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anti-DISC1 antibody :: Rabbit anti-Human disrupted in schizophrenia 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710806 anti-DISC1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

disrupted in schizophrenia 1 (DISC1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human disrupted in schizophrenia 1 polyclonal Antibody

 Product Synonym Names    disrupted in schizophrenia 1; DISC1; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9
 Product Gene Name   

anti-DISC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605210
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DISC1-long-specific
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47988 / sc-134505
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DISC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DISC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for DISC1. It may not necessarily be applicable to this product.
 NCBI GI #    61742829
 NCBI GeneID    27185
 NCBI Accession #    NP_001012977.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001012959.1 [Other Products]
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 UniProt Secondary Accession #    O75045; Q5VT44; A6NLH2; C4P091; C4P095; C4P0A1; C4P0A3; C4P0B3; C4P0B6; C4P0C1; C9J6D0 [Other Products]
 UniProt Related Accession #    Q9NRI5 [Other Products]
 Molecular Weight    22,198 Da [Similar Products]
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 NCBI Official Full Name    disrupted in schizophrenia 1 protein isoform S
 NCBI Official Synonym Full Names    disrupted in schizophrenia 1
 NCBI Official Symbol    DISC1 [Similar Products]
 NCBI Official Synonym Symbols   
SCZD9; C1orf136
[Similar Products]
 NCBI Protein Information    disrupted in schizophrenia 1 protein
 UniProt Protein Name    Disrupted in schizophrenia 1 protein
 Protein Family    Disrupted in schizophrenia
 UniProt Gene Name    DISC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0457 [Similar Products]
 UniProt Entry Name    DISC1_HUMAN
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 NCBI Summary for DISC1    This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DISC1    DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: postsynaptic membrane; microtubule; centrosome; mitochondrion; postsynaptic density; cell junction

Molecular Function: protein binding

Biological Process: positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; TOR signaling pathway; cell proliferation in forebrain; neuron migration; cerebral cortex radially oriented cell migration; microtubule cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin; positive regulation of Wnt receptor signaling pathway

Disease: Schizophrenia; Schizophrenia 9
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 Research Articles on DISC1    1. A possible link is discovered between a DISC1 mutation and the cannabinoid system in a mouse model of schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-DISC1 antibodyOrgans/Tissues associated with anti-DISC1 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >478 publications with DISC1 and Schizophrenia
 Cognition Disorders Antibodies  >25 publications with DISC1 and Cognition Disorders
 Learning Disorders Antibodies  >18 publications with DISC1 and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >15 publications with DISC1 and Neurobehavioral Manifestations
 Abnormalities, Multiple Antibodies  >12 publications with DISC1 and Abnormalities, Multiple
 Congenital Abnormalities Antibodies  >9 publications with DISC1 and Congenital Abnormalities
 Prenatal Exposure Delayed Effects Antibodies  >7 publications with DISC1 and Prenatal Exposure Delayed Effects
 Autistic Disorder Antibodies  >7 publications with DISC1 and Autistic Disorder
 Asperger Syndrome Antibodies  >5 publications with DISC1 and Asperger Syndrome
 Weight Loss Antibodies  >3 publications with DISC1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >386 publications with DISC1 and Nerve
 Brain Antibodies  >311 publications with DISC1 and Brain
 Embryonic Tissue Antibodies  >30 publications with DISC1 and Embryonic Tissue
 Blood Antibodies  >19 publications with DISC1 and Blood
 Muscle Antibodies  >8 publications with DISC1 and Muscle
 Kidney Antibodies  >5 publications with DISC1 and Kidney
 Heart Antibodies  >4 publications with DISC1 and Heart
 Lung Antibodies  >2 publications with DISC1 and Lung
 Bone Antibodies  >2 publications with DISC1 and Bone
 Ganglia Antibodies  >2 publications with DISC1 and Ganglia
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