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anti-CDSN antibody :: Rabbit anti-Human, Mouse corneodesmosin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713765 anti-CDSN antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

corneodesmosin (CDSN), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human corneodesmosin polyclonal Antibody

 Product Synonym Names    corneodesmosin; CDSN; D6S586E; HTSS; S
 Product Gene Name   

anti-CDSN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602593
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CDSN
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49616 / sc-49620 / sc-49621
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CDSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CDSN purchase    Skin is one of our most important, yet overlooked organs. It provides protection from infection and damage from UV radiation. Defects in important proteins, such as corneodesmosin, result in disfiguring or debilitating chronic conditions. Much of the human research data collected to date has utilized CDSN antibodies to quantitate CDSN gene protein expression. MyBiosource provides a top of line anti corneodesmosin antibody. This rabbit polyclonal antibody is ideal as a stand alone species human specific primary antibody for IHC or Western blot using dylight 174 - ALEXA 174 fluor secondary antibodies. Paired with our quality mouse monoclonal CDSN antibody, cellular biochemical assays such as sensitive ELISA kits are possible. We offer both anti mouse IgG2a heavy chain antibodies secondary antibodies and anti rabbit polyclonal species products for easy assay designs specific for cell or tissue needs. Our catalogue of primary antibodies is extensive and includes human mouse rat product reagents.
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 Applications Tested/Suitable for anti-CDSN antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for CDSN. It may not necessarily be applicable to this product.
 NCBI GI #    67782356
 NCBI GeneID    1041
 NCBI Accession #    NP_001255.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001264.4 [Other Products]
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 UniProt Secondary Accession #    O43509; Q5SQ85; Q5STD2; Q7LA70; Q7LA71; Q86Z04; Q8IZU4; Q8IZU5; Q8IZU6; B0S7V2; B0UYZ7 [Other Products]
 UniProt Related Accession #    Q15517 [Other Products]
 Molecular Weight    51,522 Da [Similar Products]
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 NCBI Official Full Name    corneodesmosin
 NCBI Official Synonym Full Names    corneodesmosin
 NCBI Official Symbol    CDSN [Similar Products]
 NCBI Official Synonym Symbols   
S; PSS; HTSS; HTSS1; HYPT2; D6S586E
[Similar Products]
 NCBI Protein Information    corneodesmosin; differentiated keratinocyte S protein
 UniProt Protein Name    Corneodesmosin
 UniProt Synonym Protein Names   
S protein
 Protein Family    Corneodesmosin
 UniProt Gene Name    CDSN [Similar Products]
 UniProt Entry Name    CDSN_HUMAN
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 NCBI Summary for CDSN    This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDSN    CDSN: Important for the epidermal barrier integrity. Defects in CDSN are the cause of hypotrichosis type 2 (HYPT2). A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Defects in CDSN are a cause of peeling skin syndrome (PSS); also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. A genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels. CDNS mutations are responsible for generalized, inflammatory peeling skin syndrome type B (PubMed:20691404).

Protein type: Secreted, signal peptide; Cell adhesion; Secreted

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: desmosome; cornified envelope; intercellular junction

Molecular Function: protein homodimerization activity

Biological Process: keratinocyte differentiation; epidermis development; cell-cell adhesion; skin morphogenesis; cell adhesion

Disease: Peeling Skin Syndrome 1; Hypotrichosis 2
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 Research Articles on CDSN    1. PSORS1C1/CDSN gene may play a pathogenic role in ankylosing spondylitis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CDSN antibodyOrgans/Tissues associated with anti-CDSN antibody
 Disease Name  Pubmed Publications
 HYPOTRICHOSIS 2 Antibodies  >3 publications with CDSN and HYPOTRICHOSIS 2
 Inflammation Antibodies  >2 publications with CDSN and Inflammation
 Colorectal Neoplasms Antibodies  >1 publications with CDSN and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >1 publications with CDSN and Colonic Neoplasms
 Gastrointestinal Diseases Antibodies  >1 publications with CDSN and Gastrointestinal Diseases
 Necrosis Antibodies  >1 publications with CDSN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >61 publications with CDSN and Skin
 Heart Antibodies  >2 publications with CDSN and Heart
 Kidney Antibodies  >1 publications with CDSN and Kidney
 Thymus Antibodies  >1 publications with CDSN and Thymus
 Placenta Antibodies  >1 publications with CDSN and Placenta
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