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anti-c-Fos antibody :: Rabbit c-Fos Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440023
Western Blot (WB)
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Fos, Polyclonal Antibody

 Also Known As   

c-Fos (A14) Antibody

 Product Gene Name   

anti-c-Fos antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164810
 3D Structure    ModBase 3D Structure for P01100
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, rat, human
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 Specificity    Mouse, rat and human c-Fos
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    c-Fos (A14) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of human c-Fos.
 Immunogen    Synthetic peptide mapping to the amino terminus of human c-Fos.
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-c-Fos antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-c-Fos antibody

   The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4).
 Applications Tested/Suitable for anti-c-Fos antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-c-Fos antibody    c-Fos (A14) DB025 reacts with c-Fos of mouse, rat and human origin by western blotting, immunoprecipitation and immunohistochemistry. Western blotting starting dilution: 1:200.
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 Western Blot (WB) of anti-c-Fos antibody    anti-c-Fos antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for c-Fos. It may not necessarily be applicable to this product.
 NCBI GI #    29904
 NCBI GeneID    2353
 NCBI Accession #    CAA24756.1 [Other Products]
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 UniProt Primary Accession #    P01100 [Other Products]
 UniProt Secondary Accession #    P18849; A8K4E2; B4DQ65 [Other Products]
 UniProt Related Accession #    P01100 [Other Products]
 Molecular Weight    36,301 Da
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 NCBI Official Full Name    c-fos
 NCBI Official Synonym Full Names    FBJ murine osteosarcoma viral oncogene homolog
 NCBI Official Symbol    FOS [Similar Products]
 NCBI Official Synonym Symbols   
p55; AP-1; C-FOS
[Similar Products]
 NCBI Protein Information    proto-oncogene c-Fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); G0/G1 switch regulatory protein 7; activator protein 1; cellular oncogene c-fos
 UniProt Protein Name    Proto-oncogene c-Fos
 UniProt Synonym Protein Names   
Cellular oncogene fos; G0/G1 switch regulatory protein 7
 UniProt Gene Name    FOS [Similar Products]
 UniProt Synonym Gene Names    G0S7 [Similar Products]
 UniProt Entry Name    FOS_HUMAN
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 NCBI Summary for c-Fos    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]
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 UniProt Comments for c-Fos    Fos: a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.

Protein type: Transcription factor; Motility/polarity/chemotaxis; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: nucleoplasm; transcription factor complex; neuron projection; membrane; endoplasmic reticulum; cytosol; nucleus

Molecular Function: protein binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; response to gravity; response to cAMP; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; response to toxin; stress-activated MAPK cascade; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; female pregnancy; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; conditioned taste aversion; transforming growth factor beta receptor signaling pathway; DNA methylation; inflammatory response; toll-like receptor 4 signaling pathway; response to corticosterone stimulus; aging; response to drug; nervous system development; response to light stimulus; MyD88-independent toll-like receptor signaling pathway; sleep; toll-like receptor 2 signaling pathway; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; response to mechanical stimulus; response to cytokine stimulus; cellular response to extracellular stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; toll-like receptor 9 signaling pathway; response to progesterone stimulus
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Product References and Citations for anti-c-Fos antibody

   1. Karin M, Liu Zg, Zandi E. AP-1 function and regulation.Curr Opin Cell Biol. 1997 Apr;9(2):240-6. 2. Bos TJ, Rauscher FJ 3rd, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb;4(2):123-6.3. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30;20(19):2390-400.4. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol. 1998 Mar;12(3):685-7005. Curran T. Fos and Jun: oncogenic transcription factors.Tohoku J Exp Med. 1992 Oct;168(2):169-74.6. Rauscher FJ 3rd, Voulalas PJ, Franza BR Jr, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec;2(12B):1687-99.
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 Research Articles on c-Fos    1. Data suggest that p38 MAP kinase regulates c-Fos/cellular oncogene fos mRNA stability/decay by affecting state of phosphorylation of ELAVL1/HuR (Hu antigen R).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-c-Fos antibodyPathways associated with anti-c-Fos antibody
 Reference Product  PubMed Publications
 JUN antibody  >8192 publications with c-Fos and JUN
 JUNB antibody  >711 publications with c-Fos and JUNB
 JUND antibody  >503 publications with c-Fos and JUND
 MAPK1 antibody  >450 publications with c-Fos and MAPK1
 SRF antibody  >272 publications with c-Fos and SRF
 RHOA antibody  >72 publications with c-Fos and RHOA
 CREB1 antibody  >55 publications with c-Fos and CREB1
 MAPK8 antibody  >45 publications with c-Fos and MAPK8
 SMAD3 antibody  >37 publications with c-Fos and SMAD3
 NFATC2 antibody  >19 publications with c-Fos and NFATC2
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
Diseases associated with anti-c-Fos antibodyOrgans/Tissues associated with anti-c-Fos antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2859 publications with c-Fos and Nervous System Diseases
 Pain Antibodies  >1441 publications with c-Fos and Pain
 Inflammation Antibodies  >1020 publications with c-Fos and Inflammation
 Necrosis Antibodies  >755 publications with c-Fos and Necrosis
 Epilepsy Antibodies  >526 publications with c-Fos and Epilepsy
 Seizures Antibodies  >509 publications with c-Fos and Seizures
 Hyperalgesia Antibodies  >402 publications with c-Fos and Hyperalgesia
 Hypertension Antibodies  >380 publications with c-Fos and Hypertension
 Liver Diseases Antibodies  >377 publications with c-Fos and Liver Diseases
 Breast Neoplasms Antibodies  >369 publications with c-Fos and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11126 publications with c-Fos and Brain
 Blood Antibodies  >3636 publications with c-Fos and Blood
 Nerve Antibodies  >2602 publications with c-Fos and Nerve
 Muscle Antibodies  >1480 publications with c-Fos and Muscle
 Spinal Cord Antibodies  >1460 publications with c-Fos and Spinal Cord
 Bone Antibodies  >1267 publications with c-Fos and Bone
 Vascular Antibodies  >1181 publications with c-Fos and Vascular
 Liver Antibodies  >1001 publications with c-Fos and Liver
 Heart Antibodies  >949 publications with c-Fos and Heart
 Skin Antibodies  >689 publications with c-Fos and Skin
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