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anti-c-Jun antibody :: Rabbit c-Jun Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440024
Western Blot (WB)
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Jun, Polyclonal Antibody

 Also Known As   

c-Jun (A15) Antibody

 Product Gene Name   

anti-c-Jun antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q4ZJE9
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, rat, human
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 Specificity    Mouse, rat and human c-Jun p39
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    c-Jun (A15) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of mouse c-Jun p39.
 Immunogen    Synthetic peptide mapping to the amino terminus of mouse c-Jun p39.
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-c-Jun antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-c-Jun antibody

   The products of the proto-oncogenes c-Jun (c-Jun was previously known as the Fos-binding protein p39) and c-Fos are known to form a complex in the nucleus (2, 6). AP-1 (activating protein-1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site (1). There is evidence that AP-1 proteins, mostly those that belong to the Jun group, control cell life and death through their ability to regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16 (3). The Fos and Jun proto-oncogenes expression is induced transiently by a great variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons (5). Studies have established a unique role for Fos in determining the differentiation and activity of progenitors of the osteoclast lineage (4). c-Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of c-Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of c-Jun probably results from transcriptional deregulation of v-Jun-responsive target genes (7).
 Applications Tested/Suitable for anti-c-Jun antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-c-Jun antibody    c-Jun DB026 (A14) reacts with c-Jun p39 of mouse, rat and human origin by western blotting, immunoprecipitation and immunohistochemistry. Western blotting starting dilution: 1:200.
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 Western Blot (WB) of anti-c-Jun antibody    anti-c-Jun antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for c-Jun. It may not necessarily be applicable to this product.
 NCBI GI #    41053401
 NCBI GeneID    335916
 NCBI Accession #    NP_956281.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199987.1 [Other Products]
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 UniProt Primary Accession #    Q4ZJE9 [Other Products]
 Molecular Weight    33,849 Da
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 NCBI Official Full Name    transcription factor AP-1
 NCBI Official Synonym Full Names    jun proto-oncogene
 NCBI Official Symbol    jun [Similar Products]
 NCBI Official Synonym Symbols   
c-Jun; fj36h07; zgc:65863; wu:fj36h07
[Similar Products]
 NCBI Protein Information    transcription factor AP-1; v-jun sarcoma virus 17 oncogene homolog
 UniProt Protein Name    C-Jun
 UniProt Synonym Protein Names   
 Protein Family    C-Jun-amino-terminal kinase-interacting protein
 UniProt Gene Name    jun [Similar Products]
 UniProt Entry Name    Q4ZJE9_DANRE
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Product References and Citations for anti-c-Jun antibody

   1.) Himes SR, Sester DP, Ravasi T, Cronau SL, Sasmono T, Hume DA. 2006. The JNK are important for development and survival of macrophages. J Immunol. Feb 15;176(4):2219-28.2.) Dann SG, Ted Allison W, Veldhoen K, Johnson T, Hawryshyn CW. 2004. Chromatin immunoprecipitation assay on the rainbow trout opsin proximal promoters illustrates binding of NF-kappaB and c-jun to the SWS1 promoter in the retina. Exp Eye Res. May;78(5):1015-24.

1. Karin M, Liu Zg, Zandi E. AP-1 function and regulation.Curr Opin Cell Biol. 1997 Apr;9(2):240-6.2. Bos TJ, Rauscher FJ 3rd, Curran T, Vogt PK. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene. 1989 Feb;4(2):123-6.3. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30;20(19):2390-400.4. Liebermann DA, Gregory B, Hoffman B. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol. 1998 Mar;12(3):685-7005. Curran T. Fos and Jun: oncogenic transcription factors.Tohoku J Exp Med. 1992 Oct;168(2):169-74.6. Rauscher FJ 3rd, Voulalas PJ, Franza BR Jr, Curran T. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 1988 Dec;2(12B):1687-99.7. Fu Sl, Bottoli I, Goller M, Vogt PK. Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5716-21.
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 Research Articles on c-Jun    1. CPEB-1 control of c-Jun mRNA translation regulates GH gene expression and resulting downstream signaling events (e.g., synaptic plasticity) in the mouse hippocampus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-c-Jun antibodyPathways associated with anti-c-Jun antibody
 Reference Product  PubMed Publications
 fos antibody  >8192 publications with c-Jun and fos
 atf3 antibody  >210 publications with c-Jun and atf3
 mapk9 antibody  >12 publications with c-Jun and mapk9
 mapk10 antibody  >5 publications with c-Jun and mapk10
 mapk11 antibody  >2 publications with c-Jun and mapk11
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ERK1 - ERK2 MAPK Cascade Pathway antibodies  ERK1 - ERK2 MAPK Cascade Pathway Diagram
Organs/Tissues associated with anti-c-Jun antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >131047 publications with c-Jun and Brain
 Heart Antibodies  >102728 publications with c-Jun and Heart
 Liver Antibodies  >80983 publications with c-Jun and Liver
 Muscle Antibodies  >78449 publications with c-Jun and Muscle
 Kidney Antibodies  >59564 publications with c-Jun and Kidney
 Skin Antibodies  >56688 publications with c-Jun and Skin
 Eye Antibodies  >43378 publications with c-Jun and Eye
 Whole Body Antibodies  >6471 publications with c-Jun and Whole Body
 Fin Antibodies  >1044 publications with c-Jun and Fin
 Gills Antibodies  >876 publications with c-Jun and Gills
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