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anti-Casp1 antibody :: Rabbit anti-Human caspase-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440006
Western Blot (WB)
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

caspase-1 (Casp1), Polyclonal Antibody

 Also Known As   

caspase-1 (A19) Antibody

 Product Gene Name   

anti-Casp1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P43527
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human caspase-1 precursor (also designated ICE), non cross-reactive with caspase-1 p10 or caspase-1 p20
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    Caspase-1 is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the amino terminus of Human caspase-1 precursor (also designated ICE).
 Immunogen    Synthetic peptide mapping to the amino terminal domain of human caspase-2L
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-Casp1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Casp1 antibody

   Caspases is a family of mammalian proteases that regulate many of the morphological and biochemical features of apoptosis. The currently identified caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators (1,2). Caspase-2, 8, and 9 have been identified as apoptotic initiators (3,4). Caspase-2 (also designated Nedd-2/ICH-1) can be alternatively spliced to produce two distinct Caspase-2 mRNA species. One mRNA species encodes a protein of 435 amino acids in length and the mRNA splice variant encodes a 312 amino acid protein. The larger protein, Caspase-2L, in an over expressed state, leads to programmed cell death. Conversely the over expression of Caspase-2S protein, a truncated version of Caspase-2L, has been shown to suppress cell death induced by serum deprivation (5). The executioner caspases include caspase-3, 6 and 7. Of these three proteases Caspase-3 is considered to be the essential for the chromatin margination, DNA fragmentation, and nuclear collapse during apoptosis (6). Caspase-1 (also known as ICE) is considered to be a mediator of the inflammatory response by converting the inactive precursor of interleukin-1b to the 17 kDa proinflammatory cytokine, IL-1b (7,8).
 Applications Tested/Suitable for anti-Casp1 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-Casp1 antibody    anti-Casp1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Casp1. It may not necessarily be applicable to this product.
 NCBI GI #    31542341
 NCBI GeneID    25166
 NCBI Accession #    NP_036894.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012762.2 [Other Products]
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 UniProt Primary Accession #    P43527 [Other Products]
 UniProt Related Accession #    P43527 [Other Products]
 Molecular Weight    45,576 Da [Similar Products]
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 NCBI Official Full Name    caspase-1
 NCBI Official Synonym Full Names    caspase 1
 NCBI Official Symbol    Casp1 [Similar Products]
 NCBI Official Synonym Symbols   
Ice; Il1bc
[Similar Products]
 NCBI Protein Information    caspase-1; CASP-1; IL-1 beta-converting enzyme; IL-1BC; Interleukin 1beta converting enzyme; interleukin 1, beta, convertase; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
 UniProt Protein Name    Caspase-1
 UniProt Synonym Protein Names   
Interleukin-1 beta convertase; IL-1BC
 Protein Family    Caspase
 UniProt Gene Name    Casp1 [Similar Products]
 UniProt Synonym Gene Names    Il1bc; Il1bce; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme [Similar Products]
 UniProt Entry Name    CASP1_RAT
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 NCBI Summary for Casp1    apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006]
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 UniProt Comments for Casp1    CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity)

Protein type: EC 3.4.22.36; Protease; Apoptosis
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Product References and Citations for anti-Casp1 antibody

   1. Edadah BA, Faden AI. 2000. Caspase pathways, neuronal apoptosis, and CNS injury. Jounal of Neurotauma 17(10): 811-8292. Salvesen GS, Dixit VM. 1999. Caspase activation: the induced-proximity model. Proc Natl Acad Sci USA 96(20): 10964-109673. Zhang W, He Q, Chan LL, Zhou F, El Naghy M, Thompson EB, Ansari NH. 2001. Involvment of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells. Free Radic Biol Med 30(6): 699-7064. Kruidering M, Evan GI. 2000. Caspase-8 in apoptosis: the beginning of ?the end? ? IUBMB 50(2): 85-905. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78(5): 739-7506. Slee EA, Adrain C, Martin SJ. 2001. Executioner caspase-3, -6, and ?7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276(10): 7320-73267. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Cameron P, Hillman AG, Chartrain NA, Schmidt JA. 1989. Identification of a monocyte specific pre-interleukin 1b convertase activity. Proc Natl Acad Sci USA 86(14): 5227-52318. Wilson KP, Black JA, Thompson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ. 1994. Structure and mechanism of interleukin-1b converting enzyme. Nature 370(6487): 251-252
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 Research Articles on Casp1    1. Caspase-1 activation plays an important role in the development of inflammation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Casp1 antibodyPathways associated with anti-Casp1 antibody
 Reference Product  PubMed Publications
 Il18 antibody  >558 publications with Casp1 and Il18
 Pycard antibody  >233 publications with Casp1 and Pycard
 Nlrc4 antibody  >190 publications with Casp1 and Nlrc4
 Il1b antibody  >89 publications with Casp1 and Il1b
 Nod2 antibody  >65 publications with Casp1 and Nod2
 Naip5 antibody  >35 publications with Casp1 and Naip5
 Nlrp1b antibody  >21 publications with Casp1 and Nlrp1b
 Nlrp1a antibody  >4 publications with Casp1 and Nlrp1a
 Nfkb1 antibody  >4 publications with Casp1 and Nfkb1
 Nfkb2 antibody  >2 publications with Casp1 and Nfkb2
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Organs/Tissues associated with anti-Casp1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >246 publications with Casp1 and Lung
 Spleen Antibodies  >101 publications with Casp1 and Spleen
 Eye Antibodies  >101 publications with Casp1 and Eye
 Colon Antibodies  >72 publications with Casp1 and Colon
 Adipose Tissue Antibodies  >37 publications with Casp1 and Adipose Tissue
 Small Intestine Antibodies  >22 publications with Casp1 and Small Intestine
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