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anti-ENG antibody :: Rabbit endoglin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713266 anti-ENG antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

endoglin (ENG), Polyclonal Antibody

 Also Known As   

Rabbit anti-human endoglin polyclonal Antibody

 Product Synonym Names    endoglin; ENG; CD105; END; FLJ41744; HHT1; ORW; ORW1
 Product Gene Name   

anti-ENG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 187300
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ENG
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19790 / sc-23838 / sc-20632
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ENG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ENG antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ENG. It may not necessarily be applicable to this product.
 NCBI GI #    168693647
 NCBI GeneID    2022
 NCBI Accession #    NP_001108225.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114753.2 [Other Products]
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 UniProt Secondary Accession #    Q14248; Q14926; Q5T9C0 [Other Products]
 UniProt Related Accession #    P17813 [Other Products]
 Molecular Weight    67,542 Da [Similar Products]
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 NCBI Official Full Name    endoglin isoform 1
 NCBI Official Synonym Full Names    endoglin
 NCBI Official Symbol    ENG [Similar Products]
 NCBI Official Synonym Symbols   
END; HHT1; ORW1
[Similar Products]
 NCBI Protein Information    endoglin; CD105 antigen
 UniProt Protein Name    Endoglin
 UniProt Synonym Protein Names   
CD_antigen: CD105
 Protein Family    Endoglin
 UniProt Gene Name    ENG [Similar Products]
 UniProt Synonym Gene Names    END [Similar Products]
 UniProt Entry Name    EGLN_HUMAN
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 NCBI Summary for ENG    This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for ENG    ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: nucleoplasm; extracellular space; focal adhesion; cell surface; cytoplasm; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; protein homodimerization activity; transmembrane receptor activity; glycosaminoglycan binding; transforming growth factor beta binding; galactose binding; punt binding; activin binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: wound healing; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; response to corticosteroid stimulus; BMP signaling pathway; smooth muscle development; extracellular matrix disassembly; central nervous system vasculogenesis; venous blood vessel morphogenesis; regulation of transforming growth factor beta receptor signaling pathway; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; chronological cell aging; vasculogenesis; cell adhesion; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of cell adhesion; cell migration; regulation of phosphorylation; negative regulation of nitric-oxide synthase activity; regulation of cell proliferation; patterning of blood vessels; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber
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 Research Articles on ENG    1. molecular disturbances in S100A4 and endoglin expression might regulate the formation of cervical metastasis in HNSCC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ENG antibodyPathways associated with anti-ENG antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >322 publications with ENG and TGFB1
 ACVRL1 antibody  >157 publications with ENG and ACVRL1
 BMP2 antibody  >127 publications with ENG and BMP2
 SMAD4 antibody  >48 publications with ENG and SMAD4
 HIF1A antibody  >36 publications with ENG and HIF1A
 TGFBR2 antibody  >6 publications with ENG and TGFBR2
 TGFBR1 antibody  >5 publications with ENG and TGFBR1
 CDH5 antibody  >1 publications with ENG and CDH5
 TGFBI antibody  >1 publications with ENG and TGFBI
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-ENG antibodyOrgans/Tissues associated with anti-ENG antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6312 publications with ENG and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5497 publications with ENG and Cardiovascular Diseases
 Heart Diseases Antibodies  >2867 publications with ENG and Heart Diseases
 Breast Neoplasms Antibodies  >744 publications with ENG and Breast Neoplasms
 Disease Models, Animal Antibodies  >716 publications with ENG and Disease Models, Animal
 Inflammation Antibodies  >603 publications with ENG and Inflammation
 Hypertension Antibodies  >586 publications with ENG and Hypertension
 Liver Diseases Antibodies  >463 publications with ENG and Liver Diseases
 Atherosclerosis Antibodies  >427 publications with ENG and Atherosclerosis
 Necrosis Antibodies  >393 publications with ENG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10876 publications with ENG and Blood
 Bone Antibodies  >7689 publications with ENG and Bone
 Heart Antibodies  >7577 publications with ENG and Heart
 Brain Antibodies  >7467 publications with ENG and Brain
 Muscle Antibodies  >6714 publications with ENG and Muscle
 Vascular Antibodies  >6614 publications with ENG and Vascular
 Nerve Antibodies  >2848 publications with ENG and Nerve
 Skin Antibodies  >2757 publications with ENG and Skin
 Connective Tissue Antibodies  >2342 publications with ENG and Connective Tissue
 Eye Antibodies  >1947 publications with ENG and Eye
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