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anti-FRS2 antibody :: Rabbit fibroblast growth factor receptor substrate 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710247 anti-FRS2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

fibroblast growth factor receptor substrate 2 (FRS2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human fibroblast growth factor receptor substrate 2 polyclonal Antibody

 Product Synonym Names    fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
 Product Gene Name   

anti-FRS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607743
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human FRS2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-51489 / sc-51490 / sc-51489 / sc-51490 / sc-51491 / sc-8318
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FRS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FRS2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for FRS2. It may not necessarily be applicable to this product.
 NCBI GI #    110347408
 NCBI GeneID    10818
 NCBI Accession #    NP_006645.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006654.4 [Other Products]
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 UniProt Secondary Accession #    O43558; Q7LDQ6; B0LPF2; B2R684 [Other Products]
 UniProt Related Accession #    Q8WU20 [Other Products]
 Molecular Weight    57,029 Da [Similar Products]
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 NCBI Official Full Name    fibroblast growth factor receptor substrate 2
 NCBI Official Synonym Full Names    fibroblast growth factor receptor substrate 2
 NCBI Official Symbol    FRS2 [Similar Products]
 NCBI Official Synonym Symbols   
SNT; SNT1; FRS2A; SNT-1; FRS2alpha
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1
 UniProt Protein Name    Fibroblast growth factor receptor substrate 2
 UniProt Synonym Protein Names   
FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1
 Protein Family    Fibroblast growth factor receptor substrate
 UniProt Gene Name    FRS2 [Similar Products]
 UniProt Synonym Gene Names    FGFR substrate 2; SNT-1 [Similar Products]
 UniProt Entry Name    FRS2_HUMAN
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 UniProt Comments for FRS2    FRS2: an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: membrane; integral to plasma membrane; plasma membrane; intercellular junction; endosome

Molecular Function: protein binding; neurotrophin TRKA receptor binding; phosphatase activator activity; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; determination of anterior/posterior axis, embryo; induction of an organ; neuroblast proliferation; forebrain development; insulin receptor signaling pathway; innate immune response; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway
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 Research Articles on FRS2    1. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FRS2 antibodyPathways associated with anti-FRS2 antibody
 Reference Product  PubMed Publications
 FGFR1 antibody  >45 publications with FRS2 and FGFR1
 GRB2 antibody  >40 publications with FRS2 and GRB2
 SRC antibody  >32 publications with FRS2 and SRC
 FGFR2 antibody  >27 publications with FRS2 and FGFR2
 MAPK1 antibody  >15 publications with FRS2 and MAPK1
 PTPN11 antibody  >14 publications with FRS2 and PTPN11
 RET antibody  >11 publications with FRS2 and RET
 CBL antibody  >6 publications with FRS2 and CBL
 SOS1 antibody  >4 publications with FRS2 and SOS1
 CRK antibody  >4 publications with FRS2 and CRK
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
Diseases associated with anti-FRS2 antibodyOrgans/Tissues associated with anti-FRS2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with FRS2 and Breast Neoplasms
 Skin Diseases Antibodies  >5 publications with FRS2 and Skin Diseases
 Congenital Abnormalities Antibodies  >4 publications with FRS2 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >4 publications with FRS2 and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with FRS2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with FRS2 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with FRS2 and Kidney Diseases
 Neural Tube Defects Antibodies  >1 publications with FRS2 and Neural Tube Defects
 Fatty Liver Antibodies  >1 publications with FRS2 and Fatty Liver
 Hyperplasia Antibodies  >1 publications with FRS2 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with FRS2 and Brain
 Vascular Antibodies  >12 publications with FRS2 and Vascular
 Lung Antibodies  >8 publications with FRS2 and Lung
 Muscle Antibodies  >8 publications with FRS2 and Muscle
 Embryonic Tissue Antibodies  >7 publications with FRS2 and Embryonic Tissue
 Prostate Antibodies  >5 publications with FRS2 and Prostate
 Blood Antibodies  >5 publications with FRS2 and Blood
 Liver Antibodies  >5 publications with FRS2 and Liver
 Stomach Antibodies  >4 publications with FRS2 and Stomach
 Kidney Antibodies  >4 publications with FRS2 and Kidney
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