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anti-APOH antibody :: Goat beta2-Glycoprotein-1 (APO-H) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512023 anti-APOH antibody
Unit / Price
5 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta2-Glycoprotein-1 (APO-H) (APOH), Polyclonal Antibody

 Also Known As   

Goat anti-human Apolipoprotein-H (beta2GPI), Whole IgG from antiserum

 Product Synonym Names    beta2-Glycoprotein-1 (APO-H), human
 Product Gene Name   

anti-APOH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (64208147..64225556, complement). Location: 17q23-qter
 OMIM    138700
 3D Structure    ModBase 3D Structure for P02749
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 Clonality    Polyclonal
 Host    Goat
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 Specificity    This antibody is specific for beta2GPI as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Purified IgG.
Vial containing ml of whole IgG representing approximately 1 ml of antiserum. Total protein is 5 mg.
 Form/Format    Whole IgG, clear liquid.
 Concentration    IgG concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 13.4. (lot specific)
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 Immunogen    Human beta2GPI purified from plasma.
 Buffer    10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol.
 Neutralizing Activity    Not determined
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 Preparation and Storage    Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.
 Other Notes    Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-APOH antibody

   Apolipoprotein-H, also known as beta2-Glycoprotein I (beta2GPI), is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 uM). Synthesized in the liver, beta2GPI is a single chain molecule of 48 kDa, consisting of five repeating internally disulphide-bonded structures referred to as sushi domains. Relative to other glycoproteins, beta2GPI has an unusually high content of cysteine (6.2%), proline (8.3%) and carbohydrate (19%). Almost half the circulating beta2GPI in plasma is associated with lipoproteins of all major fractions. beta2GPI has been demonstrated to bind negatively charged phospholipids, heparin and platelets. Although the precise function(s) are as yet unknown, beta2GPI has been demonstrated to interfere with blood coagulation by competitively binding to negatively charged phospholipid surfaces exposed during cell activation or damage. Recent evidence also implicates beta2GPI as a cofactor recognized by anti-phospholipid antibodies present in some autoimmune disorders such as systemic lupus erythematosus (SLE)1-3.
 Application Notes for anti-APOH antibody    Suitable as a source of antibodies to human beta2GPI.
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NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.
 NCBI GI #    153266841
 NCBI GeneID    350
 NCBI Accession #    NP_000033.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000042.2 [Other Products]
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 UniProt Primary Accession #    P02749 [Other Products]
 UniProt Secondary Accession #    Q9UCN7; B2R9M3 [Other Products]
 UniProt Related Accession #    P02749 [Other Products]
 Molecular Weight    38,298 Da [Similar Products]
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 NCBI Official Full Name    beta-2-glycoprotein 1
 NCBI Official Synonym Full Names    apolipoprotein H (beta-2-glycoprotein I)
 NCBI Official Symbol    APOH [Similar Products]
 NCBI Official Synonym Symbols   
BG; B2G1; B2GP1
[Similar Products]
 NCBI Protein Information    beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
 UniProt Protein Name    Beta-2-glycoprotein 1
 UniProt Synonym Protein Names   
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I
 Protein Family    Beta-2-glycoprotein
 UniProt Gene Name    APOH [Similar Products]
 UniProt Synonym Gene Names    B2G1 [Similar Products]
 UniProt Entry Name    APOH_HUMAN
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 NCBI Summary for APOH    Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq]
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 UniProt Comments for APOH    Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Post-translational modification: N- and O-glycosylated. Ref.10 also reports glycosylation on 'Asn-188' for their allele. Ref.10 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21

Sequence similarities: Contains 4 Sushi (CCP/SCR) domains.
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Product References and Citations for anti-APOH antibody

   1. Lee, NS, Brewer HB Jr., Osborne JC Jr.; beta2Glycoprotein I: Molecular Properties of an Unusual Apolipoprotein, Apolipoprotein H; JBC 258, pp 4765-4770, 1983.
2. Schousboe I; beta2Glycoprotein I: A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway. Blood 66, pp 1 086-1091, 1985.
3. Nimpf J, Bevers EM, Bomans PHH, Till U, Wurm H, Kostner GM, Zwaal RFA; Prothrombinase activity of human platelets is inhibited by beta2Glycoprotein I; Biochimica et Biophysica Acta 884, pp 142-149, 1986.
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 Research Articles on APOH    1. Positive result in a beta2GPI-dependent lupus anticoagulant (LAC) assay correlates better with thrombosis than the classic LAC assay.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOH antibodyDiseases associated with anti-APOH antibody
 Reference Product  PubMed Publications
 PLG antibody  >1 publications with APOH and PLG
 LPA antibody  >1 publications with APOH and LPA
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >16 publications with APOH and Vascular Diseases
 Liver Diseases Antibodies  >7 publications with APOH and Liver Diseases
 Myocardial Ischemia Antibodies  >6 publications with APOH and Myocardial Ischemia
 Neoplasms Antibodies  >5 publications with APOH and Neoplasms
 Inflammation Antibodies  >4 publications with APOH and Inflammation
 Hemorrhage Antibodies  >4 publications with APOH and Hemorrhage
 Hypertension Antibodies  >3 publications with APOH and Hypertension
 Liver Neoplasms Antibodies  >3 publications with APOH and Liver Neoplasms
 Atherosclerosis Antibodies  >3 publications with APOH and Atherosclerosis
 Arteriosclerosis Antibodies  >3 publications with APOH and Arteriosclerosis
Organs/Tissues associated with anti-APOH antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with APOH and Blood
 Liver Antibodies  >19 publications with APOH and Liver
 Brain Antibodies  >3 publications with APOH and Brain
 Muscle Antibodies  >3 publications with APOH and Muscle
 Lung Antibodies  >3 publications with APOH and Lung
 Kidney Antibodies  >3 publications with APOH and Kidney
 Intestine Antibodies  >2 publications with APOH and Intestine
 Heart Antibodies  >2 publications with APOH and Heart
 Spleen Antibodies  >1 publications with APOH and Spleen
 Connective Tissue Antibodies  >1 publications with APOH and Connective Tissue
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