Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow F12 rightarrow Polyclonal F12  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Kallikrein 1 (KLK1) Recombinant Protein
 • heat shock 70kDa protein 8 (HSPA8) ELISA Kit
 • Cardiac Troponin I (cTnI) ELISA Kit
 • NFkB, p50 (NFKB1) Antibody
 • RBFOX3 Antibody
 • Kidney Injury Molecule 1 (KIM1) ELISA Kit
 • Thrombin Activatable Fibrinolysis Inhibitor (TAFI), Human Native Protein
 • Lctin like oxLDL Receptor 1 (LOX-1) ELISA Kit
 • Wnt1 Recombinant Protein
 • Aldehyde oxidase 2 (AAO2), partial Recombinant Protein
 • ACAP3 Antibody
 • ATP5O Recombinant Protein
 • erythropoietin (EPO) ELISA Kit
 • D-Aspartate (BSA) conjugate Antigen
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-F12 antibody :: Rabbit coagulation factor XII (Hageman factor) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710592 anti-F12 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

coagulation factor XII (Hageman factor) (F12), Polyclonal Antibody

 Also Known As   

Rabbit anti-human coagulation factor XII (Hageman factor) polyclonal Antibody

 Product Synonym Names    coagulation factor XII (Hageman factor); F12; HAE3; HAEX; HAF
 Product Gene Name   

anti-F12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    610619
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Immunogen    Human F12
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66752
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-F12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-F12 antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for F12. It may not necessarily be applicable to this product.
 NCBI GI #    145275213
 NCBI GeneID    2161
 NCBI Accession #    NP_000496.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000505.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    P78339 [Other Products]
 UniProt Related Accession #    P00748 [Other Products]
 Molecular Weight    67,792 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    coagulation factor XII
 NCBI Official Synonym Full Names    coagulation factor XII (Hageman factor)
 NCBI Official Symbol    F12 [Similar Products]
 NCBI Official Synonym Symbols   
HAF; HAE3; HAEX
[Similar Products]
 NCBI Protein Information    coagulation factor XII; Hageman factor; beta-factor XIIa part 1; beta-factor XIIa part 2; coagulation factor XIIa heavy chain; coagulation factor XIIa light chain
 UniProt Protein Name    Coagulation factor XII
 UniProt Synonym Protein Names   
Hageman factor; HAF
 Protein Family    Coagulation factor
 UniProt Gene Name    F12 [Similar Products]
 UniProt Synonym Gene Names    HAF [Similar Products]
 UniProt Entry Name    FA12_HUMAN
Section Bar
 NCBI Summary for F12    This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for F12    F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.38; Secreted; Protease; Secreted, signal peptide; Chaperone

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; misfolded protein binding

Biological Process: response to misfolded protein; positive regulation of blood coagulation; proteolysis; protein autoprocessing; fibrinolysis; plasma kallikrein-kinin cascade; innate immune response; positive regulation of fibrinolysis; protein processing; zymogen activation; blood coagulation; blood coagulation, intrinsic pathway; Factor XII activation

Disease: Angioedema, Hereditary, Type Iii; Factor Xii Deficiency
Table BarTOPTable Bar
 Research Articles on F12    1. FVIIa- and FXIIa-triggered coagulation pathways have distinct but complementary roles in atherothrombus formation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-F12 antibodyPathways associated with anti-F12 antibody
 Reference Product  PubMed Publications
 GP1BA antibody  >5 publications with F12 and GP1BA
 SERPING1 antibody  >5 publications with F12 and SERPING1
 KLKB1 antibody  >4 publications with F12 and KLKB1
 KNG1 antibody  >3 publications with F12 and KNG1
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
Diseases associated with anti-F12 antibodyOrgans/Tissues associated with anti-F12 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >61 publications with F12 and Cardiovascular Diseases
 Carcinoma Antibodies  >55 publications with F12 and Carcinoma
 Nervous System Diseases Antibodies  >53 publications with F12 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >28 publications with F12 and Neoplasms, Experimental
 Thrombosis Antibodies  >26 publications with F12 and Thrombosis
 Necrosis Antibodies  >24 publications with F12 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >20 publications with F12 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >19 publications with F12 and Liver Diseases
 Fibrosis Antibodies  >19 publications with F12 and Fibrosis
 Liver Neoplasms Antibodies  >18 publications with F12 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >100 publications with F12 and Brain
 Embryonic Tissue Antibodies  >86 publications with F12 and Embryonic Tissue
 Kidney Antibodies  >69 publications with F12 and Kidney
 Liver Antibodies  >66 publications with F12 and Liver
 Connective Tissue Antibodies  >51 publications with F12 and Connective Tissue
 Testis Antibodies  >44 publications with F12 and Testis
 Lung Antibodies  >42 publications with F12 and Lung
 Intestine Antibodies  >20 publications with F12 and Intestine
 Uterus Antibodies  >19 publications with F12 and Uterus
 Prostate Antibodies  >13 publications with F12 and Prostate
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions