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anti-DCLK1 antibody :: Rabbit doublecortin-like kinase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719165 anti-DCLK1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

doublecortin-like kinase 1 (DCLK1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human doublecortin-like kinase 1 polyclonal Antibody

 Product Synonym Names    doublecortin-like kinase 1; DCLK1; DCAMKL1; DCDC3A; DCLK; KIAA0369
 Product Gene Name   

anti-DCLK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604742
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human DCLK1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46312 / sc-46311 / sc-66857 / sc-130735
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-DCLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-DCLK1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for DCLK1. It may not necessarily be applicable to this product.
 NCBI GI #    156230969
 NCBI GeneID    9201
 NCBI Accession #    AAI52457.1 [Other Products]
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 UniProt Secondary Accession #    Q5VZY8; Q5VZZ0; Q5VZZ1; B7Z3E9 [Other Products]
 UniProt Related Accession #    O15075 [Other Products]
 Molecular Weight    47,681 Da [Similar Products]
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 NCBI Official Full Name    Doublecortin-like kinase 1
 NCBI Official Synonym Full Names    doublecortin-like kinase 1
 NCBI Official Symbol    DCLK1 [Similar Products]
 NCBI Official Synonym Symbols   
CL1; DCLK; CLICK1; DCDC3A; DCAMKL1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase DCLK1; doublecortin-like and CAM kinase-like 1; doublecortin domain-containing protein 3A
 UniProt Protein Name    Serine/threonine-protein kinase DCLK1
 UniProt Synonym Protein Names   
Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    DCLK1 [Similar Products]
 UniProt Synonym Gene Names    DCAMKL1; DCDC3A; KIAA0369 [Similar Products]
 UniProt Entry Name    DCLK1_HUMAN
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 NCBI Summary for DCLK1    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
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 UniProt Comments for DCLK1    DCAMKL1: a serine-threonine kinase of the CAMK family. May be involved in a calcium-signaling pathway controling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Genetic and physical interactions with Doublecortin, which causes lissencephaly. A putative marker of quiescent stem cells. Four alternatively spliced isoforms have been described.

Protein type: EC 2.7.11.1; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; CAMK group; DCAMKL family

Chromosomal Location of Human Ortholog: 13q13

Cellular Component: integral to plasma membrane

Molecular Function: protein serine/threonine kinase activity; receptor signaling protein activity; ATP binding; protein kinase activity

Biological Process: nervous system development; central nervous system development; axon extension; dendrite morphogenesis; response to virus; forebrain development; neuron migration; central nervous system projection neuron axonogenesis; endosome transport; protein amino acid phosphorylation
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 Research Articles on DCLK1    1. XMD8-92 treatment results in inhibition of DCLK1 and downstream oncogenic pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DCLK1 antibodyDiseases associated with anti-DCLK1 antibody
 Reference Product  PubMed Publications
 LGR5 antibody  >16 publications with DCLK1 and LGR5
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with DCLK1 and Nervous System Diseases
 Colorectal Neoplasms Antibodies  >7 publications with DCLK1 and Colorectal Neoplasms
 Disease Models, Animal Antibodies  >6 publications with DCLK1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >5 publications with DCLK1 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >5 publications with DCLK1 and Liver Neoplasms
 Inflammation Antibodies  >5 publications with DCLK1 and Inflammation
 Liver Diseases Antibodies  >4 publications with DCLK1 and Liver Diseases
 Hyperplasia Antibodies  >4 publications with DCLK1 and Hyperplasia
 Precancerous Conditions Antibodies  >3 publications with DCLK1 and Precancerous Conditions
 Carcinoma, Hepatocellular Antibodies  >2 publications with DCLK1 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-DCLK1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with DCLK1 and Brain
 Nerve Antibodies  >18 publications with DCLK1 and Nerve
 Intestine Antibodies  >14 publications with DCLK1 and Intestine
 Embryonic Tissue Antibodies  >7 publications with DCLK1 and Embryonic Tissue
 Bone Antibodies  >3 publications with DCLK1 and Bone
 Stomach Antibodies  >3 publications with DCLK1 and Stomach
 Eye Antibodies  >3 publications with DCLK1 and Eye
 Ear Antibodies  >2 publications with DCLK1 and Ear
 Muscle Antibodies  >1 publications with DCLK1 and Muscle
 Lung Antibodies  >1 publications with DCLK1 and Lung
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