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anti-COLEC11 antibody :: Rabbit collectin sub-family member 11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713210 anti-COLEC11 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

collectin sub-family member 11 (COLEC11), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human collectin sub-family member 11 polyclonal Antibody

 Product Synonym Names    collectin sub-family member 11; COLEC11; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1; DKFZp686N1868; MGC3279
 Product Gene Name   

anti-COLEC11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS713210 COA    COA PDF
 MBS713210 Technical Datasheet    Technical Datasheet PDF
 OMIM    612502
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Zebrafish
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human COLEC11
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-242495 / sc-242497
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COLEC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COLEC11 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for COLEC11. It may not necessarily be applicable to this product.
 NCBI GI #    31455215
 NCBI GeneID    78989
 NCBI Accession #    AAH09951.1 [Other Products]
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 UniProt Secondary Accession #    Q5CZ85; A1IGE4; A1IGE5; A1IGE6; A7VJJ2; A7VJJ3; A7VJJ4; A7VJJ5; B2R9M5; B4E1G0; J3KQY9 [Other Products]
 UniProt Related Accession #    Q9BWP8 [Other Products]
 Molecular Weight    30,200 Da [Similar Products]
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 NCBI Official Full Name    Collectin sub-family member 11
 NCBI Official Synonym Full Names    collectin sub-family member 11
 NCBI Official Symbol    COLEC11 [Similar Products]
 NCBI Official Synonym Symbols   
3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb
[Similar Products]
 NCBI Protein Information    collectin-11; Collectin K1; collectin kidney protein 1
 UniProt Protein Name    Collectin-11
 UniProt Synonym Protein Names   
Collectin kidney protein 1; CL-K1
 Protein Family    Collectin
 UniProt Gene Name    COLEC11 [Similar Products]
 UniProt Synonym Gene Names    CL-K1 [Similar Products]
 UniProt Entry Name    COL11_HUMAN
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 NCBI Summary for COLEC11    This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for COLEC11    COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: collagen; extracellular region

Molecular Function: mannose binding

Biological Process: receptor-mediated endocytosis; multicellular organismal development; developmental process

Disease: 3mc Syndrome 2
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 Research Articles on COLEC11    1. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2, the complex deposited C4b.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-COLEC11 antibodyDiseases associated with anti-COLEC11 antibody
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Scavenging By Class A Receptors Pathway antibodies  Scavenging By Class A Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Learning Disorders Antibodies  >1 publications with COLEC11 and Learning Disorders
 Disease Models, Animal Antibodies  >1 publications with COLEC11 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with COLEC11 and Inflammation
 Liver Diseases Antibodies  >1 publications with COLEC11 and Liver Diseases
 Craniofacial Abnormalities Antibodies  >1 publications with COLEC11 and Craniofacial Abnormalities
Organs/Tissues associated with anti-COLEC11 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with COLEC11 and Kidney
 Liver Antibodies  >2 publications with COLEC11 and Liver
 Heart Antibodies  >1 publications with COLEC11 and Heart
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