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anti-APOH antibody :: Rabbit beta-2 glycoprotein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS573737 anti-APOH antibody
Unit / Price
1 mL  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta-2 glycoprotein 1 (APOH), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti Human beta-2 glycoprotein 1

 Product Gene Name   

anti-APOH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (64208147..64225556, complement). Location: 17q24.2
 OMIM    138700
 3D Structure    ModBase 3D Structure for P02749
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiserum has not been tested in detail.
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 Specificity    In bidimensional immunoelectrophoresis a single precipitin line is obtained and shows a reaction of full identity with the purified immunogen. The antiserum does not react with any other protein component of human serum or plasma.
 Form/Format    Delipidated, heat inactivated, lyophilized, stable whole serum.
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 Biological origin    Rabbit
 Preservative    No preservative added.
 Immunogen    Beta-2 glycoprotein 1 has a molecular weight of 40,000. The mean concentration in adult serum is about 200 I-1g/ml. Freund's complete adjuvant is used in the first step of the immunization procedure.
 Adsorption    Immunoaffinity adsorbed using insolubilized antigens as required, to eliminate antibodies reacting with other human serum proteins. The use of insolubilized adsorption antigens prevents the presence of excess adsorbent protein or immune complexes in the antiserum.
 Protein concentration    Total protein and IgG concentrations in the antiserum are comparable to those of normal pooled rabbit serum. No foreign proteins added.
 Antibody titre    Measured by quantitative precipitin analysis. The amount of beta2 glycoprotein 1 precipitated by 1ml antiserum is approximately 0.2 mg. Precipitin titre not less than 1:64 when tested against normal human serum in agar-block immunodiffusion titration.
 Directions for use    In immunoelectrophoresis use 2 1-11 human plasma or equivalent against 120 1-11 antiserum. In double radial immunodiffusion use a rosette arrangement with 10 ul antiserum in 3 mm diameter center well and 2 ul plasma samples (neat and serially diluted) in 2 mm diameter peripheral wells. In electroimmunodiffusion use 1 percent antiserum in the gel.
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 Preparation and Storage    Storage / shelf life :
Lyophilized at +4 degree C = at least 10 years
reconstituted at or below -20 degree C = 3-5 years
reconstituted at +4 degree C = 7 days

Handling: The lyophilized antiserum is shipped at ambient temperature and may be stored at +4 degree C; prolonged
storage at or below -20 degree C . Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at +4 degree C, not refrozen, and preferably used the same day.

Caution: This antiserum should be handled by qualified persons only and appropriate precautions should be taken in its handling and disposal, and of all associated materials. For in vitro research purposes only.
 Other Notes    Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APOH antibody

   In precipitating techniques as immunoelectrophoresis and single and double radial immunodiffusion (Mancini, Ouchterlony) and electroimmunodiffusion (Laurell) to identify the presence of beta-2 glycoprotein 1 or to determine its concentration. The presence of non-precipitating antibodies has not been assayed. This does not exclude the use of the antiserum in non-precipitating antibody-binding techniques as ELISA and Western blotting if proper controls are included.
 Product Categories/Family for anti-APOH antibody    Antisera
 Applications Tested/Suitable for anti-APOH antibody   

Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.
 NCBI GI #    153266841
 NCBI GeneID    350
 NCBI Accession #    NP_000033.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000042.2 [Other Products]
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 UniProt Primary Accession #    P02749 [Other Products]
 UniProt Secondary Accession #    Q9UCN7; B2R9M3 [Other Products]
 UniProt Related Accession #    P02749 [Other Products]
 Molecular Weight    38,298 Da [Similar Products]
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 NCBI Official Full Name    beta-2-glycoprotein 1
 NCBI Official Synonym Full Names    apolipoprotein H (beta-2-glycoprotein I)
 NCBI Official Symbol    APOH [Similar Products]
 NCBI Official Synonym Symbols   
BG; B2G1; B2GP1
[Similar Products]
 NCBI Protein Information    beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
 UniProt Protein Name    Beta-2-glycoprotein 1
 UniProt Synonym Protein Names   
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I
 Protein Family    Beta-2-glycoprotein
 UniProt Gene Name    APOH [Similar Products]
 UniProt Synonym Gene Names    B2G1; Apo-H; B2GPI; Beta(2)GPI [Similar Products]
 UniProt Entry Name    APOH_HUMAN
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 NCBI Summary for APOH    Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOH    APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of myeloid cell apoptosis; negative regulation of angiogenesis; triacylglycerol metabolic process; negative regulation of fibrinolysis; positive regulation of blood coagulation; negative regulation of endothelial cell proliferation; negative regulation of blood coagulation; positive regulation of lipoprotein lipase activity; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis
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 Research Articles on APOH    1. IgA antibodies to beta-glycoprotein I are detrimental to the clinical outcome of hemodialysis patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOH antibodyDiseases associated with anti-APOH antibody
 Reference Product  PubMed Publications
 APOA1 antibody  >4 publications with APOH and APOA1
 APOA2 antibody  >2 publications with APOH and APOA2
 APOC3 antibody  >2 publications with APOH and APOC3
 AMBP antibody  >1 publications with APOH and AMBP
 AHSG antibody  >1 publications with APOH and AHSG
 LDLR antibody  >1 publications with APOH and LDLR
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >11 publications with APOH and Autoimmune Diseases
 Liver Diseases Antibodies  >8 publications with APOH and Liver Diseases
 Immune System Diseases Antibodies  >8 publications with APOH and Immune System Diseases
 Brain Diseases Antibodies  >8 publications with APOH and Brain Diseases
 Neoplasms Antibodies  >7 publications with APOH and Neoplasms
 Inflammation Antibodies  >6 publications with APOH and Inflammation
 Hemorrhage Antibodies  >5 publications with APOH and Hemorrhage
 Heart Diseases Antibodies  >5 publications with APOH and Heart Diseases
 Liver Neoplasms Antibodies  >3 publications with APOH and Liver Neoplasms
 Atherosclerosis Antibodies  >3 publications with APOH and Atherosclerosis
Organs/Tissues associated with anti-APOH antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with APOH and Blood
 Liver Antibodies  >20 publications with APOH and Liver
 Brain Antibodies  >4 publications with APOH and Brain
 Muscle Antibodies  >3 publications with APOH and Muscle
 Heart Antibodies  >3 publications with APOH and Heart
 Lung Antibodies  >3 publications with APOH and Lung
 Kidney Antibodies  >3 publications with APOH and Kidney
 Intestine Antibodies  >2 publications with APOH and Intestine
 Embryonic Tissue Antibodies  >1 publications with APOH and Embryonic Tissue
 Spleen Antibodies  >1 publications with APOH and Spleen
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