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anti-FGA antibody :: anti-Mouse, rat fibrinogen antiserum Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135252 anti-FGA antibody
Unit / Price
1 mL  /  $345 +1 FREE 8GB USB
10 mL  /  $2,330 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

fibrinogen antiserum (FGA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti mouse fibrinogen antiserum

 Product Gene Name   

anti-FGA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000069.6 (83026153..83033627). Location: 3 F1; 3 36.96 cM
 3D Structure    ModBase 3D Structure for Q99K47
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Host: Rabbit; Source: Rabbit serum
 Species Reactivity    Mouse, rat
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 Purity/Purification    Serum
 Form/Format    Frozen liquid
 Concentration    Whole Antiserum (lot specific)
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 Immunogen    Full length native protein (purified) (Mouse).
 Target Information    Recognises Fibrinogen
 Target Molecular Weight    340000
 Antigen    Full length native protein (purified) (Mouse).
 Aliquot    1 x 1.0ml
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-FGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FGA antibody

   Polyclonal antiserum (host rabbit). Cross reacts with rat fibrinogen.
 Product Categories/Family for anti-FGA antibody    Fibrinogen; Polyclonal Antibodies to Mouse Fibrinogen
 Applications Tested/Suitable for anti-FGA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin

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NCBI/Uniprot data below describe general gene information for FGA. It may not necessarily be applicable to this product.
 NCBI GI #    33563252
 NCBI GeneID    14161
 NCBI Accession #    NP_034326.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010196.3 [Other Products]
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 UniProt Primary Accession #    Q99K47 [Other Products]
 UniProt Secondary Accession #    Q8K0E8; Q8VCM7 [Other Products]
 Molecular Weight    61,326 Da
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 NCBI Official Full Name    fibrinogen, alpha polypeptide isoform 2
 NCBI Official Synonym Full Names    fibrinogen alpha chain
 NCBI Official Symbol    Fga [Similar Products]
 NCBI Official Synonym Symbols   
Fib; ENSMUSG00000059807
[Similar Products]
 NCBI Protein Information    fibrinogen, alpha polypeptide; fibrinogen, A alpha polypeptide
 UniProt Protein Name    Fibrinogen, alpha polypeptide
 Protein Family    Fibrinogen
 UniProt Gene Name    Fga [Similar Products]
 UniProt Entry Name    Q99K47_MOUSE
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 NCBI Summary for FGA    This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and soft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
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 UniProt Comments for FGA    FGA: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGA are a cause of congenital afibrinogenemia (CAFBN). This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha- dysfibrinogenemias. Defects in FGA are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell surface; rough endoplasmic reticulum; cytoplasm; fibrinogen complex; extracellular region; cell cortex; vesicle; external side of plasma membrane

Molecular Function: protein binding, bridging; cell adhesion molecule binding; structural molecule activity; receptor binding

Biological Process: protein polymerization; platelet activation; positive regulation of heterotypic cell-cell adhesion; immune system process; cell-matrix adhesion; signal transduction; cellular protein complex assembly; positive regulation of protein secretion; hemostasis; positive regulation of vasoconstriction; innate immune response; blood coagulation; response to calcium ion; positive regulation of exocytosis
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 Research Articles on FGA    1. These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of acute kidney injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FGA antibodyDiseases associated with anti-FGA antibody
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin AlphaIIb Beta3 Signaling Pathway antibodies  Integrin AlphaIIb Beta3 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >46 publications with FGA and Cardiovascular Diseases
 Afibrinogenemia Antibodies  >44 publications with FGA and Afibrinogenemia
 Brain Diseases Antibodies  >28 publications with FGA and Brain Diseases
 Thrombosis Antibodies  >14 publications with FGA and Thrombosis
 Inflammation Antibodies  >10 publications with FGA and Inflammation
 Hypertension Antibodies  >9 publications with FGA and Hypertension
 Necrosis Antibodies  >9 publications with FGA and Necrosis
 Cognition Disorders Antibodies  >8 publications with FGA and Cognition Disorders
 Drug Toxicity Antibodies  >8 publications with FGA and Drug Toxicity
 Liver Diseases Antibodies  >8 publications with FGA and Liver Diseases
Organs/Tissues associated with anti-FGA antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >16 publications with FGA and Liver
 Lung Antibodies  >15 publications with FGA and Lung
 Muscle Antibodies  >8 publications with FGA and Muscle
 Kidney Antibodies  >7 publications with FGA and Kidney
 Uterus Antibodies  >5 publications with FGA and Uterus
 Embryonic Tissue Antibodies  >5 publications with FGA and Embryonic Tissue
 Stomach Antibodies  >1 publications with FGA and Stomach
 Tongue Antibodies  >1 publications with FGA and Tongue
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