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anti-ctnnb1 antibody :: Rabbit b-Catenin (Tyr-142) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS472004
Unit / Price
0.1 mL  /  $380 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

b-Catenin (Tyr-142) (ctnnb1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-beta-Catenin (Tyr-142), phospho-specific [gamma-Catenin (Tyr-133)]

 Product Synonym Names    b-Catenin (Tyr-142); phospho-specific; Catenin beta
 Product Gene Name   

anti-ctnnb1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_007127.5 (7435502..7458779, complement)
 3D Structure    ModBase 3D Structure for Q7ZU14
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose before affinity purification using phospho- beta -Catenin (Tyr-142) peptide (without carrier). The antibody detects a 92kDa* protein corresponding to the molecular mass of beta -Catenin on SDS-PAGE immunoblots of Hct116 src transformed cells treated with pervanadate, but not in control cells. Similar results were observed in other pervanadate-treated cell lines, such as A431 and human endothelial cells.
 Purity/Purification    Affinity Purified
 Form/Format    Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta-Catenins.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-ctnnb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ctnnb1 antibody

   beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin. The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions. Deletions in the cytoplasmic domain of ECadherin eliminate catenin binding and result in a loss of cell adhesion. Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions. Both Fer and Fyn kinases phosphorylate tyrosine 142 in vitro. Overexpression of these kinases in epithelial cells disrupts interactions between alpha and beta-Catenins. The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin. Src family kinases can also phosphorylate tyrosine 654 in the C terminal armadillo repeat of beta-Catenin. This phosphorylation regulates beta-Catenin binding to E cadherin. Thus, sitespecific tyrosine phosphorylation of beta-Catenin may regulate specific protein-protein interactions leading to changes in cell adhesion.
 Applications Tested/Suitable for anti-ctnnb1 antibody   

ELISA, Western Blot

 Application Notes for anti-ctnnb1 antibody    ELISA: 1:2000
Western Blot: 1:500
ICC: 1:100
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 Testing Data of anti-ctnnb1 antibody    anti-ctnnb1 antibody Testing Data image
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 Immunocytochemistry of anti-ctnnb1 antibody    anti-ctnnb1 antibody Immunocytochemistry (ICC) image
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NCBI/Uniprot data below describe general gene information for ctnnb1. It may not necessarily be applicable to this product.
 NCBI GI #    1125100
 NCBI GeneID    30265
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 UniProt Primary Accession #    Q7ZU14 [Other Products]
 UniProt Related Accession #    Q7ZU14; Q90424 [Other Products]
 Molecular Weight    85,520 Da [Similar Products]
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 NCBI Official Full Name    b-catenin
 NCBI Official Synonym Full Names    catenin (cadherin-associated protein), beta 1
 NCBI Official Symbol    ctnnb1 [Similar Products]
 NCBI Official Synonym Symbols   
ctnnb; id:ibd2058; wu:fb73e10; wu:fi81c06; wu:fk25h01
[Similar Products]
 NCBI Protein Information    catenin beta-1; beta-catenin
 UniProt Protein Name    Catenin (Cadherin-associated protein), beta 1
 Protein Family    Catenin
 UniProt Gene Name    ctnnb1 [Similar Products]
 UniProt Entry Name    Q7ZU14_DANRE
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Product References and Citations for anti-ctnnb1 antibody

   • Brembeck, F.H. et al. (2004) Genes Dev. 18(18):2225-2230.
• Ozawa, M. et al. (1990) Proc. Natl. Acad. Sci. USA 87:4246.
• Piedra, J. et al. (2003) Mol. Cell. Biol. 23(7):2287-2297.
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 Research Articles on ctnnb1    1. maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ctnnb1 antibodyDiseases associated with anti-ctnnb1 antibody
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5482 publications with ctnnb1 and Neoplasms
 Intestinal Neoplasms Antibodies  >1764 publications with ctnnb1 and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >1705 publications with ctnnb1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1286 publications with ctnnb1 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >997 publications with ctnnb1 and Colonic Neoplasms
 Adenoma Antibodies  >680 publications with ctnnb1 and Adenoma
 Liver Neoplasms Antibodies  >627 publications with ctnnb1 and Liver Neoplasms
 Liver Diseases Antibodies  >590 publications with ctnnb1 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >555 publications with ctnnb1 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >521 publications with ctnnb1 and Breast Neoplasms
Organs/Tissues associated with anti-ctnnb1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >897 publications with ctnnb1 and Bone
 Brain Antibodies  >789 publications with ctnnb1 and Brain
 Muscle Antibodies  >585 publications with ctnnb1 and Muscle
 Kidney Antibodies  >584 publications with ctnnb1 and Kidney
 Heart Antibodies  >344 publications with ctnnb1 and Heart
 Eye Antibodies  >264 publications with ctnnb1 and Eye
 Reproductive System Antibodies  >111 publications with ctnnb1 and Reproductive System
 Inner Ear Antibodies  >30 publications with ctnnb1 and Inner Ear
 Fin Antibodies  >21 publications with ctnnb1 and Fin
 Whole Body Antibodies  >20 publications with ctnnb1 and Whole Body
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