AAL28094
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
class III beta tubulin
NCBI Official Synonym Full Names
tubulin, beta 3 class III
NCBI Official Synonym Symbols
CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A [Similar Products]
NCBI Protein Information
tubulin beta-3 chain
UniProt Protein Name
Tubulin beta-3 chain
UniProt Synonym Protein Names
Tubulin beta-4 chain; Tubulin beta-III
UniProt Synonym Gene Names
UniProt Entry Name
TBB3_HUMAN
NCBI Summary for TUBB3
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
UniProt Comments for TUBB3
TUBB3: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Dimer of alpha and beta chains. Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues. Belongs to the tubulin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: microtubule; cell soma; axon; cytoplasm; dendrite; nucleus
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton; peptide binding
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; mitosis; axon guidance; cellular protein metabolic process; protein folding; transmembrane transport; microtubule-based process
Disease: Fibrosis Of Extraocular Muscles, Congenital, 3a, With Or Without Extraocular Involvement; Cortical Dysplasia, Complex, With Other Brain Malformations 1
Research Articles on TUBB3
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Products associated with anti-TUBB3 antibody
Pathways associated with anti-TUBB3 antibody
Diseases associated with anti-TUBB3 antibody
Disease Name |
Pubmed Publications |
Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement Antibodies |
>584 publications with TUBB3 and Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement |
Nervous System Diseases Antibodies |
>79 publications with TUBB3 and Nervous System Diseases |
Brain Diseases Antibodies |
>44 publications with TUBB3 and Brain Diseases |
Breast Neoplasms Antibodies |
>30 publications with TUBB3 and Breast Neoplasms |
Ovarian Neoplasms Antibodies |
>25 publications with TUBB3 and Ovarian Neoplasms |
Disease Models, Animal Antibodies |
>21 publications with TUBB3 and Disease Models, Animal |
Fibrosis Antibodies |
>17 publications with TUBB3 and Fibrosis |
Neoplasms, Experimental Antibodies |
>10 publications with TUBB3 and Neoplasms, Experimental |
Nerve Degeneration Antibodies |
>9 publications with TUBB3 and Nerve Degeneration |
Cardiovascular Diseases Antibodies |
>8 publications with TUBB3 and Cardiovascular Diseases |
Organs/Tissues associated with anti-TUBB3 antibody
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