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anti-GZMA antibody :: Rabbit anti-Human granzyme A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719111 (SPECIAL PRICING: 1 unit is in stock at 40% OFF web price.
Please contact customer service for more information)
anti-GZMA antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

granzyme A (GZMA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) polyclonal Antibody

 Product Synonym Names    granzyme A (granzyme 1; cytotoxic T-lymphocyte-associated serine esterase 3); GZMA; CTLA3; HFSP
 Product Gene Name   

anti-GZMA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140050
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human GZMA
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5510 / sc-5511 / sc-11434
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GZMA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GZMA antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for GZMA. It may not necessarily be applicable to this product.
 NCBI GI #    4096788
 NCBI GeneID    3001
 NCBI Accession #    AAD00009.1 [Other Products]
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 UniProt Secondary Accession #    Q6IB36; A4PHN1 [Other Products]
 UniProt Related Accession #    P12544 [Other Products]
 Molecular Weight    27,109 Da [Similar Products]
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 NCBI Official Full Name    granzyme A, partial
 NCBI Official Synonym Full Names    granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
 NCBI Official Symbol    GZMA [Similar Products]
 NCBI Official Synonym Symbols   
HFSP; CTLA3
[Similar Products]
 NCBI Protein Information    granzyme A; HF; h factor; CTL tryptase; fragmentin-1; cytotoxic T-lymphocyte proteinase 1; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)
 UniProt Protein Name    Granzyme A
 UniProt Synonym Protein Names   
CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF
 Protein Family    Granzyme
 UniProt Gene Name    GZMA [Similar Products]
 UniProt Synonym Gene Names    CTLA3; HFSP; H factor; HF [Similar Products]
 UniProt Entry Name    GRAA_HUMAN
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 NCBI Summary for GZMA    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GZMA    GZMA: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.78; Apoptosis

Chromosomal Location of Human Ortholog: 5q11-q12

Cellular Component: extracellular region; immunological synapse; nucleus

Molecular Function: protein binding; protein homodimerization activity; serine-type endopeptidase activity

Biological Process: proteolysis involved in cellular protein catabolic process; apoptosis; positive regulation of apoptosis; cytolysis; negative regulation of oxidoreductase activity; negative regulation of endodeoxyribonuclease activity; immune response; negative regulation of DNA binding
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 Research Articles on GZMA    1. functional divergence between human and mouse granzyme A
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GZMA antibodyPathways associated with anti-GZMA antibody
 Reference Product  PubMed Publications
 PRF1 antibody  >144 publications with GZMA and PRF1
 CD2 antibody  >9 publications with GZMA and CD2
 GNLY antibody  >7 publications with GZMA and GNLY
 IL2 antibody  >2 publications with GZMA and IL2
 Products by Pathway  Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-GZMA antibodyOrgans/Tissues associated with anti-GZMA antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >33 publications with GZMA and Necrosis
 Inflammation Antibodies  >19 publications with GZMA and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with GZMA and Cardiovascular Diseases
 Gastrointestinal Diseases Antibodies  >5 publications with GZMA and Gastrointestinal Diseases
 Lung Diseases Antibodies  >4 publications with GZMA and Lung Diseases
 Liver Diseases Antibodies  >4 publications with GZMA and Liver Diseases
 Blood Coagulation Disorders Antibodies  >3 publications with GZMA and Blood Coagulation Disorders
 Liver Neoplasms Antibodies  >3 publications with GZMA and Liver Neoplasms
 Kidney Diseases Antibodies  >2 publications with GZMA and Kidney Diseases
 Lung Injury Antibodies  >2 publications with GZMA and Lung Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >267 publications with GZMA and Blood
 Spleen Antibodies  >11 publications with GZMA and Spleen
 Skin Antibodies  >11 publications with GZMA and Skin
 Lung Antibodies  >10 publications with GZMA and Lung
 Kidney Antibodies  >9 publications with GZMA and Kidney
 Heart Antibodies  >8 publications with GZMA and Heart
 Intestine Antibodies  >8 publications with GZMA and Intestine
 Uterus Antibodies  >5 publications with GZMA and Uterus
 Lymph Node Antibodies  >5 publications with GZMA and Lymph Node
 Brain Antibodies  >3 publications with GZMA and Brain
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