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anti-CGNL1 antibody :: Rabbit cingulin-like 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711421 anti-CGNL1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cingulin-like 1 (CGNL1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human cingulin-like 1 polyclonal Antibody

 Product Synonym Names    cingulin-like 1; CGNL1; FLJ14957; JACOP; KIAA1749; MGC138254
 Product Gene Name   

anti-CGNL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607856
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CGNL1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-162681
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CGNL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CGNL1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CGNL1. It may not necessarily be applicable to this product.
 NCBI GI #    111600321
 NCBI GeneID    84952
 NCBI Accession #    AAI18919.1 [Other Products]
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 UniProt Secondary Accession #    Q05BZ4; Q52LR0; Q695C7; Q7Z2L3; Q96JV2; Q96MN6; Q9C0B4 [Other Products]
 UniProt Related Accession #    Q0VF96 [Other Products]
 Molecular Weight    72,186 Da [Similar Products]
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 NCBI Official Full Name    Cingulin-like 1
 NCBI Official Synonym Full Names    cingulin-like 1
 NCBI Official Symbol    CGNL1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    cingulin-like protein 1; paracingulin; junction-associated coiled-coil protein
 UniProt Protein Name    Cingulin-like protein 1
 UniProt Synonym Protein Names   
Junction-associated coiled-coil protein; Paracingulin
 Protein Family    Cingulin-like protein
 UniProt Gene Name    CGNL1 [Similar Products]
 UniProt Synonym Gene Names    JACOP; KIAA1749 [Similar Products]
 UniProt Entry Name    CGNL1_HUMAN
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 NCBI Summary for CGNL1    This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for CGNL1    CGNL1: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS). A disorder characterized by an estrogen excess due to an increased aromatase activity. A chromosomal aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region. Belongs to the cingulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: tight junction; myosin complex

Molecular Function: motor activity

Biological Process: metabolic process
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 Research Articles on CGNL1    1. ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CGNL1 antibodyOrgans/Tissues associated with anti-CGNL1 antibody
 Reference Product  PubMed Publications
 PLEKHA7 antibody  >2 publications with CGNL1 and PLEKHA7
 TIAM1 antibody  >2 publications with CGNL1 and TIAM1
 CYP19A1 antibody  >1 publications with CGNL1 and CYP19A1
 TMOD3 antibody  >1 publications with CGNL1 and TMOD3
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with CGNL1 and Kidney
 Vascular Antibodies  >1 publications with CGNL1 and Vascular
 Muscle Antibodies  >1 publications with CGNL1 and Muscle
 Heart Antibodies  >1 publications with CGNL1 and Heart
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