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anti-CHST14 antibody :: Rabbit carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714720 anti-CHST14 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14), Polyclonal Antibody

 Also Known As   

Rabbit anti-human carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 polyclonal Antibody

 Product Synonym Names    carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14; CHST14; D4ST-1; D4ST1; HD4ST; HNK1ST
 Product Gene Name   

anti-CHST14 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608429
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CHST14
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-68295 / sc-68294
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CHST14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CHST14 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for CHST14. It may not necessarily be applicable to this product.
 NCBI GI #    31565498
 NCBI GeneID    113189
 NCBI Accession #    AAH53633.1 [Other Products]
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 UniProt Secondary Accession #    Q6PJ31; Q6UXA0; Q96P94 [Other Products]
 UniProt Related Accession #    Q8NCH0 [Other Products]
 Molecular Weight    42,997 Da [Similar Products]
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 NCBI Official Full Name    Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
 NCBI Official Synonym Full Names    carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
 NCBI Official Symbol    CHST14 [Similar Products]
 NCBI Official Synonym Symbols   
ATCS; D4ST1; EDSMC1; HNK1ST
[Similar Products]
 NCBI Protein Information    carbohydrate sulfotransferase 14; dermatan 4 sulfotransferase 1
 UniProt Protein Name    Carbohydrate sulfotransferase 14
 UniProt Synonym Protein Names   
Dermatan 4-sulfotransferase 1; D4ST-1; hD4ST1
 Protein Family    Carbohydrate sulfotransferase
 UniProt Gene Name    CHST14 [Similar Products]
 UniProt Synonym Gene Names    D4ST1; D4ST-1; hD4ST1 [Similar Products]
 UniProt Entry Name    CHSTE_HUMAN
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 NCBI Summary for CHST14    This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
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 UniProt Comments for CHST14    CHST14: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. Defects in CHST14 are the cause of Ehlers-Danlos syndrome musculocontractural type (EDSMC). It is a form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement. Belongs to the sulfotransferase 2 family.

Protein type: Transferase; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.8.2.35; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: N-acetylgalactosamine 4-O-sulfotransferase activity; phosphate binding

Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; dermatan sulfate proteoglycan metabolic process; carbohydrate metabolic process; pathogenesis; carbohydrate biosynthetic process; dermatan sulfate biosynthetic process

Disease: Ehlers-danlos Syndrome, Musculocontractural Type 1
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 Research Articles on CHST14    1. We report on the detailed clinical characterization of two sisters with musculocontractural Ehlers-Danlos syndrome caused by a homozygous mutation in the CHST14 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHST14 antibodyPathways associated with anti-CHST14 antibody
 Reference Product  PubMed Publications
 DCN antibody  >1 publications with CHST14 and DCN
 DSE antibody  >1 publications with CHST14 and DSE
 Products by Pathway  Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
Diseases associated with anti-CHST14 antibodyOrgans/Tissues associated with anti-CHST14 antibody
 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >5 publications with CHST14 and Craniofacial Abnormalities
 EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE 1 Antibodies  >4 publications with CHST14 and EHLERS-DANLOS SYNDROME, MUSCULOCONTRACTURAL TYPE 1
 Heart Defects, Congenital Antibodies  >2 publications with CHST14 and Heart Defects, Congenital
 Mental Disorders Antibodies  >1 publications with CHST14 and Mental Disorders
 Eye Abnormalities Antibodies  >1 publications with CHST14 and Eye Abnormalities
 Joint Instability Antibodies  >1 publications with CHST14 and Joint Instability
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >8 publications with CHST14 and Skin
 Connective Tissue Antibodies  >5 publications with CHST14 and Connective Tissue
 Bone Antibodies  >2 publications with CHST14 and Bone
 Muscle Antibodies  >2 publications with CHST14 and Muscle
 Brain Antibodies  >2 publications with CHST14 and Brain
 Blood Antibodies  >1 publications with CHST14 and Blood
 Heart Antibodies  >1 publications with CHST14 and Heart
 Kidney Antibodies  >1 publications with CHST14 and Kidney
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