AAH62564.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Dyslexia susceptibility 1 candidate 1
NCBI Official Synonym Full Names
dyslexia susceptibility 1 candidate 1
NCBI Protein Information
dyslexia susceptibility 1 candidate gene 1 protein
UniProt Protein Name
Dyslexia susceptibility 1 candidate gene 1 protein
UniProt Synonym Gene Names
UniProt Entry Name
DYXC1_HUMAN
NCBI Summary for DYX1C1
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
UniProt Comments for DYX1C1
DYX1C1: Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1). A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21). 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; estrogen receptor binding
Biological Process: regulation of estrogen receptor signaling pathway; neuron migration; determination of left/right symmetry
Disease: Dyslexia, Susceptibility To, 1; Ciliary Dyskinesia, Primary, 25
Research Articles on DYX1C1
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Products associated with anti-DYX1C1 antibody
Diseases associated with anti-DYX1C1 antibody
Organs/Tissues associated with anti-DYX1C1 antibody
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