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anti-EGLN3 antibody :: Rabbit egl nine homolog 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710110 anti-EGLN3 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

egl nine homolog 3 (EGLN3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human egl nine homolog 3 (C. elegans) polyclonal Antibody

 Product Synonym Names    egl nine homolog 3 (C. elegans); EGLN3; FLJ21620; HIFPH3; MGC125998; MGC125999; PHD3
 Product Gene Name   

anti-EGLN3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606426
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human EGLN3
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46030 / sc-46031
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EGLN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for EGLN3 purchase    Hypoxia effects is a good area of human research with relevance to cancer and neurodegeneration. Egl nine homology 3 EGLN 2 is an hypoxia inducible factor, in the HIF family. EGLN3 PHD3 is less well studied than HIF1, so it is an open avenue left to explore. To understand complex induction pathways and regulation, MyBiosource has teamed with Abgent to provide you with the top rabbit IgG polyclonal primary antibody for western blot, direct ELISA or IHC analysis. No other mouse mAb primary antibodies come close to our detection in cell lysates. This quality EGLN3 antibody detects human mouse protein equally and reacts to a wide range of secondary antibodies species. To learn more about our antibody services or to request quote for any of our anti HIF prolyl hydroxylase 3 products go to our website. You may win iPad mini by using promo code FLASH15.
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 Applications Tested/Suitable for anti-EGLN3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for EGLN3. It may not necessarily be applicable to this product.
 NCBI GI #    11545787
 NCBI GeneID    112399
 NCBI Accession #    NP_071356.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022073.3 [Other Products]
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 UniProt Secondary Accession #    Q2TA79; Q3B8N4; Q6P1R2 [Other Products]
 UniProt Related Accession #    Q9H6Z9 [Other Products]
 Molecular Weight    27,261 Da [Similar Products]
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 NCBI Official Full Name    egl nine homolog 3
 NCBI Official Synonym Full Names    egl-9 family hypoxia-inducible factor 3
 NCBI Official Symbol    EGLN3 [Similar Products]
 NCBI Official Synonym Symbols   
PHD3; HIFPH3; HIFP4H3
[Similar Products]
 NCBI Protein Information    egl nine homolog 3; HPH-1; HPH-3; HIF-PH3; HIF prolyl hydroxylase 3; HIF-prolyl hydroxylase 3; egl nine-like protein 3 isoform; hypoxia-inducible factor prolyl hydroxylase 3; prolyl hydroxylase domain-containing protein 3
 UniProt Protein Name    Egl nine homolog 3
 UniProt Synonym Protein Names   
HPH-1; Hypoxia-inducible factor prolyl hydroxylase 3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; Prolyl hydroxylase domain-containing protein 3; PHD3
 Protein Family    Egl nine
 UniProt Gene Name    EGLN3 [Similar Products]
 UniProt Synonym Gene Names    HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; PHD3 [Similar Products]
 UniProt Entry Name    EGLN3_HUMAN
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 UniProt Comments for EGLN3    EGLN3: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.

Protein type: Oxidoreductase; EC 1.14.11.29

Chromosomal Location of Human Ortholog: 14q13.1

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; L-ascorbic acid binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; peptidyl-proline 4-dioxygenase activity

Biological Process: caspase activation; apoptosis; regulation of neuron apoptosis; response to hypoxia; protein amino acid hydroxylation; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; response to DNA damage stimulus; regulation of cell proliferation
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 Research Articles on EGLN3    1. PHD3 depletion did not affect the expression of the PDH-E1alpha, E1beta, and E2 subunits, or the phosphorylation status of E1alpha, but destabilized the PDH complex (PDC), resulting in less functional PDC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EGLN3 antibodyPathways associated with anti-EGLN3 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >66 publications with EGLN3 and HIF1A
 EGLN1 antibody  >60 publications with EGLN3 and EGLN1
 VHL antibody  >26 publications with EGLN3 and VHL
 EGLN2 antibody  >24 publications with EGLN3 and EGLN2
 ARNT antibody  >6 publications with EGLN3 and ARNT
 EPAS1 antibody  >1 publications with EGLN3 and EPAS1
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies  Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
 Renal Cell Carcinoma Pathway antibodies  Renal Cell Carcinoma Pathway Diagram
 Renal Cell Carcinoma Pathway antibodies  Renal Cell Carcinoma Pathway Diagram
Diseases associated with anti-EGLN3 antibodyOrgans/Tissues associated with anti-EGLN3 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >16 publications with EGLN3 and Kidney Diseases
 Breast Neoplasms Antibodies  >12 publications with EGLN3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with EGLN3 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >8 publications with EGLN3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >7 publications with EGLN3 and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with EGLN3 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with EGLN3 and Liver Neoplasms
 Inflammation Antibodies  >5 publications with EGLN3 and Inflammation
 Nervous System Diseases Antibodies  >5 publications with EGLN3 and Nervous System Diseases
 Hypertension Antibodies  >4 publications with EGLN3 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >24 publications with EGLN3 and Kidney
 Heart Antibodies  >11 publications with EGLN3 and Heart
 Lung Antibodies  >9 publications with EGLN3 and Lung
 Brain Antibodies  >9 publications with EGLN3 and Brain
 Testis Antibodies  >3 publications with EGLN3 and Testis
 Skin Antibodies  >2 publications with EGLN3 and Skin
 Stomach Antibodies  >1 publications with EGLN3 and Stomach
 Prostate Antibodies  >1 publications with EGLN3 and Prostate
 Uterus Antibodies  >1 publications with EGLN3 and Uterus
 Connective Tissue Antibodies  >1 publications with EGLN3 and Connective Tissue
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