AAH65209.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Deoxyribonuclease II, lysosomal
NCBI Official Synonym Full Names
deoxyribonuclease II, lysosomal
NCBI Protein Information
deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha
UniProt Protein Name
Deoxyribonuclease-2-alpha
UniProt Synonym Protein Names
Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2
UniProt Synonym Gene Names
UniProt Entry Name
DNS2A_HUMAN
NCBI Summary for DNASE2
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
UniProt Comments for DNASE2
DNASE2: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family.
Protein type: Deoxyribonuclease; EC 3.1.22.1
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: lysosome; intracellular
Molecular Function: deoxyribonuclease II activity; DNA binding
Biological Process: erythrocyte differentiation; DNA fragmentation during apoptosis; DNA metabolic process
Research Articles on DNASE2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-DNASE2 antibody
Pathways associated with anti-DNASE2 antibody
Diseases associated with anti-DNASE2 antibody
Organs/Tissues associated with anti-DNASE2 antibody
|