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anti-GRIN2A antibody :: Rabbit anti-Human, Mouse glutamate receptor, ionotropic, N-methyl D-aspartate 2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714853 anti-GRIN2A antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A), Polyclonal Antibody

 Also Known As   

Rabbit anti-human glutamate receptor, ionotropic, N-methyl D-aspartate 2A polyclonal Antibody

 Product Synonym Names    glutamate receptor; ionotropic; N-methyl D-aspartate 2A; GRIN2A; NMDAR2A; NR2A
 Product Gene Name   

anti-GRIN2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 245570
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human GRIN2A
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1468 / sc-31540 / sc-31541 / sc-31542 / sc-31539 / sc-9056
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GRIN2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GRIN2A antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for GRIN2A. It may not necessarily be applicable to this product.
 NCBI GI #    219519943
 NCBI GeneID    2903
 NCBI Accession #    AAI43274.1 [Other Products]
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 UniProt Secondary Accession #    O00669; Q17RZ6 [Other Products]
 UniProt Related Accession #    Q12879 [Other Products]
 Molecular Weight    144,431 Da [Similar Products]
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 NCBI Official Full Name    Glutamate receptor, ionotropic, N-methyl D-aspartate 2A
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, N-methyl D-aspartate 2A
 NCBI Official Symbol    GRIN2A [Similar Products]
 NCBI Official Synonym Symbols   
LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 2A
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN2A [Similar Products]
 UniProt Synonym Gene Names    NMDAR2A; GluN2A; NMDAR2A; NR2A; hNR2A [Similar Products]
 UniProt Entry Name    NMDE1_HUMAN
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 NCBI Summary for GRIN2A    This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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 UniProt Comments for GRIN2A    NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity

Biological Process: startle response; positive regulation of apoptosis; regulation of synaptic plasticity; sensory perception of pain; dopamine metabolic process; synaptic transmission; protein localization; learning and/or memory; transport; response to wounding; visual learning; serotonin metabolic process; response to drug; synaptic transmission, glutamatergic; glutamate signaling pathway; response to amphetamine; sleep; memory; response to ethanol; neurogenesis; directional locomotion; ionotropic glutamate receptor signaling pathway; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
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 Research Articles on GRIN2A    1. Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRIN2A antibodyPathways associated with anti-GRIN2A antibody
 Reference Product  PubMed Publications
 GRIN1 antibody  >17 publications with GRIN2A and GRIN1
 GRIN3A antibody  >3 publications with GRIN2A and GRIN3A
 DLG4 antibody  >2 publications with GRIN2A and DLG4
 CAMK2A antibody  >1 publications with GRIN2A and CAMK2A
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Diseases associated with anti-GRIN2A antibodyOrgans/Tissues associated with anti-GRIN2A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21 publications with GRIN2A and Nervous System Diseases
 Brain Diseases Antibodies  >20 publications with GRIN2A and Brain Diseases
 Epilepsy Antibodies  >16 publications with GRIN2A and Epilepsy
 Landau-Kleffner Syndrome Antibodies  >7 publications with GRIN2A and Landau-Kleffner Syndrome
 Melanoma Antibodies  >7 publications with GRIN2A and Melanoma
 Movement Disorders Antibodies  >7 publications with GRIN2A and Movement Disorders
 Epilepsy, Rolandic Antibodies  >6 publications with GRIN2A and Epilepsy, Rolandic
 Mood Disorders Antibodies  >5 publications with GRIN2A and Mood Disorders
 Seizures Antibodies  >4 publications with GRIN2A and Seizures
 Cognition Disorders Antibodies  >4 publications with GRIN2A and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >33 publications with GRIN2A and Brain
 Skin Antibodies  >4 publications with GRIN2A and Skin
 Blood Antibodies  >3 publications with GRIN2A and Blood
 Muscle Antibodies  >2 publications with GRIN2A and Muscle
 Eye Antibodies  >1 publications with GRIN2A and Eye
 Liver Antibodies  >1 publications with GRIN2A and Liver
 Embryonic Tissue Antibodies  >1 publications with GRIN2A and Embryonic Tissue
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