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anti-c-Src antibody :: Rabbit c-Src Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440022 anti-c-Src antibody
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Src, Polyclonal Antibody

 Also Known As   

c-Src (A16) Antibody

 Product Gene Name   

anti-c-Src antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190090
 3D Structure    ModBase 3D Structure for P12931
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, rat, human
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 Specificity    Mouse, rat and human cSrc
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    c-Src (A16) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of human c-Src p60.
 Immunogen    Synthetic peptide mapping to the amino terminus of human c-Src p60.
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-c-Src antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-c-Src antibody

   The Src gene family is represented by at least eight different protein tyrosine kinases belonging to the non-receptor tyrosine kinases (1,2). These protein tyrosine kinases are important regulators of many cellular processes, including cytoskeletal organization, cell-cell contact, DNA synthesis, and cellular proliferation (1-3). Members of this group of proteins include c-Src, c-Yes, Fyn, Lck, Lyn, Hck, Blk and c-Fgr. The proto-oncogene c-Src is the prototype member of this gene family and is expressed in a broad range of tissues and cells (4,5). Elevated c-Src tyrosine kinase activity has been found in many types of human cancers, most notably in breast carcinomas (6,7). The activity of c-Src in these human cancers has been attributed to increases c-Src expression, elevated c-Src specific activity and activating mutations in c-Src (6,7).
 Applications Tested/Suitable for anti-c-Src antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-c-Src antibody    Western blotting starting dilution: 1:200.
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NCBI/Uniprot data below describe general gene information for c-Src. It may not necessarily be applicable to this product.
 NCBI GI #    1848077
 NCBI GeneID    6714
 NCBI Accession #    CAA26485.1 [Other Products]
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 UniProt Primary Accession #    P12931 [Other Products]
 UniProt Secondary Accession #    Q76P87; Q86VB9; Q9H5A8; E1P5V4 [Other Products]
 UniProt Related Accession #    P12931 [Other Products]
 Molecular Weight    60,589 Da
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 NCBI Official Full Name    c-src, partial
 NCBI Official Synonym Full Names    SRC proto-oncogene, non-receptor tyrosine kinase
 NCBI Official Symbol    SRC [Similar Products]
 NCBI Official Synonym Symbols   
ASV; SRC1; c-SRC; p60-Src
[Similar Products]
 NCBI Protein Information    proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
 UniProt Protein Name    Proto-oncogene tyrosine-protein kinase Src
 UniProt Synonym Protein Names   
Proto-oncogene c-Src; pp60c-src; p60-Src
 UniProt Gene Name    SRC [Similar Products]
 UniProt Synonym Gene Names    SRC1; p60-Src [Similar Products]
 UniProt Entry Name    SRC_HUMAN
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 NCBI Summary for c-Src    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for c-Src    Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q12-q13

Cellular Component: neuron projection; mitochondrion; lysosome; postsynaptic density; actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; late endosome; mitochondrial inner membrane; plasma membrane; nucleus

Molecular Function: protein C-terminus binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; insulin receptor binding; protein kinase activity; integrin binding; protein binding; enzyme binding; protein kinase C binding; SH3/SH2 adaptor activity; protein-tyrosine kinase activity; heme binding; estrogen receptor binding; kinase activity; SH2 domain binding; ATP binding; hormone receptor binding; receptor binding

Biological Process: oogenesis; regulation of estrogen receptor signaling pathway; estrogen receptor signaling pathway; progesterone receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; central nervous system development; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; regulation of cell cycle; positive regulation of transcription, DNA-dependent; uterus development; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; positive regulation of MAP kinase activity; cell-cell adhesion; transforming growth factor beta receptor signaling pathway; response to electrical stimulus; cell adhesion; bone resorption; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; response to virus; activation of protein kinase B; transcytosis; positive regulation of integrin activation; positive regulation of protein amino acid autophosphorylation; cellular response to insulin stimulus; response to mechanical stimulus; T cell costimulation; regulation of vascular permeability; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of apoptosis; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; negative regulation of caspase activity; positive regulation of smooth muscle cell migration; signal transduction; regulation of cell-cell adhesion; forebrain development; ephrin receptor signaling pathway; integrin-mediated signaling pathway; response to nutrient levels; epidermal growth factor receptor signaling pathway; regulation of bone resorption; negative regulation of focal adhesion formation; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; response to mineralocorticoid stimulus; cell cycle; regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; response to hydrogen peroxide; regulation of protein binding; Ras protein signal transduction; stress fiber formation; innate immune response; positive regulation of insulin receptor signaling pathway; response to acidity; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cytokine secretion
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Product References and Citations for anti-c-Src antibody

   1.)Ardizzone TD, Zhan X, Ander BP, Sharp FR. 2007, SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhage. Stroke. 2007 May;38(5):1621-5.

1. Oda H, Kumar S, Howley PM. 1999. Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination. Proc Natl Acad Sci USA 96(17):9557-9562. 2. Biscardi JS, Ishizawar RC, Silva CM, Parsons SJ. 2000. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interaction in breast cancer. Breast Cancer Res 2(3):203-210.3. Ingraham CA, Cox ME, Ward DC, Fults DW, Maness PF. 1989. c-Src and other proto-oncogenes implicated in neuronal differentiation. Mol Chem Neuropathol 10(1):1-14.4. Wiestler OD, Walter G. 1988. Developmental expression of two forms of pp60c-src in mouse brain. Mol Cell Biol 8(1):502-504.5. Yang XM, Martinez R, Le Beau J, Wiestler O, Walter G. Evolutionary expression of the neuronal form of the src protein. Proc Natl Acad Sci USA 86(12):4751-4755.6. Bjorge JD, Pang A, Fujita DJ. 2000. Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines. J Biol Chem 275(52):41439-41446.7. Hung W, Elliot B. 2001. Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells. J Biol Chem 276(15):12395-12403.
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 Research Articles on c-Src    1. Membrane AR activation regulates late expression and/or activity of the tumorigenic gene products c-Src, GSK-3beta. and beta-catenin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-c-Src antibodyPathways associated with anti-c-Src antibody
 Reference Product  PubMed Publications
 EGFR antibody  >1286 publications with c-Src and EGFR
 STAT3 antibody  >840 publications with c-Src and STAT3
 CRK antibody  >647 publications with c-Src and CRK
 PTK2 antibody  >626 publications with c-Src and PTK2
 CBL antibody  >506 publications with c-Src and CBL
 PXN antibody  >175 publications with c-Src and PXN
 BCAR1 antibody  >168 publications with c-Src and BCAR1
 KHDRBS1 antibody  >86 publications with c-Src and KHDRBS1
 PTPN1 antibody  >73 publications with c-Src and PTPN1
 ESR1 antibody  >13 publications with c-Src and ESR1
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
Diseases associated with anti-c-Src antibodyOrgans/Tissues associated with anti-c-Src antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1916 publications with c-Src and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1111 publications with c-Src and Breast Neoplasms
 Inflammation Antibodies  >878 publications with c-Src and Inflammation
 Disease Models, Animal Antibodies  >846 publications with c-Src and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >795 publications with c-Src and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >787 publications with c-Src and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >719 publications with c-Src and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >676 publications with c-Src and Neoplasm Metastasis
 Necrosis Antibodies  >624 publications with c-Src and Necrosis
 Neoplasm Invasiveness Antibodies  >584 publications with c-Src and Neoplasm Invasiveness
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5266 publications with c-Src and Blood
 Brain Antibodies  >2105 publications with c-Src and Brain
 Muscle Antibodies  >1625 publications with c-Src and Muscle
 Bone Antibodies  >1381 publications with c-Src and Bone
 Kidney Antibodies  >1171 publications with c-Src and Kidney
 Lung Antibodies  >1108 publications with c-Src and Lung
 Nerve Antibodies  >1065 publications with c-Src and Nerve
 Liver Antibodies  >909 publications with c-Src and Liver
 Embryonic Tissue Antibodies  >540 publications with c-Src and Embryonic Tissue
 Prostate Antibodies  >517 publications with c-Src and Prostate
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