Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CTNNB1 rightarrow Polyclonal CTNNB1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • bone morphogenetic protein 15 (BMP15) ELISA Kit
 • E Coli Antibody
 • COL19A1 Antibody
 • Glycosylated Ferritin (GF) ELISA Kit
 • Proliferating Cell (PCNA) Recombinant Protein
 • SAPK-JNK Antibody
 • 2,3-Bisphosphoglycerate Mutase (BPGM) Recombinant Protein
 • IP-10-CXCL10 ELISA Kit
 • Cystatin C (CYS-C) ELISA Kit
 • ACOX1 Antibody
 • Asprosin ELISA Kit
 • Interleukin-8 protein (CXCL8) Recombinant Protein
 • Cytokeratin-18 (CK18) Antibody
 • Caspase 9, Cleavage Site (casp9) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CTNNB1 antibody :: Rabbit beta Catenin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175500
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta Catenin (CTNNB1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-beta Catenin antibody

 Product Synonym Names    Catenin beta-1; catenin(cadherin-associated protein), beta 1, 88kDa; b-catenin antibody; Beta catenin antibody; Beta-catenin antibody; Cadherin associated protein antibody; Catenin(cadherin associated protein), beta 1, 88kDa antibody; Catenin beta 1 antibody; Catenin beta-1 antibody; CATNB antibody; CHBCAT antibody; CTNB1_HUMAN antibody; CTNNB antibody; CTNNB1 antibody; DKFZp686D02253 antibod; FLJ25606 antibody; FLJ37923 antibody; OTTHUMP00000162082 antibody; OTTHUMP00000165222 antibody; OTTHUMP00000165223 antibody; OTTHUMP00000209288 antibody; OTTHUMP00000209289 antibody
 Product Gene Name   

anti-CTNNB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS175500 COA    COA PDF
 OMIM    615075
 3D Structure    ModBase 3D Structure for P35222
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Section Bar
 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human beta Catenin (764-781aa DGLPPGDSNQLAWFDTDL), identical to the related rat and mouse sequences.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Section Bar
 Preparation and Storage    At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.

Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CTNNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-CTNNB1 antibody

   Description: Rabbit IgG polyclonal antibody for Catenin beta-1(CTNNB1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Mouse, Rat.

Background: Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Beta-catenin is an adherens junction protein. It plays an important role in various aspects of liver biology including liver development(both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
 Applications Tested/Suitable for anti-CTNNB1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC

 Application Notes for anti-CTNNB1 antibody    Western Blot:

Concentration :0.1-0.5 ug/mL
Tested Species: Human,Mouse,Rat



Immunohistochemistry (Paraffin-embedded Section):

Concentration :0.5--1 ug/mL
Tested Species:Human, Mouse, Rat
Antigen Retrieval: By Heat



Immunohistochemistry (Frozen Section):

Concentration: 0.5-1 ug/mL
Tested Species: Mouse Rat
Predicted Species: Human



Immunohistochemistry:

Concentration : 0.5-1 ug/mL
Tested Species: Human
Predicted Species: Mouse, Rat



Tested Species: In house tested species with positive results.

Predicted Species: Species predicted to be fit for the product bases on sequence similarities.

By Heat: Boling the paraffin sections in 10mM citrate buffer, pH 6.0. for 20 mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested.

Optimal dilutions should be determined by end users.
Section Bar
 Western Blot (WB) of anti-CTNNB1 antibody    Anti-beta Catenin antibody, MBS175500, Western blotting
Lane 1: MM453 Cell Lysate
Lane 2: MCF-7 Cell Lysate
Lane 3: HELA Cell Lysate

anti-CTNNB1 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-CTNNB1 antibody    Anti-beta Catenin antibody, MBS175500, IHC(P)
IHC(P): Human Mammary Cancer Tissue
anti-CTNNB1 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CTNNB1 antibody    Anti-beta Catenin antibody, MBS175500, IHC(F)
IHC(F): Rat Intestine Tissue
anti-CTNNB1 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CTNNB1. It may not necessarily be applicable to this product.
 NCBI GI #    461854
 NCBI GeneID    1499
 NCBI Accession #    P35222.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P35222 [Other Products]
 UniProt Secondary Accession #    Q8NEW9; Q8NI94; Q9H391; A8K1L7 [Other Products]
 UniProt Related Accession #    P35222 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    Catenin beta-1
 NCBI Official Synonym Full Names    catenin (cadherin-associated protein), beta 1, 88kDa
 NCBI Official Symbol    CTNNB1 [Similar Products]
 NCBI Official Synonym Symbols   
CTNNB; MRD19; armadillo
[Similar Products]
 NCBI Protein Information    catenin beta-1
 UniProt Protein Name    Catenin beta-1
 UniProt Synonym Protein Names   
Beta-catenin
 Protein Family    Catenin
 UniProt Gene Name    CTNNB1 [Similar Products]
 UniProt Synonym Gene Names    CTNNB [Similar Products]
 UniProt Entry Name    CTNB1_HUMAN
Section Bar
 NCBI Summary for CTNNB1    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
Section Bar
 UniProt Comments for CTNNB1    CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described.

Protein type: Transcription factor; Motility/polarity/chemotaxis; Cell adhesion; Oncoprotein; Nuclear receptor co-regulator; Actin-binding

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: centrosome; basolateral plasma membrane; intercellular junction; fascia adherens; cytosol; beta-catenin destruction complex; transcription factor complex; cell-cell adherens junction; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; synapse; dendritic shaft; lateral plasma membrane; spindle pole; focal adhesion; tight junction; catenin complex; cell cortex; Z disc; nucleoplasm; adherens junction; microvillus membrane; apical part of cell; plasma membrane; nucleus; cell junction

Molecular Function: protein C-terminus binding; transcription coactivator activity; transcription factor binding; protein phosphatase binding; ionotropic glutamate receptor binding; protein binding; signal transducer activity; enzyme binding; androgen receptor binding; cadherin binding; double-stranded DNA binding; protein complex binding; estrogen receptor binding; nitric-oxide synthase binding; SMAD binding; transcription factor activity; kinase binding; alpha-catenin binding; nuclear hormone receptor binding

Biological Process: regulation of myelination; regulation of centriole-centriole cohesion; positive regulation of apoptosis; protein heterooligomerization; positive regulation of transcription, DNA-dependent; regulation of fibroblast proliferation; cell maturation; negative regulation of chondrocyte differentiation; T cell differentiation in the thymus; positive regulation of fibroblast growth factor receptor signaling pathway; osteoclast differentiation; Wnt receptor signaling pathway through beta-catenin; cell-cell adhesion; positive regulation of endothelial cell differentiation; regulation of cell fate specification; embryonic foregut morphogenesis; positive regulation of mesenchymal cell proliferation; male genitalia development; ectoderm development; synapse organization and biogenesis; cell adhesion; bone resorption; response to drug; positive regulation of neuroblast proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of smooth muscle cell proliferation; transcription, DNA-dependent; hair cell differentiation; negative regulation of protein sumoylation; patterning of blood vessels; genitalia morphogenesis; muscle cell differentiation; midgut development; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; oocyte development; embryonic forelimb morphogenesis; negative regulation of osteoclast differentiation; glial cell fate determination; endodermal cell fate commitment; apoptosis; cell-matrix adhesion; neuron migration; dorsal/ventral axis specification; cell fate specification; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of cell proliferation; central nervous system vasculogenesis; positive regulation of MAPKKK cascade; pancreas development; positive regulation of interferon type I production; fallopian tube development; proximal/distal pattern formation; layer formation in the cerebral cortex; negative regulation of mitotic cell cycle, embryonic; cell structure disassembly during apoptosis; Wnt receptor signaling pathway; hair follicle morphogenesis; thymus development; in utero embryonic development; regulation of T cell proliferation; neural plate development; stem cell maintenance; embryonic axis specification; synaptic vesicle transport; gastrulation with mouth forming second; liver development; regulation of angiogenesis; odontogenesis of dentine-containing teeth; myoblast differentiation; negative regulation of oligodendrocyte differentiation; Schwann cell proliferation; positive regulation of osteoblast differentiation; response to cadmium ion; ureteric bud branching; response to cytokine stimulus; androgen receptor signaling pathway; epithelial to mesenchymal transition; positive regulation of muscle cell differentiation; embryonic heart tube development; innate immune response; lens morphogenesis in camera-type eye; anterior/posterior axis specification

Disease: Pilomatrixoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Colorectal Cancer; Hepatocellular Carcinoma
Table BarTOPTable Bar
 Research Articles on CTNNB1    1. miR-135a/SIAH1/beta-catenin signaling is important in the transformation and progression of cervical carcinoma.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CTNNB1 antibodyPathways associated with anti-CTNNB1 antibody
 Reference Product  PubMed Publications
 APC antibody  >1788 publications with CTNNB1 and APC
 LEF1 antibody  >459 publications with CTNNB1 and LEF1
 TCF7L2 antibody  >359 publications with CTNNB1 and TCF7L2
 AXIN1 antibody  >184 publications with CTNNB1 and AXIN1
 CDH1 antibody  >165 publications with CTNNB1 and CDH1
 CDH2 antibody  >70 publications with CTNNB1 and CDH2
 PSEN1 antibody  >63 publications with CTNNB1 and PSEN1
 BTRC antibody  >37 publications with CTNNB1 and BTRC
 GSK3B antibody  >27 publications with CTNNB1 and GSK3B
 CDH5 antibody  >2 publications with CTNNB1 and CDH5
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with anti-CTNNB1 antibodyOrgans/Tissues associated with anti-CTNNB1 antibody
 Disease Name  Pubmed Publications
 Intestinal Neoplasms Antibodies  >2387 publications with CTNNB1 and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >2305 publications with CTNNB1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1912 publications with CTNNB1 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >1294 publications with CTNNB1 and Colonic Neoplasms
 Liver Neoplasms Antibodies  >958 publications with CTNNB1 and Liver Neoplasms
 Liver Diseases Antibodies  >952 publications with CTNNB1 and Liver Diseases
 Adenoma Antibodies  >950 publications with CTNNB1 and Adenoma
 Neoplasm Invasiveness Antibodies  >851 publications with CTNNB1 and Neoplasm Invasiveness
 Breast Neoplasms Antibodies  >802 publications with CTNNB1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >745 publications with CTNNB1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1645 publications with CTNNB1 and Bone
 Liver Antibodies  >1479 publications with CTNNB1 and Liver
 Brain Antibodies  >1231 publications with CTNNB1 and Brain
 Blood Antibodies  >1190 publications with CTNNB1 and Blood
 Embryonic Tissue Antibodies  >1174 publications with CTNNB1 and Embryonic Tissue
 Vascular Antibodies  >1017 publications with CTNNB1 and Vascular
 Lung Antibodies  >998 publications with CTNNB1 and Lung
 Intestine Antibodies  >956 publications with CTNNB1 and Intestine
 Muscle Antibodies  >931 publications with CTNNB1 and Muscle
 Kidney Antibodies  >818 publications with CTNNB1 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions