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anti-FGG antibody :: Goat anti-Mouse fibrinogen Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS573027 anti-FGG antibody
Unit / Price
10 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

fibrinogen (FGG), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti Mouse fibrinogen

 Product Gene Name   

anti-FGG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; AC_000174.1 (2822885..2830961). Location: 17q12-q13
 3D Structure    ModBase 3D Structure for P12799
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Mouse
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 Specificity    Purified IgG fraction of polyclonal Goat antiSerum to Mouse fibrinogen
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 Product Type    Primary Antibodies
 Soure    Fibrinogen (clotting factor I) is a heat labile beta glycoprotein present in plasma. It is the precursor of fibrin, which is the key protein constituting the network of the blood clot. Thrombin converts fibrinogen to fibrin by limited proteolysis. Fibrin monomers polymerize to fibrin which is stabilized by cross-linking. Fibrinogen is isolated from fresh plasma after removing prothrombin. Freundís complete adjuvant is used in the first step of the immunization procedure.
 Reactivity Note    The antiSerum does not cross-react with any other component of Mouse plasma. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail.
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 Preparation and Storage    Lyophilized at +4 degree C--at least 10 years. Reconstituted at or below -20 degree C--3-5 years. Reconstituted at +4 degree C--7 days
 Other Notes    Small volumes of anti-FGG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FGG antibody

   The reactivity of the antiserum is restricted to fibrinogen. In immunoelectrophoresis and radial immunodiffusion (Ouchterlony), using various antiserum concentrations against normal mouse plasma a single precipitin line is obtained which shows a reaction of identity with the precipitin line obtained with purified fibrinogen. No reaction is obtained with any other plasma protein component or serum. However, the antiserum may also react with fibrin monomers, circulating fibrinopeptides and fibrin degradation products. As unlabelled primary or secondary antibody reagent for the indirect detection of fibrinogen in mouse cells, tissues and body fluids in immunofluorescence and immunoenzyme methods; for the production of immunoconjugates with a selected marker; to prepare insoluble immunoaffinity adsorbents by coupling to an artificial carrier; as catching or detection reagent in non-isotopic methodology and solid phase immunochemistry (e.g. ELISA, Western blotting). When applied in any cytochemical or histochemical procedure or solids phase coupling technique, the optimum concentration of the IgG preparation should always be established by titration.
 Product Categories/Family for anti-FGG antibody    Secondary Antibody, Veterinary , Wound healing , haematology
 Applications Tested/Suitable for anti-FGG antibody   

Indirect Immunofluorescence (IF), ELISA (EIA), Dot Blot (DB), Immunoblotting (IB)

 Application Notes for anti-FGG antibody    Indirect immunofluorescence,ELISA,Dot blot,Immunoblotting. The lyophilized IgG fraction is shipped at ambient temperature and may be stored at +4 degree C; prolonged storage at or below -20 degree C. Reconstitute the lyophilized antiserum by adding 1 ml sterile distilled water. Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at +4 degree C, not refrozen, and preferably used the same day.
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NCBI/Uniprot data below describe general gene information for FGG. It may not necessarily be applicable to this product.
 NCBI GI #    350
 NCBI GeneID    280792
 NCBI Accession #    CAA33562.1 [Other Products]
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 UniProt Primary Accession #    P12799 [Other Products]
 UniProt Related Accession #    P12799 [Other Products]
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 NCBI Official Full Name    fibrinogen
 NCBI Official Synonym Full Names    fibrinogen gamma chain<
 NCBI Official Symbol    FGG [Similar Products]
 NCBI Protein Information    fibrinogen gamma-B chain; gamma'; fibrinogen, gamma polypeptide
 UniProt Protein Name    Fibrinogen gamma-B chain
 Protein Family    Fibrinogen
 UniProt Gene Name    FGG [Similar Products]
 UniProt Synonym Gene Names    Gamma' [Similar Products]
 UniProt Entry Name    FIBG_BOVIN
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 UniProt Comments for FGG    Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subunit structure: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain

By similarity.

Subcellular location: Secreted.

Domain: A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.

Post-translational modification: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Sequence similarities: Contains 1 fibrinogen C-terminal domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FGG antibodyPathways associated with anti-FGG antibody
 Reference Product  PubMed Publications
 FGA antibody  >66 publications with FGG and FGA
 FGB antibody  >65 publications with FGG and FGB
 SERPINF2 antibody  >1 publications with FGG and SERPINF2
 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway antibodies  GRB2:SOS Provides Linkage To MAPK Signaling For Intergrins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin AlphaIIb Beta3 Signaling Pathway antibodies  Integrin AlphaIIb Beta3 Signaling Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Platelet Aggregation (Plug Formation) Pathway antibodies  Platelet Aggregation (Plug Formation) Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
Diseases associated with anti-FGG antibodyOrgans/Tissues associated with anti-FGG antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >158 publications with FGG and Cardiovascular Diseases
 Neoplasms Antibodies  >152 publications with FGG and Neoplasms
 Brain Diseases Antibodies  >92 publications with FGG and Brain Diseases
 Heart Diseases Antibodies  >82 publications with FGG and Heart Diseases
 Death Antibodies  >56 publications with FGG and Death
 Lung Diseases Antibodies  >43 publications with FGG and Lung Diseases
 Inflammation Antibodies  >33 publications with FGG and Inflammation
 Liver Diseases Antibodies  >31 publications with FGG and Liver Diseases
 Myocardial Infarction Antibodies  >30 publications with FGG and Myocardial Infarction
 Kidney Diseases Antibodies  >26 publications with FGG and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >73 publications with FGG and Brain
 Muscle Antibodies  >58 publications with FGG and Muscle
 Liver Antibodies  >48 publications with FGG and Liver
 Embryonic Tissue Antibodies  >14 publications with FGG and Embryonic Tissue
 Testis Antibodies  >13 publications with FGG and Testis
 Reticulum Antibodies  >5 publications with FGG and Reticulum
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