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anti-cPLA2 antibody :: Rabbit cPLA2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS248544
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cPLA2, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human cPLA2

 Product Synonym Names    Anti-cPLA2 Antibody (aa480-530) IHC-plus; Human cPLA2
 Product Gene Name   

anti-cPLA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600522
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human cPLA2
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, pH 7.2, 0.05% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide around Asn499 of human cPLA2
 Immunogen Type    Synthetic peptide
 Antigen Modification    aa480-530
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 Preparation and Storage    Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-cPLA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-cPLA2 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-cPLA2 antibody    IF, IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-cPLA2 antibody    Anti-cPLA2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-cPLA2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-cPLA2 antibody    Western blot anylsis of c-PLA2 pAb at a 1:500 dilution. Lane 1: HEK293T whoe cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
anti-cPLA2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for cPLA2. It may not necessarily be applicable to this product.
 NCBI GI #    23943920
 NCBI GeneID    5321
 NCBI Accession #    NP_077734.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_024420.2 [Other Products]
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 UniProt Secondary Accession #    Q29R80; B1AKG4 [Other Products]
 UniProt Related Accession #    P47712 [Other Products]
 Molecular Weight    85,239 Da
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 NCBI Official Full Name    cytosolic phospholipase A2
 NCBI Official Synonym Full Names    phospholipase A2, group IVA (cytosolic, calcium-dependent)
 NCBI Official Symbol    PLA2G4A [Similar Products]
 NCBI Official Synonym Symbols   
PLA2G4; cPLA2-alpha
[Similar Products]
 NCBI Protein Information    cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein
 UniProt Protein Name    Cytosolic phospholipase A2
 UniProt Synonym Protein Names   
Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
 UniProt Gene Name    PLA2G4A [Similar Products]
 UniProt Synonym Gene Names    CPLA2; PLA2G4; cPLA2 [Similar Products]
 UniProt Entry Name    PA24A_HUMAN
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 NCBI Summary for cPLA2    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
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 UniProt Comments for cPLA2    cPLA2: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A.

Protein type: Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4; Lipid Metabolism - linoleic acid; EC 3.1.1.5; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; cytoplasm; cytoplasmic membrane-bound vesicle; mitochondrial inner membrane; cytosol

Molecular Function: phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-dependent phospholipase A2 activity; calcium ion binding; lysophospholipase activity

Biological Process: icosanoid biosynthetic process; platelet activating factor biosynthetic process; platelet activation; phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; icosanoid metabolic process; phosphatidic acid biosynthetic process; arachidonic acid metabolic process; arachidonic acid secretion; blood coagulation; regulation of cell proliferation
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 Research Articles on cPLA2    1. Data indicate 3-(1-Aryl-1H-indol-5-yl)propanoic acids a potent inhibitor of cytosolic phospholipase A2alpha (cPLA2alpha).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-cPLA2 antibodyPathways associated with anti-cPLA2 antibody
 Reference Product  PubMed Publications
 PTGS2 antibody  >307 publications with cPLA2 and PTGS2
 PLA2G6 antibody  >107 publications with cPLA2 and PLA2G6
 PTGS1 antibody  >95 publications with cPLA2 and PTGS1
 ALOX5 antibody  >62 publications with cPLA2 and ALOX5
 SYK antibody  >8 publications with cPLA2 and SYK
 PLD2 antibody  >4 publications with cPLA2 and PLD2
 KAT5 antibody  >2 publications with cPLA2 and KAT5
 MKNK1 antibody  >1 publications with cPLA2 and MKNK1
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
Diseases associated with anti-cPLA2 antibodyOrgans/Tissues associated with anti-cPLA2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >314 publications with cPLA2 and Inflammation
 Necrosis Antibodies  >174 publications with cPLA2 and Necrosis
 Nervous System Diseases Antibodies  >146 publications with cPLA2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >121 publications with cPLA2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >112 publications with cPLA2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >35 publications with cPLA2 and Lung Neoplasms
 Edema Antibodies  >35 publications with cPLA2 and Edema
 Heart Diseases Antibodies  >33 publications with cPLA2 and Heart Diseases
 Liver Diseases Antibodies  >29 publications with cPLA2 and Liver Diseases
 Pain Antibodies  >27 publications with cPLA2 and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >282 publications with cPLA2 and Brain
 Vascular Antibodies  >216 publications with cPLA2 and Vascular
 Lung Antibodies  >200 publications with cPLA2 and Lung
 Kidney Antibodies  >145 publications with cPLA2 and Kidney
 Embryonic Tissue Antibodies  >64 publications with cPLA2 and Embryonic Tissue
 Ovary Antibodies  >46 publications with cPLA2 and Ovary
 Eye Antibodies  >45 publications with cPLA2 and Eye
 Uterus Antibodies  >41 publications with cPLA2 and Uterus
 Skin Antibodies  >37 publications with cPLA2 and Skin
 Intestine Antibodies  >36 publications with cPLA2 and Intestine
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