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anti-CCDC22 antibody :: Rabbit coiled-coil domain containing 22 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719208 anti-CCDC22 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

coiled-coil domain containing 22 (CCDC22), Polyclonal Antibody

 Also Known As   

Rabbit anti-human coiled-coil domain containing 22 polyclonal Antibody

 Product Synonym Names    coiled-coil domain containing 22; CCDC22; CXorf37; JM1
 Product Gene Name   

anti-CCDC22 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300859
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CCDC22
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CCDC22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CCDC22 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for CCDC22. It may not necessarily be applicable to this product.
 NCBI GI #    15079717
 NCBI GeneID    28952
 NCBI Accession #    AAH11675.1 [Other Products]
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 UniProt Secondary Accession #    A8K7G1 [Other Products]
 UniProt Related Accession #    O60826 [Other Products]
 Molecular Weight    70,756 Da [Similar Products]
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 NCBI Official Full Name    Coiled-coil domain containing 22
 NCBI Official Synonym Full Names    coiled-coil domain containing 22
 NCBI Official Symbol    CCDC22 [Similar Products]
 NCBI Official Synonym Symbols   
JM1; CXorf37
[Similar Products]
 NCBI Protein Information    coiled-coil domain-containing protein 22
 UniProt Protein Name    Coiled-coil domain-containing protein 22
 Protein Family    Coiled-coil domain-containing protein
 UniProt Gene Name    CCDC22 [Similar Products]
 UniProt Synonym Gene Names    CXorf37 [Similar Products]
 UniProt Entry Name    CCD22_HUMAN
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 NCBI Summary for CCDC22    This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
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 UniProt Comments for CCDC22    CCDC22: May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X- linked syndromic mental retardation, and carrying variant Ala-17. In addition to intellectual disability, affected individuals have cardiac and skeletal abnormalities. Belongs to the CCDC22 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: endosome

Molecular Function: protein binding

Biological Process: Golgi to plasma membrane transport; protein transport; cytoplasmic sequestering of NF-kappaB; positive regulation of I-kappaB kinase/NF-kappaB cascade; cellular copper ion homeostasis; negative regulation of I-kappaB kinase/NF-kappaB cascade
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 Research Articles on CCDC22    1. CCDC22 participates in NF-kappaB activation and its deficiency leads to decreased IkappaB turnover
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CCDC22 antibodyOrgans/Tissues associated with anti-CCDC22 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with CCDC22 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with CCDC22 and Abnormalities, Multiple
 Craniofacial Abnormalities Antibodies  >1 publications with CCDC22 and Craniofacial Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with CCDC22 and Heart Defects, Congenital
 Inflammation Antibodies  >1 publications with CCDC22 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with CCDC22 and Lung
 Blood Antibodies  >1 publications with CCDC22 and Blood
 Brain Antibodies  >1 publications with CCDC22 and Brain
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