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anti-CASR antibody :: Rabbit calcium-sensing receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714825 anti-CASR antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

calcium-sensing receptor (CASR), Polyclonal Antibody

 Also Known As   

Rabbit anti-human calcium-sensing receptor polyclonal Antibody

 Product Synonym Names    calcium-sensing receptor; CASR; CAR; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; PCAR1
 Product Gene Name   

anti-CASR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene+612899
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CASR
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32180 / sc-32181 / sc-32182 / sc-33821
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CASR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CASR antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
 NCBI GI #    85567661
 NCBI GeneID    846
 NCBI Accession #    AAI12237.1 [Other Products]
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 UniProt Secondary Accession #    Q13912; Q16108; Q16109; Q16110; Q16379; Q2M1T0; Q4PJ19 [Other Products]
 UniProt Related Accession #    P41180 [Other Products]
 Molecular Weight    121,772 Da [Similar Products]
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 NCBI Official Full Name    Calcium-sensing receptor
 NCBI Official Synonym Full Names    calcium-sensing receptor
 NCBI Official Symbol    CASR [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor 1
 UniProt Protein Name    Extracellular calcium-sensing receptor
 UniProt Synonym Protein Names   
Parathyroid cell calcium-sensing receptor 1; PCaR1
 Protein Family    Extracellular calcium-sensing receptor
 UniProt Gene Name    CASR [Similar Products]
 UniProt Synonym Gene Names    GPRC2A; PCAR1; CaSR; PCaR1 [Similar Products]
 UniProt Entry Name    CASR_HUMAN
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 NCBI Summary for CASR    The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASR    CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 3

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; anatomical structure morphogenesis; ossification; metabolic process; chemosensory behavior; detection of calcium ion

Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1
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 Research Articles on CASR    1. Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CASR antibodyPathways associated with anti-CASR antibody
 Reference Product  PubMed Publications
 PTH antibody  >229 publications with CASR and PTH
 RGS4 antibody  >2 publications with CASR and RGS4
 NPSR1 antibody  >1 publications with CASR and NPSR1
 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 E-cadherin Signaling In Keratinocytes Pathway antibodies  E-cadherin Signaling In Keratinocytes Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-CASR antibodyOrgans/Tissues associated with anti-CASR antibody
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >229 publications with CASR and Hyperparathyroidism
 Hypercalcemia Antibodies  >196 publications with CASR and Hypercalcemia
 Hypocalcemia Antibodies  >118 publications with CASR and Hypocalcemia
 Kidney Diseases Antibodies  >93 publications with CASR and Kidney Diseases
 Hypoparathyroidism Antibodies  >77 publications with CASR and Hypoparathyroidism
 Hyperparathyroidism, Secondary Antibodies  >75 publications with CASR and Hyperparathyroidism, Secondary
 Hypertension Antibodies  >38 publications with CASR and Hypertension
 Renal Insufficiency Antibodies  >23 publications with CASR and Renal Insufficiency
 Brain Diseases Antibodies  >22 publications with CASR and Brain Diseases
 Hypocalciuric hypercalcemia, familial, type 1 Antibodies  >21 publications with CASR and Hypocalciuric hypercalcemia, familial, type 1
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >386 publications with CASR and Parathyroid
 Kidney Antibodies  >233 publications with CASR and Kidney
 Liver Antibodies  >33 publications with CASR and Liver
 Pancreas Antibodies  >19 publications with CASR and Pancreas
 Eye Antibodies  >1 publications with CASR and Eye
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