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anti-EIF4E antibody :: Rabbit eukaryotic translation initiation factor 4E Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712008 anti-EIF4E antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

eukaryotic translation initiation factor 4E (EIF4E), Polyclonal Antibody

 Also Known As   

Rabbit anti-human eukaryotic translation initiation factor 4E polyclonal Antibody

 Product Synonym Names    eukaryotic translation initiation factor 4E; EIF4E; CBP; EIF4E1; EIF4EL1; EIF4F; MGC111573
 Product Gene Name   

anti-EIF4E antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615091
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human CBP,EIF4E
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6968 / sc-6967 / sc-13963
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-EIF4E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EIF4E antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for EIF4E. It may not necessarily be applicable to this product.
 NCBI GI #    1352435
 NCBI GeneID    1977
 NCBI Accession #    P06730.2 [Other Products]
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 UniProt Secondary Accession #    Q96E95; B7Z6V1; D6RCQ6 [Other Products]
 UniProt Related Accession #    P06730 [Other Products]
 Molecular Weight    27,260 Da [Similar Products]
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 NCBI Official Full Name    Eukaryotic translation initiation factor 4E
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E
 NCBI Official Symbol    EIF4E [Similar Products]
 NCBI Official Synonym Symbols   
CBP; EIF4F; AUTS19; EIF4E1; EIF4EL1
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E
 UniProt Synonym Protein Names   
eIF-4F 25 kDa subunit; mRNA cap-binding protein
 Protein Family    Eukaryotic translation initiation factor
 UniProt Gene Name    EIF4E [Similar Products]
 UniProt Synonym Gene Names    EIF4EL1; EIF4F; eIF-4E; eIF4E [Similar Products]
 UniProt Entry Name    IF4E_HUMAN
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 NCBI Summary for EIF4E    The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for EIF4E    EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: mRNA cap complex; stress granule; cytoplasm; eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity; RNA cap binding

Biological Process: regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; translation; viral reproduction; cytokine and chemokine mediated signaling pathway; translational initiation; insulin receptor signaling pathway; gene expression; positive regulation of mitotic cell cycle; G1/S transition of mitotic cell cycle; lung development; mRNA catabolic process, deadenylation-dependent decay

Disease: Autism, Susceptibility To, 19
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 Research Articles on EIF4E    1. High expression of p-Mnk1 and p-eIF4E might be novel valuable biomarkers to predict poor prognosis of nasopharyngeal carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EIF4E antibodyPathways associated with anti-EIF4E antibody
 Reference Product  PubMed Publications
 MTOR antibody  >754 publications with EIF4E and MTOR
 EIF4EBP1 antibody  >507 publications with EIF4E and EIF4EBP1
 MKNK1 antibody  >81 publications with EIF4E and MKNK1
 EIF4EBP2 antibody  >49 publications with EIF4E and EIF4EBP2
 RPS6 antibody  >45 publications with EIF4E and RPS6
 EIF4G1 antibody  >45 publications with EIF4E and EIF4G1
 MKNK2 antibody  >30 publications with EIF4E and MKNK2
 EIF4G2 antibody  >18 publications with EIF4E and EIF4G2
 EIF4EBP3 antibody  >11 publications with EIF4E and EIF4EBP3
 EIF4G3 antibody  >3 publications with EIF4E and EIF4G3
 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
Diseases associated with anti-EIF4E antibodyOrgans/Tissues associated with anti-EIF4E antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >104 publications with EIF4E and Breast Neoplasms
 Nervous System Diseases Antibodies  >82 publications with EIF4E and Nervous System Diseases
 Adenocarcinoma Antibodies  >79 publications with EIF4E and Adenocarcinoma
 Necrosis Antibodies  >60 publications with EIF4E and Necrosis
 Hypertrophy Antibodies  >58 publications with EIF4E and Hypertrophy
 Cardiovascular Diseases Antibodies  >53 publications with EIF4E and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >52 publications with EIF4E and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >51 publications with EIF4E and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >50 publications with EIF4E and Neoplasm Metastasis
 Brain Diseases Antibodies  >46 publications with EIF4E and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >340 publications with EIF4E and Muscle
 Blood Antibodies  >278 publications with EIF4E and Blood
 Liver Antibodies  >138 publications with EIF4E and Liver
 Brain Antibodies  >137 publications with EIF4E and Brain
 Vascular Antibodies  >115 publications with EIF4E and Vascular
 Heart Antibodies  >93 publications with EIF4E and Heart
 Lung Antibodies  >83 publications with EIF4E and Lung
 Kidney Antibodies  >71 publications with EIF4E and Kidney
 Nerve Antibodies  >44 publications with EIF4E and Nerve
 Pancreas Antibodies  >40 publications with EIF4E and Pancreas
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