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anti-hCG antibody :: Sheep hCG Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS220742 anti-hCG antibody
Unit / Price
1 mL  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

hCG, Polyclonal Antibody

 Also Known As   

SHEEP ANTI hCG (INTACT)

 Product Gene Name   

anti-hCG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    118850
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
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 Specificity    This item is specific for human chorionic gonadotrophin (hCG), a 30kD hormone produced by placental syncytiotrophoblasts. hCG acts to maintain the corpus luteum until the developing placenta is able to produce the required levels of oestrogen and progesterone.

hCG shares a common alpha chain with the pituitary hormones FSH, TSH and LH, but has a unique beta chain. This antibody reacts with intact hCG.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 5.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    Native hCG
Buffer Solution
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-hCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-hCG antibody

   MBS220742 is specific for human chorionic gonadotrophin (hCG), a 30kD hormone produced by placental syncytiotrophoblasts. hCG acts to maintain the corpus luteum until the developing placenta is able to produce the required levels of oestrogen and progesterone. hCG shares a common alpha chain with the pituitary hormones FSH, TSH and LH, but has a unique beta chain. This antibody reacts with intact hCG.
 Applications Tested/Suitable for anti-hCG antibody   

ELISA (EIA)

 Application Notes for anti-hCG antibody    ELISA: Minimum Dilution: 1/500; Maximum Dilution: 1/1000
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NCBI/Uniprot data below describe general gene information for hCG. It may not necessarily be applicable to this product.
 NCBI GI #    4502787
 NCBI GeneID    1081
 NCBI Accession #    NP_000726.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000735.3 [Other Products]
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 UniProt Related Accession #    P01215 [Other Products]
 Molecular Weight    13,075 Da
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 NCBI Official Full Name    glycoprotein hormones alpha chain isoform 2
 NCBI Official Synonym Full Names    glycoprotein hormones, alpha polypeptide
 NCBI Official Symbol    CGA [Similar Products]
 NCBI Official Synonym Symbols   
HCG; LHA; FSHA; GPHa; TSHA; GPHA1; CG-ALPHA
[Similar Products]
 NCBI Protein Information    glycoprotein hormones alpha chain; FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; choriogonadotropin alpha chain; chorionic gonadotrophin subunit alpha; chorionic gonadotropin, alpha polypeptide; follicle-stimulating hormone alpha chain; follicle-stimulating hormone alpha subunit; follitropin alpha chain; luteinizing hormone alpha chain; lutropin alpha chain; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain
 UniProt Protein Name    Glycoprotein hormones alpha chain
 UniProt Synonym Protein Names   
Anterior pituitary glycoprotein hormones common subunit alpha; Choriogonadotropin alpha chain; Chorionic gonadotrophin subunit alpha; CG-alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alpha; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; TSH-alpha; Thyrotropin alpha chain
 Protein Family    Hemocyanin
 UniProt Gene Name    CGA [Similar Products]
 UniProt Synonym Gene Names    CG-alpha; FSH-alpha; LSH-alpha; TSH-alpha [Similar Products]
 UniProt Entry Name    GLHA_HUMAN
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 NCBI Summary for hCG    The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for hCG    CGA: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6q12-q21

Cellular Component: extracellular region

Molecular Function: protein binding; hormone activity

Biological Process: cellular protein metabolic process; cell-cell signaling; peptide hormone processing; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of cell migration
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 Research Articles on hCG    1. A protective effect of hCG against breast cancer may be associated with its growth inhibitory and differentiation induction function in breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-hCG antibodyPathways associated with anti-hCG antibody
 Reference Product  PubMed Publications
 LHB antibody  >28 publications with hCG and LHB
 FSHB antibody  >27 publications with hCG and FSHB
 FSHR antibody  >6 publications with hCG and FSHR
 TSHB antibody  >5 publications with hCG and TSHB
 LHCGR antibody  >3 publications with hCG and LHCGR
 CGB8 antibody  >1 publications with hCG and CGB8
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
Diseases associated with anti-hCG antibodyOrgans/Tissues associated with anti-hCG antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >280 publications with hCG and Adenocarcinoma
 Nervous System Diseases Antibodies  >170 publications with hCG and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >137 publications with hCG and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >116 publications with hCG and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >108 publications with hCG and Cardiovascular Diseases
 Disease Progression Antibodies  >95 publications with hCG and Disease Progression
 Hyperplasia Antibodies  >77 publications with hCG and Hyperplasia
 Liver Diseases Antibodies  >68 publications with hCG and Liver Diseases
 Liver Neoplasms Antibodies  >68 publications with hCG and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >67 publications with hCG and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >168 publications with hCG and Brain
 Lung Antibodies  >165 publications with hCG and Lung
 Liver Antibodies  >138 publications with hCG and Liver
 Stomach Antibodies  >137 publications with hCG and Stomach
 Thyroid Antibodies  >105 publications with hCG and Thyroid
 Heart Antibodies  >102 publications with hCG and Heart
 Vascular Antibodies  >100 publications with hCG and Vascular
 Muscle Antibodies  >99 publications with hCG and Muscle
 Pituitary Gland Antibodies  >73 publications with hCG and Pituitary Gland
 Skin Antibodies  >58 publications with hCG and Skin
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