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anti-COL1A2 antibody :: Rabbit collagen, type I, alpha 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713629 anti-COL1A2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

collagen, type I, alpha 2 (COL1A2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human collagen, type I, alpha 2 polyclonal Antibody

 Product Synonym Names    collagen; type I; alpha 2; COL1A2; OI4
 Product Gene Name   

anti-COL1A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    259420
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human COL1A2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8787 / sc-8786 / sc-8785 / sc-28655
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COL1A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COL1A2 purchase    As one of the most abundant proteins, generating polyclonal antibodies to collagen type I alpha 2 is a snap. But getting a highly specific, economical and validated Col1A2 antibody requires MyBiosource's know how and technical savvy. Our rabbit, pan species including reactivity human, mouse, anti Col1A2 only recognizes type alpha 2 chain not related type IX. We have other primary antibodies for those in our product catalog unit. This rabbit polyclonal against Col1A2 collagen alpha is assay ready. Chose, IHC immunohistochemistry - cells or paraffin embedded tissue- western blot or develop your own ELISA kits for analysis as found in previous publications.Available in 2 economical sizes and priced to move, you can stock up for a CELL day party of western blot ELISA experiments. Add in more products rabbit polyclonalreactivity tp say collagen type IX and watch the fun. Join in today and have your own antibody rabbit day.
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 Applications Tested/Suitable for anti-COL1A2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for COL1A2. It may not necessarily be applicable to this product.
 NCBI GI #    45708783
 NCBI GeneID    1278
 NCBI Accession #    AAH42586.1 [Other Products]
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 UniProt Secondary Accession #    P02464; Q13897; Q13997; Q13998; Q14038; Q14057; Q15177; Q15947; Q16480; Q16511; Q7Z5S6 [Other Products]
 UniProt Related Accession #    P08123 [Other Products]
 Molecular Weight    129,314 Da [Similar Products]
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 NCBI Official Full Name    Collagen, type I, alpha 2
 NCBI Official Synonym Full Names    collagen, type I, alpha 2
 NCBI Official Symbol    COL1A2 [Similar Products]
 NCBI Official Synonym Symbols   
OI4
[Similar Products]
 NCBI Protein Information    collagen alpha-2(I) chain; collagen alpha-2(I) chain; type I procollagen; alpha 2(I)-collagen; alpha-2 type I collagen; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain
 UniProt Protein Name    Collagen alpha-2(I) chain
 UniProt Synonym Protein Names   
Alpha-2 type I collagen
 Protein Family    Collagen
 UniProt Gene Name    COL1A2 [Similar Products]
 UniProt Entry Name    CO1A2_HUMAN
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 NCBI Summary for COL1A2    This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
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 UniProt Comments for COL1A2    COL1A2: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A2 are the cause of Ehlers-Danlos syndrome type 7B (EDS7B). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7B is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A2 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita (OIC) or lethal perinatal. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A2 are the cause of Ehlers-Danlos syndrome autosomal recessive cardiac valvular form (EDSCV). A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic insufficiency. Defects in COL1A2 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A2 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1. Belongs to the fibrillar collagen family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen type I

Molecular Function: protein binding, bridging; identical protein binding; protein binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding; SMAD binding

Biological Process: receptor-mediated endocytosis; blood vessel development; platelet activation; extracellular matrix organization and biogenesis; collagen fibril organization; skin morphogenesis; Rho protein signal transduction; odontogenesis; collagen catabolic process; extracellular matrix disassembly; regulation of blood pressure; transforming growth factor beta receptor signaling pathway; blood coagulation; skeletal development; leukocyte migration

Disease: Ehlers-danlos Syndrome, Type Vii, Autosomal Dominant; Osteogenesis Imperfecta, Type Ii; Ehlers-danlos Syndrome, Autosomal Recessive, Cardiac Valvular Form; Osteogenesis Imperfecta, Type Iii; Osteoporosis; Osteogenesis Imperfecta, Type Iv
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 Research Articles on COL1A2    1. The COL1A2 gene is associated with intracranial aneurysms in a subset of the German population, but it is not responsible for the majority of aneurysms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-COL1A2 antibodyDiseases associated with anti-COL1A2 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >186 publications with COL1A2 and Fibrosis
 Cardiovascular Diseases Antibodies  >94 publications with COL1A2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >42 publications with COL1A2 and Liver Diseases
 Inflammation Antibodies  >39 publications with COL1A2 and Inflammation
 Osteoporosis Antibodies  >36 publications with COL1A2 and Osteoporosis
 Heart Diseases Antibodies  >35 publications with COL1A2 and Heart Diseases
 Necrosis Antibodies  >32 publications with COL1A2 and Necrosis
 Liver Cirrhosis Antibodies  >31 publications with COL1A2 and Liver Cirrhosis
 Kidney Diseases Antibodies  >23 publications with COL1A2 and Kidney Diseases
 Carcinoma Antibodies  >22 publications with COL1A2 and Carcinoma
Organs/Tissues associated with anti-COL1A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >274 publications with COL1A2 and Bone
 Connective Tissue Antibodies  >197 publications with COL1A2 and Connective Tissue
 Skin Antibodies  >192 publications with COL1A2 and Skin
 Muscle Antibodies  >79 publications with COL1A2 and Muscle
 Blood Antibodies  >74 publications with COL1A2 and Blood
 Liver Antibodies  >72 publications with COL1A2 and Liver
 Embryonic Tissue Antibodies  >50 publications with COL1A2 and Embryonic Tissue
 Vascular Antibodies  >48 publications with COL1A2 and Vascular
 Heart Antibodies  >43 publications with COL1A2 and Heart
 Lung Antibodies  >42 publications with COL1A2 and Lung
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