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anti-DLAT antibody :: Rabbit dihydrolipoamide S-acetyltransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711211 anti-DLAT antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

dihydrolipoamide S-acetyltransferase (DLAT), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human dihydrolipoamide S-acetyltransferase polyclonal Antibody

 Product Synonym Names    dihydrolipoamide S-acetyltransferase; DLAT; DLTA; PDC-E2; PDCE2
 Product Gene Name   

anti-DLAT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608770
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DLAT
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16892 / sc-16890 / sc-32925
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DLAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DLAT purchase    The relevance of mitochondrial dysfunction in human disease is an increasingly important topic, as judged by the number of recent Pubmed articles. Human dihydrolipoamide acetyltransferase is a critical component of the pyruvate dehydrogenase complex - TCA Cycle - in the outer membrane and mutations in the DLAT gene can result in metabolism disorders, while the acetyltransferase component is highly antigenic and may lead to autoantigen primary biliary cirrhosis (PBC). Thus, research into both mechanism and drug discovery may provide clues to correct function of this E2 component pyruvate dehydrogenase activity. A rabbit polyclonal DLAT antibody has been validated for use in ELISA and western blot cell applications, has broad reactivity, excellent protein specificity and can detection low expression. Compared to mouse products, this polyclonal antibody recognizes a 70 kDa product and results are included with specific loading control on datasheet for antibodies. Suggested uses include metabolic process experimentation.
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 Applications Tested/Suitable for anti-DLAT antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DLAT. It may not necessarily be applicable to this product.
 NCBI GI #    25058600
 NCBI GeneID    1737
 NCBI Accession #    AAH39084.1 [Other Products]
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 UniProt Secondary Accession #    Q16783; Q53EP3 [Other Products]
 UniProt Related Accession #    P10515 [Other Products]
 Molecular Weight    68,997 Da [Similar Products]
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 NCBI Official Full Name    Dihydrolipoamide S-acetyltransferase
 NCBI Official Synonym Full Names    dihydrolipoamide S-acetyltransferase
 NCBI Official Symbol    DLAT [Similar Products]
 NCBI Official Synonym Symbols   
DLTA; PDCE2; PDC-E2
[Similar Products]
 NCBI Protein Information    dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; PBC; M2 antigen complex 70 kDa subunit; pyruvate dehydrogenase complex component E2; E2 component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial
 UniProt Protein Name    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
 UniProt Synonym Protein Names   
70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2; PDC-E2; PDCE2
 Protein Family    Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
 UniProt Gene Name    DLAT [Similar Products]
 UniProt Synonym Gene Names    DLTA; PBC; PDC-E2; PDCE2 [Similar Products]
 UniProt Entry Name    ODP2_HUMAN
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 NCBI Summary for DLAT    This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
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 UniProt Comments for DLAT    DLAT: the E2 component of the pyruvate dehydrogenase complex (PDHC) that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. Contains two lipoyl-binding domains. The PDHC plays a major role in controlling the balance between lipid and glucose oxidation depending on substrate availability. The activity of the PDHC is tightly regulated by phosphorylation of the E1 components by the PDHKs. The pyruvate dehydrogenase (PDH) holoenzyme is a multi-enzyme complex (PDHC) that contains 20-30 copies of pyruvate decarboxylase tetramers (2 alpha:2 beta)(E1), 60 copies of dihydrolipoamide acetyltransferase (E2), six homo-dimers of dihydrolipoamide dehydrogenase (E3), plus E3 binding proteins. PDHKs are recruited to the PDHC by binding to a lipoyl group covalently attached to K174 of the inner lipoyl domain of the E2 component.

Protein type: Mitochondrial; Carbohydrate Metabolism - pyruvate; EC 2.3.1.12; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - citrate (TCA) cycle; Transferase

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex

Molecular Function: dihydrolipoyllysine-residue acetyltransferase activity; protein binding

Biological Process: cellular metabolic process; tricarboxylic acid cycle; glucose metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; pyruvate metabolic process

Disease: Pyruvate Dehydrogenase E2 Deficiency
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 Research Articles on DLAT    1. Results show that DLAT and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DLAT antibodyPathways associated with anti-DLAT antibody
 Reference Product  PubMed Publications
 PDHB antibody  >4 publications with DLAT and PDHB
 PDHX antibody  >3 publications with DLAT and PDHX
 PDHA1 antibody  >3 publications with DLAT and PDHA1
 DLD antibody  >2 publications with DLAT and DLD
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis And Gluconeogenesis Pathway antibodies  Glycolysis And Gluconeogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
Diseases associated with anti-DLAT antibodyOrgans/Tissues associated with anti-DLAT antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >24 publications with DLAT and Liver Diseases
 Cholestasis Antibodies  >22 publications with DLAT and Cholestasis
 Nervous System Diseases Antibodies  >9 publications with DLAT and Nervous System Diseases
 Pyruvate Dehydrogenase E2 Deficiency Antibodies  >6 publications with DLAT and Pyruvate Dehydrogenase E2 Deficiency
 Brain Diseases Antibodies  >5 publications with DLAT and Brain Diseases
 Inflammation Antibodies  >4 publications with DLAT and Inflammation
 Neurobehavioral Manifestations Antibodies  >4 publications with DLAT and Neurobehavioral Manifestations
 Fatty Liver Antibodies  >3 publications with DLAT and Fatty Liver
 Lung Neoplasms Antibodies  >2 publications with DLAT and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with DLAT and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >29 publications with DLAT and Liver
 Blood Antibodies  >20 publications with DLAT and Blood
 Brain Antibodies  >5 publications with DLAT and Brain
 Lung Antibodies  >4 publications with DLAT and Lung
 Muscle Antibodies  >3 publications with DLAT and Muscle
 Spleen Antibodies  >3 publications with DLAT and Spleen
 Heart Antibodies  >3 publications with DLAT and Heart
 Kidney Antibodies  >2 publications with DLAT and Kidney
 Ascites Antibodies  >2 publications with DLAT and Ascites
 Eye Antibodies  >2 publications with DLAT and Eye
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