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anti-ENPP1 antibody :: Rabbit ectonucleotide pyrophosphatase/phosphodiesterase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716118 anti-ENPP1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human ectonucleotide pyrophosphatase/phosphodiesterase 1 polyclonal Antibody

 Product Synonym Names    ectonucleotide pyrophosphatase/phosphodiesterase 1; ENPP1; M6S1; NPP1; NPPS; PC-1; PCA1; PDNP1
 Product Gene Name   

anti-ENPP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615522
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ENPP1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23676 / sc-23677 / sc-33813
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ENPP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ENPP1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ENPP1. It may not necessarily be applicable to this product.
 NCBI GI #    133777224
 NCBI GeneID    5167
 NCBI Accession #    AAH59375.2 [Other Products]
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 UniProt Secondary Accession #    Q5T9R6; Q9NPZ3; Q9P1P6; Q9UP61; Q9Y6K3 [Other Products]
 UniProt Related Accession #    P22413 [Other Products]
 Molecular Weight    104,924 Da [Similar Products]
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 NCBI Official Full Name    Ectonucleotide pyrophosphatase/phosphodiesterase 1
 NCBI Official Synonym Full Names    ectonucleotide pyrophosphatase/phosphodiesterase 1
 NCBI Official Symbol    ENPP1 [Similar Products]
 NCBI Official Synonym Symbols   
M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1
[Similar Products]
 NCBI Protein Information    ectonucleotide pyrophosphatase/phosphodiesterase family member 1; E-NPP 1; Ly-41 antigen; alkaline phosphodiesterase 1; plasma-cell membrane glycoprotein 1; plasma-cell membrane glycoprotein PC-1; membrane component chromosome 6 surface marker 1; phosphodiesterase I/nucleotide pyrophosphatase 1; membrane component, chromosome 6, surface marker 1
 UniProt Protein Name    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
 UniProt Synonym Protein Names   
Membrane component chromosome 6 surface marker 1; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1Including the following 2 domains:Alkaline phosphodiesterase I (EC:3.1.4.1); Nucleotide pyrophosphatase (EC:3.6.1.9); NPPase
 Protein Family    Ectonucleotide pyrophosphatase/phosphodiesterase
 UniProt Gene Name    ENPP1 [Similar Products]
 UniProt Synonym Gene Names    M6S1; NPPS; PC1; PDNP1; E-NPP 1; NPPase [Similar Products]
 UniProt Entry Name    ENPP1_HUMAN
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 NCBI Summary for ENPP1    This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ENPP1    ENPP1: Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity. Homodimer; disulfide-linked. Interacts with INSR. Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. At low concentrations of ATP, a phosphorylated intermediate is formed which inhibits further hydrolysis. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: EC 3.6.1.9; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - purine; Membrane protein, integral; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Phosphodiesterase; Motility/polarity/chemotaxis; EC 3.1.4.1

Chromosomal Location of Human Ortholog: 6q22-q23

Cellular Component: extracellular space; cell surface; lysosomal membrane; integral to plasma membrane; basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function: phosphodiesterase I activity; nucleotide diphosphatase activity; protein homodimerization activity; 3'-phosphoadenosine 5'-phosphosulfate binding; zinc ion binding; calcium ion binding; nucleoside-triphosphate diphosphatase activity; insulin receptor binding; polysaccharide binding; protein binding; nucleic acid binding; ATP binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; sequestering of triacylglycerol; generation of precursor metabolites and energy; vitamin metabolic process; nucleoside triphosphate catabolic process; negative regulation of insulin receptor signaling pathway; negative regulation of fat cell differentiation; bone remodeling; phosphate metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; riboflavin metabolic process; negative regulation of glucose import; cellular phosphate ion homeostasis; cellular response to insulin stimulus; biomineral formation; negative regulation of ossification; immune response; negative regulation of protein amino acid autophosphorylation; negative regulation of cell growth; regulation of bone mineralization; inorganic diphosphate transport; water-soluble vitamin metabolic process; negative regulation of glycogen biosynthetic process

Disease: Obesity; Cole Disease; Arterial Calcification, Generalized, Of Infancy, 1; Hypophosphatemic Rickets, Autosomal Recessive, 2; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on ENPP1    1. Specific genotypes of the NPP1 gene IVS20-11delT and A533C SNPs may predict ossification of the posterior longitudinal ligament disease outcome after surgical intervention.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ENPP1 antibodyPathways associated with anti-ENPP1 antibody
 Reference Product  PubMed Publications
 NT5E antibody  >4 publications with ENPP1 and NT5E
 CD38 antibody  >1 publications with ENPP1 and CD38
 Products by Pathway  Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
 Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies  Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram
Diseases associated with anti-ENPP1 antibodyOrgans/Tissues associated with anti-ENPP1 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >62 publications with ENPP1 and Diabetes Mellitus, Type 2
 Obesity Antibodies  >54 publications with ENPP1 and Obesity
 Arterial calcification of infancy Antibodies  >29 publications with ENPP1 and Arterial calcification of infancy
 Kidney Diseases Antibodies  >19 publications with ENPP1 and Kidney Diseases
 Disease Models, Animal Antibodies  >14 publications with ENPP1 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >12 publications with ENPP1 and Congenital Abnormalities
 Hypertension Antibodies  >9 publications with ENPP1 and Hypertension
 Liver Diseases Antibodies  >9 publications with ENPP1 and Liver Diseases
 Inflammation Antibodies  >6 publications with ENPP1 and Inflammation
 Hypophosphatemic Rickets, Autosomal Recessive, 2 Antibodies  >5 publications with ENPP1 and Hypophosphatemic Rickets, Autosomal Recessive, 2
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >55 publications with ENPP1 and Bone
 Blood Antibodies  >49 publications with ENPP1 and Blood
 Heart Antibodies  >23 publications with ENPP1 and Heart
 Muscle Antibodies  >21 publications with ENPP1 and Muscle
 Kidney Antibodies  >18 publications with ENPP1 and Kidney
 Skin Antibodies  >16 publications with ENPP1 and Skin
 Connective Tissue Antibodies  >15 publications with ENPP1 and Connective Tissue
 Liver Antibodies  >14 publications with ENPP1 and Liver
 Embryonic Tissue Antibodies  >6 publications with ENPP1 and Embryonic Tissue
 Bone Marrow Antibodies  >4 publications with ENPP1 and Bone Marrow
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