Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CYLD rightarrow Polyclonal CYLD  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Cytochrome P450 1A2 (CYP1A2) ELISA Kit
 • 3-mercaptopyruvate sulfurtransferase (MPST) Recombinant Protein
 • ESAT-6-like protein EsxH Recombinant Protein
 • beta Amyloid Antibody
 • BAFFR ELISA Kit
 • CD9 antigen (CD9) ELISA Kit
 • Arylalkylamine N-Acetyltransferase (AA-NAT) ELISA Kit
 • AAV VP1 + VP2 + VP3 (AAV VP1 - VP2 - VP3) Antibody
 • MAPK8 Antibody
 • Erythropoietin (EPO) Recombinant Protein
 • HTATIP Antibody
 • translocation associated membrane protein 2 (TRAM2) ELISA Kit
 • PLTP Antibody
 • 1-acyl-sn-glycerol-3-phosph ate acyltransferase beta (AGPAT2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CYLD antibody :: Rabbit cylindromatosis Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716699 anti-CYLD antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cylindromatosis (CYLD), Polyclonal Antibody

 Also Known As   

Rabbit anti-human cylindromatosis (turban tumor syndrome) polyclonal Antibody

 Product Synonym Names    cylindromatosis (turban tumor syndrome); CYLD; CDMT; CYLD1; CYLDI; EAC; FLJ20180; FLJ31664; FLJ78684; HSPC057; KIAA0849; MFT; MFT1; SBS; TEM; USPL2
 Product Gene Name   

anti-CYLD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 605041
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Immunogen    Human CYLD
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21286 / sc-25779
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CYLD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-CYLD antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CYLD. It may not necessarily be applicable to this product.
 NCBI GI #    15214434
 NCBI GeneID    1540
 NCBI Accession #    AAH12342.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    O94934; Q7L3N6; Q96EH0; Q9NZX9 [Other Products]
 UniProt Related Accession #    Q9NQC7 [Other Products]
 Molecular Weight    107,044 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    Cylindromatosis (turban tumor syndrome)
 NCBI Official Synonym Full Names    cylindromatosis (turban tumor syndrome)
 NCBI Official Symbol    CYLD [Similar Products]
 NCBI Official Synonym Symbols   
EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; deubiquitinating enzyme CYLD; ubiquitin thiolesterase CYLD; ubiquitin specific peptidase like 2; ubiquitin-specific-processing protease CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase CYLD
 UniProt Synonym Protein Names   
Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    CYLD [Similar Products]
 UniProt Synonym Gene Names    CYLD1; KIAA0849 [Similar Products]
 UniProt Entry Name    CYLD_HUMAN
Section Bar
 NCBI Summary for CYLD    This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CYLD    CYLD: Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Interacts (via CAP-Gly domain) with IKBKG/NEMO (via proline-rich C-terminal region). Interacts with TRAF2 and TRIP. Interacts with PLK1, DVL1, DVL3, MAVS, TBK1, IKKE and DDX58. Interacts (via CAP-Gly domain) with microtubules. Interacts with HDAC6 and BCL3. Interacts with SQSTM1 and MAP3K7. Identified in a complex with TRAF6 and SQSTM1. Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. Inhibited by phosphorylation at serine residues. Belongs to the peptidase C67 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Ubiquitin-specific protease; EC 3.4.19.12; Tumor suppressor; Protease

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: nucleoplasm; centrosome; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasmic microtubule; spindle; midbody; cytosol

Molecular Function: protein binding; structural constituent of ribosome; zinc ion binding; ubiquitin-specific protease activity; protein kinase binding

Biological Process: ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; inhibition of NF-kappaB transcription factor; regulation of mitotic cell cycle; innate immune response; negative regulation of NF-kappaB import into nucleus; cell cycle; negative regulation of T cell differentiation; negative regulation of interferon type I production

Disease: Brooke-spiegler Syndrome; Cylindromatosis, Familial; Trichoepithelioma, Multiple Familial, 1
Table BarTOPTable Bar
 Research Articles on CYLD    1. The data provide mechanistic insights into the actions of CYLD in the regulation of microtubule dynamics and cell migration.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CYLD antibodyPathways associated with anti-CYLD antibody
 Reference Product  PubMed Publications
 TRAF2 antibody  >26 publications with CYLD and TRAF2
 TRAF6 antibody  >25 publications with CYLD and TRAF6
 DDX58 antibody  >6 publications with CYLD and DDX58
 IKBKG antibody  >6 publications with CYLD and IKBKG
 RIPK1 antibody  >5 publications with CYLD and RIPK1
 SQSTM1 antibody  >4 publications with CYLD and SQSTM1
 OPTN antibody  >1 publications with CYLD and OPTN
 TNFRSF1A antibody  >1 publications with CYLD and TNFRSF1A
 TRAIP antibody  >1 publications with CYLD and TRAIP
 Products by Pathway  Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD1/2 Signaling Pathway antibodies  NOD1/2 Signaling Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
Diseases associated with anti-CYLD antibodyOrgans/Tissues associated with anti-CYLD antibody
 Disease Name  Pubmed Publications
 Familial cylindromatosis Antibodies  >60 publications with CYLD and Familial cylindromatosis
 Inflammation Antibodies  >59 publications with CYLD and Inflammation
 Adenocarcinoma Antibodies  >56 publications with CYLD and Adenocarcinoma
 Necrosis Antibodies  >54 publications with CYLD and Necrosis
 Cell Transformation, Neoplastic Antibodies  >15 publications with CYLD and Cell Transformation, Neoplastic
 Gastrointestinal Diseases Antibodies  >14 publications with CYLD and Gastrointestinal Diseases
 Liver Diseases Antibodies  >10 publications with CYLD and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >10 publications with CYLD and Carcinoma, Squamous Cell
 Trichoepithelioma multiple familial Antibodies  >9 publications with CYLD and Trichoepithelioma multiple familial
 Cardiovascular Diseases Antibodies  >9 publications with CYLD and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >103 publications with CYLD and Skin
 Blood Antibodies  >45 publications with CYLD and Blood
 Lung Antibodies  >17 publications with CYLD and Lung
 Liver Antibodies  >13 publications with CYLD and Liver
 Bone Antibodies  >10 publications with CYLD and Bone
 Bone Marrow Antibodies  >6 publications with CYLD and Bone Marrow
 Vascular Antibodies  >6 publications with CYLD and Vascular
 Kidney Antibodies  >6 publications with CYLD and Kidney
 Ear Antibodies  >5 publications with CYLD and Ear
 Brain Antibodies  >5 publications with CYLD and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions