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anti-BIRC2 antibody :: Rabbit anti-Human, Mouse baculoviral IAP repeat-containing 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712052 anti-BIRC2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

baculoviral IAP repeat-containing 2 (BIRC2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human baculoviral IAP repeat-containing 2 polyclonal Antibody

 Product Synonym Names    baculoviral IAP repeat-containing 2; BIRC2; API1; HIAP2; Hiap-2; MIHB; RNF48; cIAP1
 Product Gene Name   

anti-BIRC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601712
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human BIRC2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1867 / sc-12410 / sc-7943
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-BIRC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-BIRC2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for BIRC2. It may not necessarily be applicable to this product.
 NCBI GI #    390608637
 NCBI GeneID    329
 NCBI Accession #    NP_001243092.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256163.1 [Other Products]
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 UniProt Secondary Accession #    Q16516; Q4TTG0; B4E026 [Other Products]
 UniProt Related Accession #    Q13490 [Other Products]
 Molecular Weight    64,098 Da [Similar Products]
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 NCBI Official Full Name    baculoviral IAP repeat-containing protein 2 isoform 1
 NCBI Official Synonym Full Names    baculoviral IAP repeat containing 2
 NCBI Official Symbol    BIRC2 [Similar Products]
 NCBI Official Synonym Symbols   
API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
[Similar Products]
 NCBI Protein Information    baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2
 UniProt Protein Name    Baculoviral IAP repeat-containing protein 2
 UniProt Synonym Protein Names   
C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2
 Protein Family    Baculoviral IAP repeat-containing protein
 UniProt Gene Name    BIRC2 [Similar Products]
 UniProt Synonym Gene Names    API1; IAP2; MIHB; RNF48; IAP-2; hIAP-2; hIAP2 [Similar Products]
 UniProt Entry Name    BIRC2_HUMAN
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 NCBI Summary for BIRC2    The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for BIRC2    BIRC2: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin- protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with CASP9. Interacts (via BIR domains) with TRAF2. Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19. Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain- mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination. Belongs to the IAP family.

Protein type: EC 6.3.2.-; Ligase; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q22

Cellular Component: XY body; internal side of plasma membrane; spindle microtubule; cytoplasm; cytosol; nucleus; lipid raft

Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; caspase inhibitor activity; ubiquitin-protein ligase activity; protein N-terminus binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; regulation of toll-like receptor signaling pathway; response to cAMP; protein polyubiquitination; apoptosis; protein heterooligomerization; regulation of cell cycle; toll-like receptor 3 signaling pathway; regulation of apoptosis; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; regulation of cell differentiation; toll-like receptor 4 signaling pathway; cell structure disassembly during apoptosis; placenta development; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; regulation of cell proliferation; regulation of innate immune response; response to ethanol; regulation of inflammatory response; toll-like receptor signaling pathway; response to hypoxia; innate immune response; negative regulation of apoptosis
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 Research Articles on BIRC2    1. Selenite caused CYLD upregulation via LEF1 and cIAP downregulation, both of which contribute to the degradation of ubiquitin chains on RIP1 and subsequent caspase-8 activation and colorectal tumor cell apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-BIRC2 antibodyPathways associated with anti-BIRC2 antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >32 publications with BIRC2 and CASP3
 CASP8 antibody  >21 publications with BIRC2 and CASP8
 TRAF2 antibody  >21 publications with BIRC2 and TRAF2
 DIABLO antibody  >19 publications with BIRC2 and DIABLO
 TRAF1 antibody  >12 publications with BIRC2 and TRAF1
 CASP7 antibody  >7 publications with BIRC2 and CASP7
 RIPK1 antibody  >4 publications with BIRC2 and RIPK1
 TNFRSF1A antibody  >2 publications with BIRC2 and TNFRSF1A
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
Diseases associated with anti-BIRC2 antibodyOrgans/Tissues associated with anti-BIRC2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >48 publications with BIRC2 and Necrosis
 Carcinoma Antibodies  >21 publications with BIRC2 and Carcinoma
 Leukemia Antibodies  >19 publications with BIRC2 and Leukemia
 Carcinoma, Squamous Cell Antibodies  >11 publications with BIRC2 and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >10 publications with BIRC2 and Head and Neck Neoplasms
 Inflammation Antibodies  >10 publications with BIRC2 and Inflammation
 Nervous System Diseases Antibodies  >8 publications with BIRC2 and Nervous System Diseases
 Lung Neoplasms Antibodies  >7 publications with BIRC2 and Lung Neoplasms
 Adenocarcinoma Antibodies  >5 publications with BIRC2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >4 publications with BIRC2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with BIRC2 and Blood
 Lung Antibodies  >12 publications with BIRC2 and Lung
 Vascular Antibodies  >11 publications with BIRC2 and Vascular
 Nerve Antibodies  >8 publications with BIRC2 and Nerve
 Brain Antibodies  >8 publications with BIRC2 and Brain
 Intestine Antibodies  >6 publications with BIRC2 and Intestine
 Prostate Antibodies  >6 publications with BIRC2 and Prostate
 Bone Antibodies  >6 publications with BIRC2 and Bone
 Testis Antibodies  >5 publications with BIRC2 and Testis
 Kidney Antibodies  >4 publications with BIRC2 and Kidney
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