NP_084160.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
heparan-alpha-glucosaminide N-acetyltransferase
NCBI Official Synonym Full Names
heparan-alpha-glucosaminide N-acetyltransferase
NCBI Official Synonym Symbols
Tmem76; AW208455; D8Ertd354e; 9430010M12Rik [Similar Products]
NCBI Protein Information
heparan-alpha-glucosaminide N-acetyltransferase; transmembrane protein 76
UniProt Protein Name
Heparan-alpha-glucosaminide N-acetyltransferase
UniProt Synonym Protein Names
Transmembrane protein 76
UniProt Synonym Gene Names
UniProt Entry Name
HGNAT_MOUSE
UniProt Comments for Hgsnat
HGSNAT: Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. Defects in HGSNAT are the cause of mucopolysaccharidosis type 3C (MPS3C); also known as Sanfilippo C syndrome. MPS3C is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Acetyltransferase; Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - glycosaminoglycan degradation; EC 2.3.1.78
Cellular Component: membrane; lysosome; lysosomal membrane; integral to membrane
Molecular Function: transferase activity; heparan-alpha-glucosaminide N-acetyltransferase activity; transferase activity, transferring acyl groups
Biological Process: lysosomal transport; protein oligomerization
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Pathways associated with anti-Hgsnat antibody
Diseases associated with anti-Hgsnat antibody
Organs/Tissues associated with anti-Hgsnat antibody
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