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anti-C-JUN antibody :: Rabbit c-Jun Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628660 anti-C-JUN antibody
Unit / Price
0.1 mL  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Jun, Polyclonal Antibody

 Also Known As   

c-Jun, phosphorylated (Thr91, Thr93)

 Product Synonym Names    Anti -c-Jun, phosphorylated (Thr91, Thr93)
 Product Gene Name   

anti-C-JUN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_010448.2 (141029845..141031055)
 3D Structure    ModBase 3D Structure for P56432
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Avian, Bovine, Human, Mouse, Porcine, Rabbit, Rat
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 Specificity    Recognizes phosphorylated c-Jun (Thr91/Thr93), Mr 41kD. An additional unknown protein was also detected, Mr 65kD. Species Crossreactivity: Human and mouse. Predicted to crossreact with avian, rat, rabbit, bovine and porcine based on sequence homology.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in 0.2M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide before the addition of glycerol to 30%.
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 Immunogen    KLH-conjugated, synthetic peptide corresponding to aa85-101 (NGHITT[pT]P[pT]PTQFLCPK) of human c-Jun. The immunizing sequence is identical in mouse and rat.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-C-JUN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-C-JUN antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-C-JUN antibody   

Western Blot (WB)

 Application Notes for anti-C-JUN antibody    Suitable for use in Western Blot.
Dilution: Immunoblot Analysis: A 1:1000 dilution of this lot detected phosphorylated c-Jun in RIPA lysates from 3T3 cells stimulated with 10ug/ml anisomycin for 30 minutes.
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NCBI/Uniprot data below describe general gene information for C-JUN. It may not necessarily be applicable to this product.
 NCBI GI #    1911701
 NCBI GeneID    396913
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 UniProt Primary Accession #    P56432 [Other Products]
 UniProt Related Accession #    P56432 [Other Products]
 Molecular Weight    35,629 Da [Similar Products]
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 NCBI Official Full Name    c-Jun
 NCBI Official Symbol    C-JUN [Similar Products]
 NCBI Official Synonym Symbols   
Jun
[Similar Products]
 NCBI Protein Information    transcription factor AP-1; AP1; activator protein 1; proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog
 UniProt Protein Name    Transcription factor AP-1
 UniProt Synonym Protein Names   
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog
 Protein Family    C-Jun-amino-terminal kinase-interacting protein
 UniProt Gene Name    JUN [Similar Products]
 UniProt Entry Name    JUN_PIG
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 UniProt Comments for C-JUN    Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Subunit structure: Heterodimer with either FOS or BATF3 or ATF7

By similarity. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex

By similarity. Interacts with RNF187

Subcellular location: Nucleus

Post-translational modification: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC

Sequence similarities: Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-C-JUN antibodyDiseases associated with anti-C-JUN antibody
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Death Antibodies  >3084 publications with C-JUN and Death
 Necrosis Antibodies  >2383 publications with C-JUN and Necrosis
 Nervous System Diseases Antibodies  >1241 publications with C-JUN and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >946 publications with C-JUN and Central Nervous System Diseases
 Brain Diseases Antibodies  >936 publications with C-JUN and Brain Diseases
 Disease Models, Animal Antibodies  >913 publications with C-JUN and Disease Models, Animal
 Immune System Diseases Antibodies  >653 publications with C-JUN and Immune System Diseases
 Liver Diseases Antibodies  >645 publications with C-JUN and Liver Diseases
 Lung Diseases Antibodies  >467 publications with C-JUN and Lung Diseases
 Immunoproliferative Disorders Antibodies  >314 publications with C-JUN and Immunoproliferative Disorders
Organs/Tissues associated with anti-C-JUN antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2390 publications with C-JUN and Blood
 Brain Antibodies  >2268 publications with C-JUN and Brain
 Muscle Antibodies  >1453 publications with C-JUN and Muscle
 Lung Antibodies  >901 publications with C-JUN and Lung
 Heart Antibodies  >771 publications with C-JUN and Heart
 Skin Antibodies  >632 publications with C-JUN and Skin
 Embryonic Tissue Antibodies  >372 publications with C-JUN and Embryonic Tissue
 Intestine Antibodies  >251 publications with C-JUN and Intestine
 Joint Antibodies  >210 publications with C-JUN and Joint
 Stomach Antibodies  >143 publications with C-JUN and Stomach
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