P02760
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-1-microglobulin
NCBI Official Synonym Full Names
alpha-1-microglobulin/bikunin precursor
NCBI Official Synonym Symbols
A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC; AMBP [Similar Products]
NCBI Protein Information
protein AMBP; bikunin; uristatin; protein HC; trypstatin; uronic-acid-rich protein; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; complex-forming glycoprotein heterogeneous in charge
UniProt Protein Name
Protein AMBP
UniProt Synonym Protein Names
Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in chargeInter-alpha-trypsin inhibitor light chain; ITI-LC; Alternative name(s):; Bikunin; EDC1; HI-30; Uronic-acid-rich protein
UniProt Synonym Gene Names
UniProt Entry Name
AMBP_HUMAN
NCBI Summary for AMBP
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq]
UniProt Comments for AMBP
AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q32-q33
Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; plasma membrane; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; calcium oxalate binding; IgA binding; heme binding; calcium channel inhibitor activity
Biological Process: receptor-mediated endocytosis; negative regulation of JNK cascade; viral reproduction; heme catabolic process; negative regulation of immune response; protein catabolic process; female pregnancy; cell adhesion; protein-chromophore linkage
Research Articles on AMBP
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Products associated with anti-AMBP antibody
Diseases associated with anti-AMBP antibody
Organs/Tissues associated with anti-AMBP antibody
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