AAD00009.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
granzyme A, partial
NCBI Official Synonym Full Names
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
NCBI Official Synonym Symbols
NCBI Protein Information
granzyme A; HF; h factor; CTL tryptase; fragmentin-1; cytotoxic T-lymphocyte proteinase 1; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)
UniProt Protein Name
Granzyme A
UniProt Synonym Protein Names
CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF
UniProt Synonym Gene Names
UniProt Entry Name
GRAA_HUMAN
NCBI Summary for GZMA
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
UniProt Comments for GZMA
GZMA: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter.
Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.78; Apoptosis
Chromosomal Location of Human Ortholog: 5q11-q12
Cellular Component: extracellular region; immunological synapse; nucleus
Molecular Function: protein binding; protein homodimerization activity; serine-type endopeptidase activity
Biological Process: proteolysis involved in cellular protein catabolic process; apoptosis; positive regulation of apoptosis; cytolysis; negative regulation of oxidoreductase activity; negative regulation of endodeoxyribonuclease activity; immune response; negative regulation of DNA binding
Research Articles on GZMA
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Products associated with anti-GZMA antibody
Pathways associated with anti-GZMA antibody
Diseases associated with anti-GZMA antibody
Organs/Tissues associated with anti-GZMA antibody
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