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anti-DOCK8 antibody :: Rabbit dedicator of cytokinesis 8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716668 anti-DOCK8 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

dedicator of cytokinesis 8 (DOCK8), Polyclonal Antibody

 Also Known As   

Rabbit anti-human dedicator of cytokinesis 8 polyclonal Antibody

 Product Synonym Names    dedicator of cytokinesis 8; DOCK8; FLJ00026; FLJ00152; FLJ00346; MRD2; ZIR8
 Product Gene Name   

anti-DOCK8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614113
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DOCK8
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104911 / sc-292124
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DOCK8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DOCK8 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DOCK8. It may not necessarily be applicable to this product.
 NCBI GI #    302129691
 NCBI GeneID    81704
 NCBI Accession #    NP_001180465.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193536.1 [Other Products]
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 UniProt Secondary Accession #    Q3MV16; Q5JPJ1; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09 [Other Products]
 UniProt Related Accession #    Q8NF50 [Other Products]
 Molecular Weight    227,477 Da [Similar Products]
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 NCBI Official Full Name    dedicator of cytokinesis protein 8 isoform 3
 NCBI Official Synonym Full Names    dedicator of cytokinesis 8
 NCBI Official Symbol    DOCK8 [Similar Products]
 NCBI Official Synonym Symbols   
MRD2; ZIR8; HEL-205
[Similar Products]
 NCBI Protein Information    dedicator of cytokinesis protein 8; 1200017A24Rik; epididymis luminal protein 205
 UniProt Protein Name    Dedicator of cytokinesis protein 8
 Protein Family    Dedicator of cytokinesis protein
 UniProt Gene Name    DOCK8 [Similar Products]
 UniProt Entry Name    DOCK8_HUMAN
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 NCBI Summary for DOCK8    This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
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 UniProt Comments for DOCK8    DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, misc.

Chromosomal Location of Human Ortholog: 9p24.3

Cellular Component: membrane; leading edge; cytosol

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity

Biological Process: formation of immunological synapse; small GTPase mediated signal transduction; blood coagulation; positive regulation of GTPase activity

Disease: Mental Retardation, Autosomal Dominant 2; Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive
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 Research Articles on DOCK8    1. Two novel large deletions, del1-14 exons and del8-18 exons, of DOCK8 have been identified in two siblings with the adaptive immune deficiencies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-DOCK8 antibodyDiseases associated with anti-DOCK8 antibody
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Job Syndrome Antibodies  >30 publications with DOCK8 and Job Syndrome
 Nervous System Diseases Antibodies  >8 publications with DOCK8 and Nervous System Diseases
 Disease Models, Animal Antibodies  >6 publications with DOCK8 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with DOCK8 and Inflammation
 Brain Diseases Antibodies  >4 publications with DOCK8 and Brain Diseases
 Congenital Abnormalities Antibodies  >3 publications with DOCK8 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >3 publications with DOCK8 and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with DOCK8 and Liver Diseases
 Abnormalities, Multiple Antibodies  >2 publications with DOCK8 and Abnormalities, Multiple
 Intellectual Disability Antibodies  >2 publications with DOCK8 and Intellectual Disability
Organs/Tissues associated with anti-DOCK8 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with DOCK8 and Blood
 Skin Antibodies  >16 publications with DOCK8 and Skin
 Bone Marrow Antibodies  >8 publications with DOCK8 and Bone Marrow
 Lung Antibodies  >6 publications with DOCK8 and Lung
 Connective Tissue Antibodies  >5 publications with DOCK8 and Connective Tissue
 Lymph Node Antibodies  >5 publications with DOCK8 and Lymph Node
 Vascular Antibodies  >4 publications with DOCK8 and Vascular
 Lymph Antibodies  >3 publications with DOCK8 and Lymph
 Thymus Antibodies  >2 publications with DOCK8 and Thymus
 Brain Antibodies  >2 publications with DOCK8 and Brain
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