI Official Full Name    Aldehyde dehydrogenase 3 family, member A2
 NCBI Official Synonym Full Names    aldehyde dehydrogenase 3 family, member A2
 NCBI Official Symbol    ALDH3A2 [Similar Products]
 NCBI Official Synonym Symbols   
SLS; FALDH; ALDH10
[Similar Products]
 NCBI Protein Information    fatty aldehyde dehydrogenase; aldehyde dehydrogenase 10; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2
 UniProt Protein Name    Fatty aldehyde dehydrogenase
 UniProt Synonym Protein Names   
Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase
 Protein Family    Fatty aldehyde dehydrogenase
 UniProt Gene Name    ALDH3A2 [Similar Products]
 UniProt Synonym Gene Names    ALDH10; FALDH [Similar Products]
 UniProt Entry Name    AL3A2_HUMAN
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 NCBI Summary for ALDH3A2    Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ALDH3A2    ALDH3A2: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS). SLS is an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization). Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional clinical features include glistening white spots on the retina, seizures, short stature and speech defects. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Membrane protein, integral; EC 1.2.1.3; Amino Acid Metabolism - tryptophan; Mitochondrial; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid; Amino Acid Metabolism - arginine and proline; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Lipid Metabolism - glycerolipid; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - ascorbate and aldarate; Amino Acid Metabolism - histidine; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane; peroxisome

Molecular Function: long-chain-alcohol oxidase activity; aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; long-chain-aldehyde dehydrogenase activity

Biological Process: phytol metabolic process; epidermis development; central nervous system development; aldehyde metabolic process; sesquiterpenoid metabolic process; peripheral nervous system development

Disease: Sjogren-larsson Syndrome
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 Research Articles on ALDH3A2    1. variation in the neurologic phenotype of Sjogren-Larsson syndrome is not strictly determined by the ALDH3A2 mutation or a biochemical defect, but by unidentified epigenetic/environmental factors, gene modifiers, or other mechanisms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ALDH3A2 antibodyDiseases associated with anti-ALDH3A2 antibody
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
 GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies  GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Sjogren-Larsson Syndrome Antibodies  >29 publications with ALDH3A2 and Sjogren-Larsson Syndrome
 Weight Loss Antibodies  >1 publications with ALDH3A2 and Weight Loss
 Hyperplasia Antibodies  >1 publications with ALDH3A2 and Hyperplasia
 Fatty Liver Antibodies  >1 publications with ALDH3A2 and Fatty Liver
Organs/Tissues associated with anti-ALDH3A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >6 publications with ALDH3A2 and Skin
 Eye Antibodies  >5 publications with ALDH3A2 and Eye
 Brain Antibodies  >5 publications with ALDH3A2 and Brain
 Blood Antibodies  >3 publications with ALDH3A2 and Blood
 Liver Antibodies  >2 publications with ALDH3A2 and Liver
 Adipose Tissue Antibodies  >1 publications with ALDH3A2 and Adipose Tissue
 Salivary Gland Antibodies  >1 publications with ALDH3A2 and Salivary Gland
 Spleen Antibodies  >1 publications with ALDH3A2 and Spleen
 Connective Tissue Antibodies  >1 publications with ALDH3A2 and Connective Tissue
 Mouth Antibodies  >1 publications with ALDH3A2 and Mouth
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