NP_060528.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cartilage acidic protein 1 isoform A
NCBI Official Synonym Full Names
cartilage acidic protein 1
NCBI Protein Information
cartilage acidic protein 1; acidic secreted protein in cartilage; chondrocyte expressed protein 68 kDa CEP-68
UniProt Protein Name
Cartilage acidic protein 1
UniProt Synonym Protein Names
68 kDa chondrocyte-expressed protein; CEP-68; ASPIC
UniProt Synonym Gene Names
UniProt Entry Name
CRAC1_HUMAN
NCBI Summary for CRTAC1
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
UniProt Comments for CRTAC1
CRTAC1: a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: proteinaceous extracellular matrix; growth cone
Molecular Function: calcium ion binding
Biological Process: olfactory bulb development; axonal fasciculation
Research Articles on CRTAC1
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Diseases associated with anti-CRTAC1 antibody
Organs/Tissues associated with anti-CRTAC1 antibody
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