AAH19089.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Cell division cycle 25 homolog C (S. pombe)
NCBI Official Synonym Full Names
cell division cycle 25C
NCBI Protein Information
M-phase inducer phosphatase 3; mitosis inducer CDC25; phosphotyrosine phosphatase; dual specificity phosphatase CDC25C; protein phosphatase 1, regulatory subunit 60
UniProt Protein Name
M-phase inducer phosphatase 3
UniProt Synonym Protein Names
Dual specificity phosphatase Cdc25C
UniProt Entry Name
MPIP3_HUMAN
NCBI Summary for CDC25C
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for CDC25C
CDC25C: a member of the MPI phosphatase family. Activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. Shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. At least four transcript variants for this gene exist. Three splice variant isoforms have been described.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus
Molecular Function: protein binding; WW domain binding; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: cell proliferation; mitosis; viral reproduction; regulation of cell cycle; cell division; regulation of mitosis; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; DNA replication
Research Articles on CDC25C
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Products associated with anti-CDC25C antibody
Pathways associated with anti-CDC25C antibody
Diseases associated with anti-CDC25C antibody
Organs/Tissues associated with anti-CDC25C antibody
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