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anti-DNASE2 antibody :: Rabbit deoxyribonuclease II, lysosomal Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714026 anti-DNASE2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

deoxyribonuclease II, lysosomal (DNASE2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human deoxyribonuclease II, lysosomal polyclonal Antibody

 Product Synonym Names    deoxyribonuclease II; lysosomal; DNASE2; DNASE2A; DNL; DNL2
 Product Gene Name   

anti-DNASE2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126350
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DNASE2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19271 / sc-19272
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DNASE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DNASE2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DNASE2. It may not necessarily be applicable to this product.
 NCBI GI #    40807211
 NCBI GeneID    1777
 NCBI Accession #    AAH65209.1 [Other Products]
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 UniProt Secondary Accession #    O43910; B2RD06; B7Z4K6 [Other Products]
 UniProt Related Accession #    O00115 [Other Products]
 Molecular Weight    33,615 Da [Similar Products]
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 NCBI Official Full Name    Deoxyribonuclease II, lysosomal
 NCBI Official Synonym Full Names    deoxyribonuclease II, lysosomal
 NCBI Official Symbol    DNASE2 [Similar Products]
 NCBI Official Synonym Symbols   
DNL; DNL2; DNASE2A
[Similar Products]
 NCBI Protein Information    deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha
 UniProt Protein Name    Deoxyribonuclease-2-alpha
 UniProt Synonym Protein Names   
Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2
 Protein Family    Deoxyribonuclease
 UniProt Gene Name    DNASE2 [Similar Products]
 UniProt Synonym Gene Names    DNASE2A; DNL2; DNase II alpha [Similar Products]
 UniProt Entry Name    DNS2A_HUMAN
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 NCBI Summary for DNASE2    This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DNASE2    DNASE2: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family.

Protein type: Deoxyribonuclease; EC 3.1.22.1

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: lysosome; intracellular

Molecular Function: deoxyribonuclease II activity; DNA binding

Biological Process: erythrocyte differentiation; DNA fragmentation during apoptosis; DNA metabolic process
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 Research Articles on DNASE2    1. 15 nonsynonymous human DNase II SNPs were genotyped in three ethnic groups including 16 different populations using the PCR-restriction fragment length polymorphism technique.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DNASE2 antibodyPathways associated with anti-DNASE2 antibody
 Reference Product  PubMed Publications
 DNASE1 antibody  >3 publications with DNASE2 and DNASE1
 DFFB antibody  >3 publications with DNASE2 and DFFB
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with anti-DNASE2 antibodyOrgans/Tissues associated with anti-DNASE2 antibody
 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >4 publications with DNASE2 and Musculoskeletal Diseases
 Inflammation Antibodies  >2 publications with DNASE2 and Inflammation
 Fibrosis Antibodies  >1 publications with DNASE2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with DNASE2 and Blood
 Thyroid Antibodies  >1 publications with DNASE2 and Thyroid
 Liver Antibodies  >1 publications with DNASE2 and Liver
 Ascites Antibodies  >1 publications with DNASE2 and Ascites
 Ovary Antibodies  >1 publications with DNASE2 and Ovary
 Lung Antibodies  >1 publications with DNASE2 and Lung
 Kidney Antibodies  >1 publications with DNASE2 and Kidney
 Brain Antibodies  >1 publications with DNASE2 and Brain
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