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anti-EIF4G1 antibody :: Rabbit eukaryotic translation initiation factor 4 gamma, 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710748 anti-EIF4G1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human eukaryotic translation initiation factor 4 gamma, 1 polyclonal Antibody

 Product Synonym Names    eukaryotic translation initiation factor 4 gamma; 1; EIF4G1; DKFZp686A1451; EIF4F; EIF4G; p220
 Product Gene Name   

anti-EIF4G1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614251
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human EIF4G1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9602 / sc-9601 / sc-11373
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EIF4G1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EIF4G1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for EIF4G1. It may not necessarily be applicable to this product.
 NCBI GI #    302699237
 NCBI GeneID    1981
 NCBI Accession #    NP_886553.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_182917.4 [Other Products]
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 UniProt Secondary Accession #    O43177; O95066; Q5HYG0; Q6ZN21; Q8N102; D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1 [Other Products]
 UniProt Related Accession #    Q04637 [Other Products]
 Molecular Weight    176,237 Da [Similar Products]
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 NCBI Official Full Name    eukaryotic translation initiation factor 4 gamma 1 isoform 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4 gamma, 1
 NCBI Official Symbol    EIF4G1 [Similar Products]
 NCBI Official Synonym Symbols   
P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4 gamma 1; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G
 UniProt Protein Name    Eukaryotic translation initiation factor 4 gamma 1
 UniProt Synonym Protein Names   
p220
 Protein Family    Eukaryotic translation initiation factor
 UniProt Gene Name    EIF4G1 [Similar Products]
 UniProt Synonym Gene Names    EIF4F; EIF4G; EIF4GI; eIF-4-gamma 1; eIF-4G 1; eIF-4G1 [Similar Products]
 UniProt Entry Name    IF4G1_HUMAN
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 NCBI Summary for EIF4G1    The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
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 UniProt Comments for EIF4G1    eIF4G: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. Belongs to the eIF4G family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation initiation; Translation; RNA-binding

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: poly(A) tail shortening; cellular protein metabolic process; viral reproduction; translation; cytokine and chemokine mediated signaling pathway; mRNA catabolic process, nonsense-mediated decay; insulin receptor signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; regulation of translational initiation
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 Research Articles on EIF4G1    1. study revealed that the EIF4G1 R1205H and VPS35 D620N mutations were absent in 418 Parkinsoin Disease patients of various South African ethnic groups
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EIF4G1 antibodyPathways associated with anti-EIF4G1 antibody
 Reference Product  PubMed Publications
 EIF4E antibody  >45 publications with EIF4G1 and EIF4E
 EIF4EBP1 antibody  >9 publications with EIF4G1 and EIF4EBP1
 EIF4A1 antibody  >2 publications with EIF4G1 and EIF4A1
 EIF4A2 antibody  >1 publications with EIF4G1 and EIF4A2
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
Diseases associated with anti-EIF4G1 antibodyOrgans/Tissues associated with anti-EIF4G1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >26 publications with EIF4G1 and Nervous System Diseases
 Brain Diseases Antibodies  >25 publications with EIF4G1 and Brain Diseases
 Neoplasm Metastasis Antibodies  >6 publications with EIF4G1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with EIF4G1 and Breast Neoplasms
 Skin Diseases Antibodies  >5 publications with EIF4G1 and Skin Diseases
 Neoplasm Invasiveness Antibodies  >3 publications with EIF4G1 and Neoplasm Invasiveness
 Neoplasms, Experimental Antibodies  >2 publications with EIF4G1 and Neoplasms, Experimental
 Pain Antibodies  >2 publications with EIF4G1 and Pain
 Ovarian Diseases Antibodies  >1 publications with EIF4G1 and Ovarian Diseases
 Hypertrophy Antibodies  >1 publications with EIF4G1 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with EIF4G1 and Blood
 Mouth Antibodies  >9 publications with EIF4G1 and Mouth
 Lung Antibodies  >6 publications with EIF4G1 and Lung
 Brain Antibodies  >5 publications with EIF4G1 and Brain
 Kidney Antibodies  >4 publications with EIF4G1 and Kidney
 Vascular Antibodies  >4 publications with EIF4G1 and Vascular
 Lymph Antibodies  >3 publications with EIF4G1 and Lymph
 Lymph Node Antibodies  >3 publications with EIF4G1 and Lymph Node
 Muscle Antibodies  >3 publications with EIF4G1 and Muscle
 Liver Antibodies  >2 publications with EIF4G1 and Liver
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