AAH62595.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Histocompatibility (minor) 13
NCBI Official Synonym Full Names
histocompatibility (minor) 13
NCBI Official Synonym Symbols
H13; SPP; IMP1; PSL3; IMPAS; SPPL1; PSENL3; IMPAS-1; MSTP086; dJ324O17.1 [Similar Products]
NCBI Protein Information
minor histocompatibility antigen H13; IMP-1; hIMP1; intramembrane protease 1; presenilin-like protein 3; signal peptide peptidase beta; signal peptide peptidase like 1; minor histocompatibility antigen 13
UniProt Protein Name
Minor histocompatibility antigen H13
UniProt Synonym Protein Names
Intramembrane protease 1; IMP-1; IMPAS-1; hIMP1; Presenilin-like protein 3; Signal peptide peptidase
UniProt Synonym Gene Names
UniProt Entry Name
HM13_HUMAN
NCBI Summary for HM13
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HM13
HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 3.4.23.-; Endoplasmic reticulum; Protease
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: cell surface; membrane; rough endoplasmic reticulum; endoplasmic reticulum; plasma membrane
Molecular Function: peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; aspartic endopeptidase activity, intramembrane cleaving
Biological Process: membrane protein intracellular domain proteolysis; membrane protein proteolysis; membrane protein ectodomain proteolysis
Research Articles on HM13
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Diseases associated with anti-HM13 antibody
Organs/Tissues associated with anti-HM13 antibody
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