P19429.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,008 Da
NCBI Official Full Name
Troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I3, cardiac type
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF [Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
UniProt Synonym Gene Names
UniProt Entry Name
TNNI3_HUMAN
NCBI Summary for TNNI3
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
UniProt Comments for TNNI3
TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: cytosol; sarcomere; troponin complex
Molecular Function: actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding
Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle filament sliding; negative regulation of ATPase activity; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Dilated, 2a; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Familial Restrictive, 1
Research Articles on TNNI3
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Pathways associated with anti-TNNI3 antibody
Diseases associated with anti-TNNI3 antibody
Disease Name |
Pubmed Publications |
Heart Diseases Antibodies |
>89 publications with TNNI3 and Heart Diseases |
Cardiomyopathies Antibodies |
>80 publications with TNNI3 and Cardiomyopathies |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>31 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial |
Cardiomyopathy, Dilated Antibodies |
>25 publications with TNNI3 and Cardiomyopathy, Dilated |
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies |
>10 publications with TNNI3 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 |
Cardiomyopathy, Restrictive Antibodies |
>10 publications with TNNI3 and Cardiomyopathy, Restrictive |
Nervous System Diseases Antibodies |
>6 publications with TNNI3 and Nervous System Diseases |
Ventricular Dysfunction, Left Antibodies |
>6 publications with TNNI3 and Ventricular Dysfunction, Left |
Fibrosis Antibodies |
>6 publications with TNNI3 and Fibrosis |
Hypertension Antibodies |
>5 publications with TNNI3 and Hypertension |
Organs/Tissues associated with anti-TNNI3 antibody
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