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anti-DICER1 antibody :: Rabbit dicer 1, ribonuclease type III Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712147 anti-DICER1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

dicer 1, ribonuclease type III (DICER1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human dicer 1, ribonuclease type III polyclonal Antibody

 Product Synonym Names    dicer 1; ribonuclease type III; DICER1; DCR1; Dicer; HERNA; KIAA0928
 Product Gene Name   

anti-DICER1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606241
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DICER1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-25117 / sc-34602 / sc-34601 / sc-34600 / sc-30226
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DICER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DICER1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DICER1. It may not necessarily be applicable to this product.
 NCBI GI #    152012889
 NCBI GeneID    23405
 NCBI Accession #    AAI50288.1 [Other Products]
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 UniProt Secondary Accession #    O95943; Q9UQ02; A7E2D3; B3KRG4; E0AD28 [Other Products]
 UniProt Related Accession #    Q9UPY3 [Other Products]
 Molecular Weight    92,726 Da [Similar Products]
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 NCBI Official Full Name    Dicer 1, ribonuclease type III
 NCBI Official Synonym Full Names    dicer 1, ribonuclease type III
 NCBI Official Symbol    DICER1 [Similar Products]
 NCBI Official Synonym Symbols   
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e
[Similar Products]
 NCBI Protein Information    endoribonuclease Dicer; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; multinodular goitre 1; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease
 UniProt Protein Name    Endoribonuclease Dicer
 UniProt Synonym Protein Names   
Helicase with RNase motif; Helicase MOI
 Protein Family    Endoribonuclease
 UniProt Gene Name    DICER1 [Similar Products]
 UniProt Synonym Gene Names    DICER; HERNA; KIAA0928; Helicase MOI [Similar Products]
 UniProt Entry Name    DICER_HUMAN
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 NCBI Summary for DICER1    This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
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 UniProt Comments for DICER1    DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: Ribonuclease; EC 3.1.26.3; RNA-binding; RNA processing; Helicase; Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: growth cone; axon; cytoplasm; dendrite; ER-Golgi intermediate compartment; nucleus; cytosol

Molecular Function: endoribonuclease activity; protein binding; ribonuclease III activity; miRNA binding; metal ion binding; double-stranded RNA binding; deoxyribonuclease I activity; helicase activity; ATP binding

Biological Process: zygote asymmetric cell division; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; angiogenesis; DNA fragmentation during apoptosis; regulation of viral genome replication; defense response to virus; spleen development; positive regulation of myelination; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; inner ear receptor cell development; multicellular organism growth; RNA interference, targeting of mRNA for destruction; mRNA stabilization; stem cell maintenance; RNA interference, conversion of ds siRNA to ss siRNA; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; cartilage development; nerve development; gene expression; cerebral cortex development; reproductive structure development; RNA interference, production of siRNA; neurite morphogenesis; myoblast cell differentiation involved in skeletal muscle regeneration; lung development

Disease: Pleuropulmonary Blastoma; Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Rhabdomyosarcoma, Embryonal, 2
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 Research Articles on DICER1    1. Importance of a weak G-U or U-G base pair at the top of the shRNA hairpin stem to hinder Dicer recognition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DICER1 antibodyPathways associated with anti-DICER1 antibody
 Reference Product  PubMed Publications
 EIF2C2 antibody  >47 publications with DICER1 and EIF2C2
 EIF2C1 antibody  >14 publications with DICER1 and EIF2C1
 XPO5 antibody  >12 publications with DICER1 and XPO5
 PRKRA antibody  >8 publications with DICER1 and PRKRA
 TARBP2 antibody  >8 publications with DICER1 and TARBP2
 EIF2C3 antibody  >5 publications with DICER1 and EIF2C3
 FXR1 antibody  >3 publications with DICER1 and FXR1
 PIWIL1 antibody  >2 publications with DICER1 and PIWIL1
 EIF2C4 antibody  >2 publications with DICER1 and EIF2C4
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 MicroRNA (miRNA) Biogenesis Pathway antibodies  MicroRNA (miRNA) Biogenesis Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Regulatory RNA Pathways antibodies  Regulatory RNA Pathways Diagram
 Small Interfering RNA (siRNA) Biogenesis Pathway antibodies  Small Interfering RNA (siRNA) Biogenesis Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with anti-DICER1 antibody
 Disease Name  Pubmed Publications
 Pleuropulmonary blastoma Antibodies  >34 publications with DICER1 and Pleuropulmonary blastoma
 Lung Neoplasms Antibodies  >28 publications with DICER1 and Lung Neoplasms
 Disease Models, Animal Antibodies  >26 publications with DICER1 and Disease Models, Animal
 Inflammation Antibodies  >22 publications with DICER1 and Inflammation
 Adenocarcinoma Antibodies  >21 publications with DICER1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >20 publications with DICER1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >19 publications with DICER1 and Nervous System Diseases
 Lung Diseases Antibodies  >18 publications with DICER1 and Lung Diseases
 Kidney Diseases Antibodies  >15 publications with DICER1 and Kidney Diseases
 Infertility, Male Antibodies  >13 publications with DICER1 and Infertility, Male
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