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anti-EPHX2 antibody :: Rabbit anti-Human epoxide hydrolase 2, cytoplasmic Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714479 anti-EPHX2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

epoxide hydrolase 2, cytoplasmic (EPHX2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human epoxide hydrolase 2, cytoplasmic polyclonal Antibody

 Product Synonym Names    epoxide hydrolase 2; cytoplasmic; EPHX2; CEH; SEH
 Product Gene Name   

anti-EPHX2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    132811
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human EPHX2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-25797 / sc-87099 / sc-87101
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EPHX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EPHX2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for EPHX2. It may not necessarily be applicable to this product.
 NCBI GI #    15530199
 NCBI GeneID    2053
 NCBI Accession #    AAH13874.1 [Other Products]
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 UniProt Secondary Accession #    Q16764; Q9HBJ1; Q9HBJ2; B2Z3B1; B3KTU8; B3KUA0; G3V134; J3KPH7 [Other Products]
 UniProt Related Accession #    P34913 [Other Products]
 Molecular Weight    55,626 Da [Similar Products]
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 NCBI Official Full Name    Epoxide hydrolase 2, cytoplasmic
 NCBI Official Synonym Full Names    epoxide hydrolase 2, cytoplasmic
 NCBI Official Symbol    EPHX2 [Similar Products]
 NCBI Official Synonym Symbols   
CEH; SEH
[Similar Products]
 NCBI Protein Information    bifunctional epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase, soluble; epoxide hydrolase 2, cytosolic
 UniProt Protein Name    Bifunctional epoxide hydrolase 2
 UniProt Synonym Protein Names   
Epoxide hydratase; Soluble epoxide hydrolase; SEH
 Protein Family    Bifunctional epoxide hydrolase
 UniProt Gene Name    EPHX2 [Similar Products]
 UniProt Synonym Gene Names    CEH; SEH [Similar Products]
 UniProt Entry Name    HYES_HUMAN
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 NCBI Summary for EPHX2    This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
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 UniProt Comments for EPHX2    EPHX2: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo- 9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy- octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.

Protein type: Lipid Metabolism - arachidonic acid; EC 3.3.2.10; EC 3.1.3.76; Hydrolase

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; peroxisome; cytosol

Molecular Function: toxin binding; protein homodimerization activity; lipid-phosphate phosphatase activity; epoxide hydrolase activity; phosphoric monoester hydrolase activity; magnesium ion binding; lipid phosphatase activity; receptor binding

Biological Process: cellular calcium ion homeostasis; cholesterol homeostasis; dephosphorylation; response to toxin; regulation of blood pressure; xenobiotic metabolic process; arachidonic acid metabolic process; epoxygenase P450 pathway; stilbene catabolic process; positive regulation of vasodilation; drug metabolic process; inflammatory response; phospholipid dephosphorylation

Disease: Hypercholesterolemia, Familial
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 Research Articles on EPHX2    1. Presence of single nucleotide polymorphism rs751141 of EPHX2 is associated with significantly increased risk of atrial fibrillation recurrence following catheter ablation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPHX2 antibodyPathways associated with anti-EPHX2 antibody
 Reference Product  PubMed Publications
 CYP2J2 antibody  >7 publications with EPHX2 and CYP2J2
 CYP2C9 antibody  >3 publications with EPHX2 and CYP2C9
 CYP2C8 antibody  >2 publications with EPHX2 and CYP2C8
 CYP2C19 antibody  >1 publications with EPHX2 and CYP2C19
 Products by Pathway  Pathway Diagram
 Arachidonate Epoxygenase / Epoxide Hydrolase Pathway antibodies  Arachidonate Epoxygenase / Epoxide Hydrolase Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Synthesis Of Epoxy (EET) And Dihydroxyeicosatrienoic Acids (DHET) Pathway antibodies  Synthesis Of Epoxy (EET) And Dihydroxyeicosatrienoic Acids (DHET) Pathway Diagram
Diseases associated with anti-EPHX2 antibodyOrgans/Tissues associated with anti-EPHX2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >60 publications with EPHX2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >29 publications with EPHX2 and Heart Diseases
 Hypertension Antibodies  >25 publications with EPHX2 and Hypertension
 Inflammation Antibodies  >24 publications with EPHX2 and Inflammation
 Nervous System Diseases Antibodies  >18 publications with EPHX2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >18 publications with EPHX2 and Disease Models, Animal
 Brain Diseases Antibodies  >18 publications with EPHX2 and Brain Diseases
 Hypertrophy Antibodies  >11 publications with EPHX2 and Hypertrophy
 Kidney Diseases Antibodies  >9 publications with EPHX2 and Kidney Diseases
 Atherosclerosis Antibodies  >8 publications with EPHX2 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with EPHX2 and Blood
 Heart Antibodies  >29 publications with EPHX2 and Heart
 Kidney Antibodies  >20 publications with EPHX2 and Kidney
 Brain Antibodies  >19 publications with EPHX2 and Brain
 Muscle Antibodies  >18 publications with EPHX2 and Muscle
 Liver Antibodies  >13 publications with EPHX2 and Liver
 Lung Antibodies  >7 publications with EPHX2 and Lung
 Pancreas Antibodies  >4 publications with EPHX2 and Pancreas
 Adrenal Gland Antibodies  >3 publications with EPHX2 and Adrenal Gland
 Intestine Antibodies  >3 publications with EPHX2 and Intestine
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